公开(公告)号：US06518284B2

公开(公告)日：2003-02-11

申请号：US09824189

申请日：2001-04-02

申请人： Aurello Orjales Venero ,  Antonio Toledo Avello ,  Carmen Pumar Duran

发明人： Aurello Orjales Venero ,  Antonio Toledo Avello ,  Carmen Pumar Duran

IPC分类号： A61K314465

CPC分类号： C07D211/22

摘要： New 4-substituted piperidines of the following general formula (I) are disclosed in which R1 and R2 are substituted in unsubstituted aryl radicals, which compounds are obtained as racemic mixtures and as pure enantiomers. The compounds, and their pharmaceutically acceptable salts, inhibit the serotonin and/or noradrenaline reuptake, and are useful as medicaments in disorders in which an increase of levels of those neurotransmitters is necessary.

摘要翻译： 公开了以下通式（I）的新的4-取代的哌啶，其中R 1和R 2在未取代的芳基中被取代，该化合物作为外消旋混合物和纯对映体获得。化合物及其药学上可接受的盐抑制 5-羟色胺和/或去甲肾上腺素再摄取，并且可用作需要增加这些神经递质水平的疾病中的药物。

公开(公告)号：US20070265306A1

公开(公告)日：2007-11-15

申请号：US11486350

申请日：2006-07-13

申请人： Aurelio Orjales Venero ,  Ramon Mosquera Pestana ,  Maria Carmen Pumar Duran ,  Antonio Toledo Avello ,  Gonzalo Canal Mori ,  Maravillas Bordell Martin

发明人： Aurelio Orjales Venero ,  Ramon Mosquera Pestana ,  Maria Carmen Pumar Duran ,  Antonio Toledo Avello ,  Gonzalo Canal Mori ,  Maravillas Bordell Martin

IPC分类号： A61K31/445 ,  C07D211/20

CPC分类号： C07D211/22

摘要： The present patent application is directed to 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulfonic acid salt (formula I), its synthesis and a method for treating and/or preventing a serotonine and/or norepinephrine mediated disease or condition. The present invention is also directed to pharmaceutical compositions comprising the same.

摘要翻译： 本专利申请涉及4 - [（3-氟苯氧基）苯基甲基]哌啶甲磺酸盐（式I），其合成和治疗和/或预防5-羟色胺和/或去甲肾上腺素介导的疾病或病症的方法。 本发明还涉及包含其的药物组合物。

公开(公告)号：US20100004283A1

公开(公告)日：2010-01-07

申请号：US12299907

申请日：2007-04-12

申请人： Aurelio Orjales Venero ,  Ramon Mosquera Pestana ,  Maria Carmen Pumar Duran ,  Antonio Toledo Avello ,  Gonzalo Canal Mori ,  Maravillas Bordell Martin

发明人： Aurelio Orjales Venero ,  Ramon Mosquera Pestana ,  Maria Carmen Pumar Duran ,  Antonio Toledo Avello ,  Gonzalo Canal Mori ,  Maravillas Bordell Martin

IPC分类号： A61K31/445 ,  C07D211/18 ,  A61P25/24

CPC分类号： C07D211/22

摘要： The present patent application is directed to 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulfonic acid salt (formula I), its synthesis and use in the manufacture of a medicament for the treatment and/or prevention of a serotonine and/or norepinephrine mediated disease or condition. The present invention is also directed to pharmaceutical compositions comprising the same.

摘要翻译： 本专利申请涉及4 - [（3-氟苯氧基）苯甲基]哌啶甲磺酸盐（式I），其合成和用于制备用于治疗和/或预防5-羟色胺和/或去甲肾上腺素的药物 介导的疾病或病症。 本发明还涉及包含其的药物组合物。