公开(公告)号：US5471230A

公开(公告)日：1995-11-28

申请号：US655153

申请日：1991-02-13

申请人： Atsushi Saito ,  Akiro Okubo ,  Fumihiko Watanabe ,  Yasuyuki Shinada

发明人： Atsushi Saito ,  Akiro Okubo ,  Fumihiko Watanabe ,  Yasuyuki Shinada

IPC分类号： B41J2/165

CPC分类号： B41J2/16511 ,  B41J2/16523 ,  B41J2/16585

摘要： A capping device to be used with an ink jet recording apparatus for recording on a recording medium by discharging ink onto the recording medium comprises a capping member for covering a discharge port of an ink jet recording head for discharging ink to effect the recording on the recording medium and a pushing member provided on the capping member at an inner side thereof for pushing with pressure against the discharge port of the ink jet recording head. An ink jet recording apparatus is disclosed using the capping device.

摘要翻译： 与喷墨记录装置一起使用的用于在记录介质上通过将油墨喷射到记录介质上而进行记录的封盖装置包括用于覆盖用于排出墨水的喷墨记录头的排出口的封盖构件，以在记录上进行记录 介质和推动构件，其设置在封盖构件的内侧，用于将压力压靠在喷墨记录头的排出口。 公开了使用封盖装置的喷墨记录装置。

公开(公告)号：US5166707A

公开(公告)日：1992-11-24

申请号：US655317

申请日：1991-02-13

申请人： Fumihiko Watanabe ,  Atsushi Saito ,  Akio Okubo ,  Yasuyuki Shinada

发明人： Fumihiko Watanabe ,  Atsushi Saito ,  Akio Okubo ,  Yasuyuki Shinada

IPC分类号： B41J2/165

CPC分类号： B41J2/16585 ,  B41J2/16523

摘要： An ink jet recording apparatus which records on a recording medium by discharging ink on a recording medium. The ink jet recording apparatus comprises an ink jet recording head which discharges ink to record on a recording medium, a conveyance route which leads the recording medium in the exhaust direction passing above the recording head, and a cap which covers the discharge ports of the recording head provided below the ink jet recording head.

公开(公告)号：US5481290A

公开(公告)日：1996-01-02

申请号：US96841

申请日：1993-07-26

申请人： Fumihiko Watanabe ,  Akio Okubo ,  Atsushi Saito ,  Yasuyuki Shinada

发明人： Fumihiko Watanabe ,  Akio Okubo ,  Atsushi Saito ,  Yasuyuki Shinada

IPC分类号： B41J2/165 ,  B41J11/04 ,  B41J2/01 ,  B41J11/20

CPC分类号： B41J2/16511 ,  B41J11/04 ,  B41J2/16523 ,  B41J2/16585

摘要： A recording apparatus which records on a recording medium. The recording apparatus includes a recording head which prints on a recording medium, a body of revolution which is rotatably mounted, and a platen roller capable of being displaced in the recording head direction and in the body of revolution peripheral direction. The platen roller is positioned against the recording head.

摘要翻译： 记录在记录介质上的记录装置。 该记录装置包括一记录头，该记录头在记录介质上打印，一转动体可旋转地安装，一个能够在记录头方向和旋转体周向移位的压纸辊。 压纸辊抵靠记录头定位。

公开(公告)号：US5481283A

公开(公告)日：1996-01-02

申请号：US409963

申请日：1995-03-24

申请人： Fumihiko Watanabe ,  Akio Okubo ,  Atsushi Saito ,  Yasuyuki Shinada

发明人： Fumihiko Watanabe ,  Akio Okubo ,  Atsushi Saito ,  Yasuyuki Shinada

IPC分类号： B41J2/165

CPC分类号： B41J2/16511 ,  B41J2/16523 ,  B41J2/16585

摘要： A recovery system comprises a cap means for covering the discharging ports of a recording head to perform recording by discharging ink, and a wiper assembly for wiping the discharging port face of the recording head, the wiper assembly being a large-sized wiping member and a small-sized wiping member, wherein the small-sized wiping member is first in contact with the discharging port face of the recording head. A guide member guides the recording head and the cap at the time of mating and a holder holds the recording head and cap, which holder holds the recording head and said cap in such a manner that they can relatively be displaced in the direction crossing the contacting direction thereof. A cap unit with the cap and wiper assembly can be rotated within a rotational area of the recording head. Wiping by the wiper assembly is performed in such a manner that following the rotation of the recording head, the small-sized wiping member is first in contact therewith and subsequently, the large-sized wiping member is in contact therewith.

摘要翻译： 回收系统包括用于覆盖记录头的排出口以通过排出墨水进行记录的盖装置和用于擦拭记录头的排出口面的擦拭器组件，刮水器组件是大尺寸的擦拭构件和 小型擦拭构件，其中小尺寸擦拭构件首先与记录头的排出口面接触。 引导构件在配合时引导记录头和盖，并且保持器保持记录头和盖，该保持器以这样的方式保持记录头和盖，使得它们可以在与接触的方向相对移位 方向。 具有盖和刮水器组件的盖单元可以在记录头的旋转区域内旋转。 通过擦拭器组件的擦拭以这样一种方式进行：在记录头的旋转之后，小尺寸的擦拭部件首先与其接触，随后大尺寸的擦拭部件与其接触。

公开(公告)号：US5988787A

公开(公告)日：1999-11-23

申请号：US478828

申请日：1995-06-07

申请人： Fumihiko Watanabe ,  Takeshi Ono ,  Akio Okubo ,  Atsushi Saito ,  Yasuhiko Ikeda

发明人： Fumihiko Watanabe ,  Takeshi Ono ,  Akio Okubo ,  Atsushi Saito ,  Yasuhiko Ikeda

IPC分类号： B41J2/01 ,  B41J2/165 ,  B41J2/18 ,  B41J2/185 ,  B41J29/00 ,  B41J2/14 ,  B41J2/175

CPC分类号： B41J2/16585

摘要： A recording unit cartridge includes as a unit: a recording head for ejecting ink to effect recording; an ink supply system for supplying the ink to the recording head; a capping member for covering an ink ejection side surface of the recording head; an ink collecting member for the ink discharged to recover the recording head and not used for recording; a cleaning member for cleaning the ink ejection side surface of the recording head; and a casing for containing as a unit the head system and members, wherein the unit cartridge is detachably mountable to a main assembly of a recording apparatus.

摘要翻译： 记录单元盒包括：用于喷射墨水以进行记录的记录头; 用于将油墨供应到记录头的供墨系统; 用于覆盖记录头的喷墨侧表面的封盖构件; 用于排出的墨回收记录头而不用于记录的墨水收集构件; 用于清洁记录头的喷墨侧表面的清洁构件; 以及用于将头系统和构件作为单元容纳的壳体，其中所述单元盒可拆卸地安装到记录装置的主组件。

公开(公告)号：US5548309A

公开(公告)日：1996-08-20

申请号：US737657

申请日：1991-07-30

申请人： Akio Okubo ,  Atsushi Saito ,  Fumihiko Watanabe

发明人： Akio Okubo ,  Atsushi Saito ,  Fumihiko Watanabe

IPC分类号： B41J2/165

CPC分类号： B41J2/16508 ,  B41J2/16588

摘要： A wiping apparatus for a recording head of an ink jet recording apparatus, which has a recording head including an ink ejection portion, includes a wiping member, and a rotation device for rotating the recording head and/or the wiping member so that the wiping member slides on the ink ejection portion. The apparatus prevents the splash of ink caused when the wiping member leaves the ink ejection portion by using one of the following techniques: First, a wiping speed is decreased at the end of wiping; second, an angle between the wiping member and the ink ejection portion is declined as the wiping proceeds; third, the first and second techniques are combined; and fourth, an approach amount of the wiping member to the ink ejection portion is reduced at least just before the wiping member leaves the ink ejection portion. Using one of these technique enables the wiping member to leave softly the ink ejection portion by weakening the restoring force of the wiping member, thereby preventing ink from splashing into the surroundings during the wiping operation.

摘要翻译： 一种用于喷墨记录装置的记录头的擦拭装置，具有包括喷墨部分的记录头，包括擦拭部件和用于使记录头和/或擦拭部件旋转的旋转装置，使得擦拭部件 在喷墨部分上滑动。 该装置通过使用以下技术之一防止擦拭构件离开墨水喷射部时引起的墨水飞溅：首先，在擦拭结束时擦拭速度降低; 第二，随着擦拭的进行，擦拭部件和喷墨部分之间的角度下降; 第三，第一和第二技术相结合; 第四，至少恰好在擦拭构件离开墨水喷射部分之前，将擦拭构件到墨水喷射部分的接近量减少。 使用这些技术之一，通过削弱擦拭构件的恢复力，擦拭构件能够轻轻地离开墨水喷射部分，从而防止在擦拭操作期间墨水溅入周围环境。

公开(公告)号：US07825146B2

公开(公告)日：2010-11-02

申请号：US10565948

申请日：2004-07-28

申请人： Fumihiko Watanabe ,  Naoki Yoshikawa ,  Yoshinori Tamura

发明人： Fumihiko Watanabe ,  Naoki Yoshikawa ,  Yoshinori Tamura

IPC分类号： A61K31/422

CPC分类号： C07D261/08 ,  A61K31/42

摘要： A compound represented by the general formula (I-A): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally substituted arylene and the like; R5 is a group represented by the formula: R6 is optionally substituted aryl and the like, its optically active substance, their pharmaceutically acceptable salt, or a solvate thereof; and a metalloproteinase inhibitor containing them.

摘要翻译： 由通式（I-A）表示的化合物：其中R1是羟基等; R2是任选取代的低级烷基等; R3是氢原子等; R4是任选取代的亚芳基等; R5是由下式表示的基团：R6是任选取代的芳基等，其光学活性物质，其药学上可接受的盐或其溶剂化物; 和含有它们的金属蛋白酶抑制剂。

公开(公告)号：US20090069304A1

公开(公告)日：2009-03-12

申请号：US12281216

申请日：2007-03-01

申请人： Mikayo Hayashi ,  Fumihiko Watanabe

发明人： Mikayo Hayashi ,  Fumihiko Watanabe

IPC分类号： A61K31/5513 ,  C07D243/08 ,  C07D241/04 ,  A61K31/4965

CPC分类号： C07D209/86 ,  C07D211/96 ,  C07D241/04 ,  C07D243/08 ,  C07D295/22

摘要： Since it is thought that if the activity of MMP-13 can be inhibited, this will largely contribute to improvement or prevention of progession of pathological states, particularly, osteoarthritis (OA), resulting from or associated with the MMP-13 activity, the development of MMP-13 inhibitors is anticipated. There are provided a compound represented by the general formula (I): wherein R1 is optionally substituted aryl etc.; Z is C1-C5 alkylene which may be substituted and may be interrupted with a substituent selected from Substituent group a etc.; A is the formula: (R6 and R7 are each independently halogen, lower alkyl etc.; m and n are each independently 0, 1, or 2); R2 is a hydrogen atom, optionally substituted lower alkyl etc.; R3 is a hydrogen atom, optionally substituted lower alkyl etc.; R4 is a hydrogen atom; or R3 and R4 may be taken together with an adjacent carbon atom to from a ring; R5 is hydroxy, lower alkyloxy etc.), or an optically active isomer, a pharmaceutically acceptable salt or a solvate thereof, and a pharmaceutical composition containing it as an active ingredient, which has the MMP-13 inhibiting activity.

摘要翻译： 由于认为如果可以抑制MMP-13的活性，这将大大有助于改善或预防由MMP-13活性引起或与MMP-13活性相关的病理状态，特别是骨关节炎（OA），发展 的MMP-13抑制剂。 提供由通式（I）表示的化合物：其中R 1是任选取代的芳基等; Z是可以被取代的C1-C5亚烷基，可以被选自取代基组a等的取代基中断; A是下式：（R 6和R 7各自独立地为卤素，低级烷基等; m和n各自独立地为0,1或2）; R2是氢原子，任选取代的低级烷基等; R3是氢原子，任选取代的低级烷基等; R4是氢原子; 或者R 3和R 4可以与相邻的碳原子一起与环一起取代; R5是羟基，低级烷氧基等）或光学活性异构体，其药学上可接受的盐或溶剂合物，以及含有其作为活性成分的具有MMP-13抑制活性的药物组合物。

公开(公告)号：US5206666A

公开(公告)日：1993-04-27

申请号：US617365

申请日：1990-11-23

申请人： Fumihiko Watanabe ,  Takeshi Ono

发明人： Fumihiko Watanabe ,  Takeshi Ono

IPC分类号： B41J2/165 ,  B41J13/00 ,  B41J13/14 ,  B41J25/316

CPC分类号： B41J2/16588 ,  B41J13/14 ,  B41J2/16585 ,  B41J25/316 ,  B41J2202/21

摘要： An ink jet recording apparatus includes a full-line type recording head having plural ejection outlets; a shaft for rotatably supporting the recording head between a recording position in which the ink is ejected in a non-vertical direction and a non-recording position in which the ink is ejected substantially vertically; a device, disposed adjacent a recording position of the recording head, contributable to feeding of the recording material; and a positioning plate press-contacted to the contributable device to confine a recording surface of the recording material in cooperation with the contributable device.

公开(公告)号：US5008409A

公开(公告)日：1991-04-16

申请号：US447513

申请日：1989-12-07

申请人： Masayuki Narisada ,  Mitsuaki Ohtani ,  Fumihiko Watanabe ,  Kyozo Kawata

发明人： Masayuki Narisada ,  Mitsuaki Ohtani ,  Fumihiko Watanabe ,  Kyozo Kawata

IPC分类号： C07C303/40 ,  C07C311/20

CPC分类号： C07C303/40

摘要： A process for preparing a compound of Formula (I): ##STR1## wherein R is phenyl or phenyl substituted with hydroxy, lower alkoxy, halogen or lower alkyl; Y is unsubstituted or substituted methylene, ethylene, vinylene or oxygen; m is 0 or 1; n is 0, 1 or 2; and q is 1, 2, 3 or 4; with the limitation that when m is 0, n is not 0, and when m is 1, n is not 2, which process comprises:(a) reacting an aldehyde of Formula (II); ##STR2## wherein R, Y, m and n are as defined above, under reaction conditions for the Wittig Reaction with a ylide of Formula (III):(R.sup.1).sub.3 P.dbd.CH(CH.sub.2).sub.q COOM (III) wherein R.sup.1 is C.sub.1 -C.sub.8 alkyl or aryl, M is an alkali metal and q is as defined above;(b) treating the reaction mixture of step (a) with an alkaline earth metal halide under alkaline conditions to form the alkaline earth metal salt of the carboxylic acid of Formula (I);(c) extracting the alkaline earth metal salt of the carboxylic acid of Formula (I) in an organic solvent; and(d) recovering the free carboxylic acid of Formula (I) from the organic solvent.