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    PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES
    1.
    发明申请
    PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES 失效
    吡咯并嘧啶和吡咯烷酮衍生物

    公开(公告)号：US20110137031A1

    公开(公告)日：2011-06-09

    申请号：US10584946

    申请日：2005-01-06

    申请人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E.J. Kennis

    发明人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E.J. Kennis

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine or pyrrolotriazine derivative substituted with a carbamoyl group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

    摘要翻译： 本发明的目的是提供一种抗CRF受体的拮抗剂，其作为治疗或预防药物是有效的，其涉及CRF被认为涉及的疾病，例如抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食 疾病，高血压，胃疾病，药物依赖，癫痫，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，特异性，肠易激综合征，睡眠障碍，皮肤病，精神分裂症，疼痛等。 由下式[I]表示的氨基甲酰基取代的吡咯并嘧啶或吡咯并三嗪衍生物：对CRF受体具有高亲和力，并且对于认为涉及CRF的疾病是有效的。

    THIENOPYRIMIDINE AND THIENOPYRIDINE DERIVATIVES SUBSTITUTED WITH CYCLIC AMINO GROUP
    3.
    发明申请
    THIENOPYRIMIDINE AND THIENOPYRIDINE DERIVATIVES SUBSTITUTED WITH CYCLIC AMINO GROUP 审中-公开
    用环状氨基取代的三烯酰基嘧啶和三烯吡啶衍生物

    公开(公告)号：US20090111835A1

    公开(公告)日：2009-04-30

    申请号：US12338698

    申请日：2008-12-18

    申请人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E.J. Kennis

    发明人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E.J. Kennis

    IPC分类号： A61K31/519 ,  C07D495/04 ,  A61K31/4365

    CPC分类号： C07D495/04

    摘要： An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, dermatitides, schizophrenia, pain, etc. A thienopyrimidine or thienopyridine derivative substituted with a cyclic amino group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

    摘要翻译： 本发明的目的是提供一种抗CRF受体的拮抗剂，其作为治疗或预防药物是有效的，其涉及CRF被认为涉及的疾病，例如抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食 疾病，高血压，胃疾病，药物依赖，癫痫，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，特异性，肠易激综合征，睡眠障碍，皮肤病，精神分裂症，疼痛等。 由下式[I]表示的环状氨基取代的噻吩并嘧啶或噻吩并吡啶衍生物对CRF受体具有高亲和力，对于认为涉及CRF的疾病有效。

    PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH A CYCLIC AMINO GROUP AS CRF ANTAGONISTS
    5.
    发明申请
    PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH A CYCLIC AMINO GROUP AS CRF ANTAGONISTS 审中-公开
    以循环氨基作为CRF拮抗剂取代吡咯并嘧啶衍生物和吡咯啉衍生物

    公开(公告)号：US20110124862A1

    公开(公告)日：2011-05-26

    申请号：US13018928

    申请日：2011-02-01

    申请人： Atsuro NAKAZATO ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E.J. Kennis

    发明人： Atsuro NAKAZATO ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E.J. Kennis

    IPC分类号： C07D487/04 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： [Problem to be Solved] An object of the present invention is to provide an antagonist against CRF receptors and/or an agonist for δ receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc.[Solution] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following formula [I] has a high affinity for CRF receptors and/or δ receptors, and is effective against diseases in which CRF is considered to be involved.

    摘要翻译： [待解决的问题]本发明的目的是提供一种拮抗CRF受体拮抗剂和/或对δ受体的激动剂，其作为用于涉及CRF的疾病的治疗或预防剂是有效的，例如 抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食障碍，高血压，胃肠道疾病，药物依赖，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，脱发，肠易激综合征， 睡眠障碍，癫痫，皮肤病，精神分裂症，疼痛等。[溶液]由下式[I]表示的环状氨基取代的吡咯并嘧啶或吡咯并吡啶衍生物对CRF受体和/或δ受体具有高亲和性， 对抗CRF被认为参与的疾病有效。

    Pyrrolopyrimidine and Pyrrolopyridine Derivatives Substituted with a Cyclic Amino Group As Crf Antagonists
    6.
    发明申请
    Pyrrolopyrimidine and Pyrrolopyridine Derivatives Substituted with a Cyclic Amino Group As Crf Antagonists 失效
    以环状氨基取代的吡咯并嘧啶和吡咯并吡啶衍生物作为Crf拮抗剂

    公开(公告)号：US20080280928A1

    公开(公告)日：2008-11-13

    申请号：US11630042

    申请日：2005-06-24

    申请人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E.J. Kennis

    发明人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E.J. Kennis

    IPC分类号： A61K31/437 ,  C07D471/04 ,  A61K31/519 ,  A61P25/00 ,  C07D487/04

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： [PROBLEM TO BE SOLVED] An object of the present invention is to provide an antagonist against CRF receptors and/or an agonist for δ receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. [SOLUTION] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following a [I] has a high affinity for CRF receptors and/or δ receptors, and is effective against diseases in which CRF is considered to be involved.

    摘要翻译： [待解决的问题]本发明的目的是提供一种拮抗CRF受体拮抗剂和/或δ受体激动剂，其作为治疗或预防药物是有效的，其涉及CRF被认为是涉及的疾病，例如 抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食障碍，高血压，胃肠道疾病，药物依赖，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，脱发，肠易激综合征， 睡眠障碍，癫痫，皮肤病，精神分裂症，疼痛等。解决方案由以下[I]表示的环状氨基取代的吡咯并嘧啶或吡咯并吡啶衍生物对CRF受体和/或δ受体具有高亲和力，并且是 对抗CRF被认为参与的疾病有效。

    Thienopyrimidine and Thienopyridine Derivatives Substituted with Cyclic Amino Group
    7.
    发明申请
    Thienopyrimidine and Thienopyridine Derivatives Substituted with Cyclic Amino Group 失效
    用环氨基取代的噻吩并嘧啶和噻吩并吡啶衍生物

    公开(公告)号：US20070254898A1

    公开(公告)日：2007-11-01

    申请号：US10584951

    申请日：2005-01-06

    申请人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo Kennis

    发明人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo Kennis

    IPC分类号： A61K31/519 ,  A61K31/435 ,  C07D471/02 ,  C07D487/00

    CPC分类号： C07D495/04

    摘要： [Problem to be Solved] An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. [Solution] A thienopyrimidine or thienopyridine derivative substituted with a cyclic amino group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

    摘要翻译： [待解决的问题]本发明的目的是提供一种抗CRF受体的拮抗剂，其作为治疗或预防药物有效，其中CRF被认为是涉及的疾病，例如抑郁症，焦虑症，阿尔茨海默病，帕金森病 疾病，亨廷顿氏舞蹈病，饮食失调，高血压，胃疾病，药物依赖，癫痫，脑梗死，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，特发性，肠易激综合征，睡眠障碍，癫痫，皮肤病 ，精神分裂症等。[溶液]由下式[I]表示的环状氨基取代的噻吩并嘧啶或噻吩并吡啶衍生物对CRF受体具有高亲和力，对于CRF被认为是涉及的疾病有效。

    Pyrrolopyrimidine and pyrrolotriazine derivatives
    9.
    发明授权
    Pyrrolopyrimidine and pyrrolotriazine derivatives 失效
    吡咯并嘧啶和吡咯并三嗪衍生物

    公开(公告)号：US08106194B2

    公开(公告)日：2012-01-31

    申请号：US10584946

    申请日：2005-01-06

    申请人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E. J. Kennis

    发明人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E. J. Kennis

    IPC分类号： C07D251/02 ,  C07D251/42 ,  C07D239/70

    CPC分类号： C07D487/04

    摘要： An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine or pyrrolotriazine derivative substituted with a carbamoyl group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

    摘要翻译： 本发明的目的是提供一种抗CRF受体的拮抗剂，其作为治疗或预防药物是有效的，其涉及CRF被认为涉及的疾病，例如抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食 疾病，高血压，胃疾病，药物依赖，癫痫，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，特异性，肠易激综合征，睡眠障碍，皮肤病，精神分裂症，疼痛等。 由下式[I]表示的氨基甲酰基取代的吡咯并嘧啶或吡咯并三嗪衍生物：对CRF受体具有高亲和力，并且对于认为涉及CRF的疾病是有效的。

    Pyrrolo[2,3-D]pyrimidine derivatives substituted with a cyclic amino group
    10.
    发明授权
    Pyrrolo[2,3-D]pyrimidine derivatives substituted with a cyclic amino group 失效
    被环状氨基取代的吡咯并[2,3-D]嘧啶衍生物

    公开(公告)号：US07951811B2

    公开(公告)日：2011-05-31

    申请号：US11630042

    申请日：2005-06-24

    申请人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E. J. Kennis

    发明人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E. J. Kennis

    IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/24 ,  A61P25/28 ,  A61P25/16 ,  A61P29/00

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： [PROBLEM TO BE SOLVED]An object of the present invention is to provide an antagonist against CRF receptors and/or an agonist for δ receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc.[SOLUTION]A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following a [I] has a high affinity for CRF receptors and/or δ receptors, and is effective against diseases in which CRF is considered to be involved.

    摘要翻译： [待解决的问题]本发明的目的是提供一种抗CRF受体拮抗剂和/或对δ受体的激动剂，其有效作为涉及CRF的疾病的治疗或预防剂，例如 抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食障碍，高血压，胃肠道疾病，药物依赖，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，脱发，肠易激综合征， 睡眠障碍，癫痫，皮肤病，精神分裂症，疼痛等。解决方案：由以下[I]表示的环状氨基取代的吡咯并嘧啶或吡咯并吡啶衍生物对CRF受体和/或δ受体具有高亲和性，并且是 对抗CRF被认为参与的疾病有效。