公开(公告)号：US20220213447A1

公开(公告)日：2022-07-07

申请号：US17613427

申请日：2020-05-22

Applicant: Avitide LLC

Inventor： William Scott Dodson ,  Brandon Kier ,  Brandon Coyle ,  Sarah Valentini ,  Thomas Scanlon ,  Warren Kett

IPC: C12N7/00 ,  C07K7/02 ,  C07K7/06 ,  C07K7/08 ,  B01D15/32 ,  B01D15/38

Abstract: Provided herein are affinity agents comprising ligands that specifically bind adeno-associated virus. The affinity agents are useful for binding, isolation, and/or purification of adeno-associated virus. Further disclosed are amino acid sequences of binding motifs or polypeptides comprised by the ligands, and associated modifications of the binding motifs and/or polypeptides, as well as a method of making the affinity agents.

公开(公告)号：US20240026344A1

公开(公告)日：2024-01-25

申请号：US18031808

申请日：2021-10-13

Applicant: Avitide LLC

Inventor： Brandon Kier ,  Molly North ,  Sarmistha Bhattacharya ,  Thomas Scanlon ,  Warren Kett

IPC: C12N15/10

CPC classification number: C12N15/1037

Abstract: The present disclosure relates to the field of affinity chromatography, and more specifically to the provision of nucleic acid and polypeptide libraries encoding three-helix bundle protein domains suitable for selecting affinity ligands that specifically binds to a target molecule of interest. The disclosure also relates to methods of using those libraries to identify and isolate such affinity ligands to a target molecule.