公开(公告)号：US20090130191A1

公开(公告)日：2009-05-21

申请号：US12084151

申请日：2006-10-27

申请人： Atsushi Ishikado ,  Hiromichi Imanaka ,  Hirohisa Suido ,  Taketoshi Makino

发明人： Atsushi Ishikado ,  Hiromichi Imanaka ,  Hirohisa Suido ,  Taketoshi Makino

IPC分类号： A61K9/127 ,  C07K14/79 ,  A61K38/40 ,  A61P19/10

CPC分类号： A61K9/127 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/1623 ,  A61K9/2077 ,  A61K38/40

摘要： A growth of osteoclasts is inhibited by orally administering a liposomal lactoferrin. Thus a bone disease in which the osteoclast is involved is effectively prevented or treated by orally administering the liposomal lactoferrin. The present invention provides an osteoclast growth inhibitor, an oral composition and a preventive and therapeutic agent for bone diseases (osteoporosis, rheumatoid, periodontal diseases with alveolar bone resorption, which contain the liposomal lactoferrin, and a preventive or therapeutic method for the bone diseases. According to the present invention, the growth of the osteoclasts can be inhibited and the bone diseases due to promotion of the osteoclast growth can be prevented or treated.

摘要翻译： 通过口服施用脂质体乳铁蛋白抑制破骨细胞的生长。 因此，通过口服施用脂质体乳铁蛋白有效地防止或治疗破骨细胞所涉及的骨病。 本发明提供破骨细胞生长抑制剂，口腔用组合物，骨病（骨质疏松症，类风湿病，牙槽骨吸收的牙周病，含有脂质体乳铁蛋白）以及骨疾病的预防或治疗方法的预防和治疗剂。 根据本发明，可以抑制破骨细胞的生长，并且可以防止或治疗由于促进破骨细胞生长引起的骨疾病。

公开(公告)号：US06669932B2

公开(公告)日：2003-12-30

申请号：US09445562

申请日：2000-03-14

申请人： Hiromichi Imanaka ,  Hideya Ando ,  Taketoshi Makino

发明人： Hiromichi Imanaka ,  Hideya Ando ,  Taketoshi Makino

IPC分类号： A61K9127

CPC分类号： A61K8/361 ,  A61K8/0212 ,  A61K8/14 ,  A61K8/37 ,  A61K8/375 ,  A61K8/553 ,  A61K8/64 ,  A61K8/65 ,  A61K8/67 ,  A61K8/676 ,  A61K8/678 ,  A61K8/735 ,  A61Q19/02 ,  A61Q19/10

摘要： A skin-whitening cosmetic material which contains an unsaturated fatty acid or a derivative thereof as the active ingredient, is highly effective in making the color of pigmentation on the skin lighter at a lower concentration, and is highly safe. The skin-whitening cosmetic material comprises (A) at least one member selected from unsaturated fatty acids having from 18 to 22 carbon atoms and having from 2 to 6 double bonds in the molecular structure, and derivatives thereof, (B) a phospholipid, (C) an antioxidant, (D) at least one member selected from proteins and hydrolyzates thereof, and (E) at least one member selected from muco-polysaccharides and salts thereof.

摘要翻译： 含有不饱和脂肪酸或其衍生物作为活性成分的皮肤美白化妆品，能够以更低的浓度使皮肤上色素沉着的颜色变得更亮，并且是高度安全的。 皮肤美白化妆品包含（A）选自具有18-22个碳原子的不饱和脂肪酸和分子结构中具有2至6个双键的至少一种，及其衍生物，（B）磷脂， C）抗氧化剂，（D）选自蛋白质及其水解产物中的至少一种，和（E）选自粘多糖及其盐中的至少一种。

公开(公告)号：US20080102111A1

公开(公告)日：2008-05-01

申请号：US11885756

申请日：2006-03-09

申请人： Hiromichi Imanaka

发明人： Hiromichi Imanaka

IPC分类号： A61K9/127 ,  A61K31/56

CPC分类号： A61K31/575 ,  A23L33/11 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/127 ,  A61K9/1272 ,  A23V2200/308 ,  A23V2250/612 ,  A23V2250/2136 ,  A23V2250/5118 ,  A23V2250/5086 ,  A23V2250/04

摘要： A novel use is disclosed of liposomes that contain phytosterol (e.g., β-sitosterol, campesterol, stigmasterol, brassicasterol, ergosterol, and ergostadienol, and so forth). It has been newly discovered that liposomes that contain phytosterol have a cancer metastasis inhibiting activity. Cancer metastasis is inhibited by the oral administration of liposomes that contain phytosterol and these liposomes are therefore useful for the prevention and treatment of cancer.

摘要翻译： 公开了含有植物甾醇（例如β-谷甾醇，菜油甾醇，豆甾醇，菜子甾醇，麦角甾醇，麦角甾醇，等等）的脂质体的新用途。 新发现含有植物甾醇的脂质体具有癌转移抑制活性。 通过口服含有植物甾醇的脂质体抑制癌转移，因此这些脂质体可用于预防和治疗癌症。