公开(公告)号：US20070031335A1

公开(公告)日：2007-02-08

申请号：US10121024

申请日：2002-04-10

申请人： Aya Jakobovits ,  Pia Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene Hubert ,  Karen Jane Morrison ,  Robert Morrison ,  Arthur Raitano ,  Daniel Afar

发明人： Aya Jakobovits ,  Pia Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene Hubert ,  Karen Jane Morrison ,  Robert Morrison ,  Arthur Raitano ,  Daniel Afar

IPC分类号： A61K49/00 ,  A61K39/395 ,  C07K16/46 ,  C12N5/06

CPC分类号： C07K14/47 ,  A61K47/646 ,  A61K47/6851 ,  A61K47/6901 ,  A61K51/1045

摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.

摘要翻译： 图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此， 基因 2提供癌症的诊断，预后，预防和/或治疗靶点。 图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。

公开(公告)号：US20070041968A1

公开(公告)日：2007-02-22

申请号：US11156231

申请日：2005-06-17

申请人： Aya Jakobovits ,  Pia Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene Hubert ,  Karen Morrison ,  Robert Morrison ,  Arthur Raitano ,  Daniel Afar

发明人： Aya Jakobovits ,  Pia Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene Hubert ,  Karen Morrison ,  Robert Morrison ,  Arthur Raitano ,  Daniel Afar

IPC分类号： A61K48/00 ,  A61K39/395 ,  C12N15/861

CPC分类号： C07K14/47 ,  A61K47/646 ,  A61K47/6851 ,  A61K47/6901 ,  A61K51/1045

摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.

摘要翻译： 图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此， 基因 2提供癌症的诊断，预后，预防和/或治疗靶点。 图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。

公开(公告)号：US20070048299A1

公开(公告)日：2007-03-01

申请号：US11155906

申请日：2005-06-17

申请人： Aya Jakobovits ,  Pia Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene Hubert ,  Karen Morrison ,  Robert Morrison ,  Arthur Raitano ,  Daniel Afar

发明人： Aya Jakobovits ,  Pia Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene Hubert ,  Karen Morrison ,  Robert Morrison ,  Arthur Raitano ,  Daniel Afar

IPC分类号： A61K39/395 ,  A61K48/00 ,  C12N15/861

CPC分类号： C07K14/47 ,  A61K47/646 ,  A61K47/6851 ,  A61K47/6901 ,  A61K51/1045

摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.

公开(公告)号：US20070048283A1

公开(公告)日：2007-03-01

申请号：US11154298

申请日：2005-06-15

申请人： Aya Jakobovits ,  Pia Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene Hubert ,  Karen Morrison ,  Robert Morrison ,  Arthur Raitano ,  Daniel Afar

发明人： Aya Jakobovits ,  Pia Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene Hubert ,  Karen Morrison ,  Robert Morrison ,  Arthur Raitano ,  Daniel Afar

IPC分类号： A61K39/395 ,  A61K48/00

CPC分类号： C07K14/47 ,  A61K47/646 ,  A61K47/6851 ,  A61K47/6901 ,  A61K51/1045

摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.

公开(公告)号：US20050214211A1

公开(公告)日：2005-09-29

申请号：US11073349

申请日：2005-03-03

申请人： Pia Challita-Eid ,  Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Steven Mitchell ,  Daniel Afar ,  Douglas Saffran ,  Karen Morrison ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

发明人： Pia Challita-Eid ,  Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Steven Mitchell ,  Daniel Afar ,  Douglas Saffran ,  Karen Morrison ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

IPC分类号： A01K67/027 ,  A61K39/395 ,  A61K51/00 ,  C07K14/47 ,  C07K16/40 ,  C12N5/06

CPC分类号： C07K14/47

摘要： A novel gene (designated 121P2A3) and its encoded protein, and variants thereof, are described wherein 121P2A3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 121P2A3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 121P2A3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 121P2A3 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因（命名为121P2A3）及其编码的蛋白质及其变体，其中121P2A3在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，121P2A3提供诊断，预后， 癌症的预防和/或治疗靶标。 121P2A3基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与121P2A3反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US20070036762A1

公开(公告)日：2007-02-15

申请号：US11489907

申请日：2006-07-19

申请人： Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Daniel Afar ,  Wangmao Ge ,  Pia Challita-Eid ,  Aya Jakobovits

发明人： Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Daniel Afar ,  Wangmao Ge ,  Pia Challita-Eid ,  Aya Jakobovits

IPC分类号： A61K48/00 ,  C07H21/04 ,  C12N15/86

CPC分类号： C07K14/47

摘要： A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic and/or therapeutic target for cancers. The 85P1B3 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.

摘要翻译： 描述了一种新型基因（命名为85P1B3）及其编码的蛋白质。 虽然85P1B3在正常成人组织中表现出组织特异性表达，但是在多种癌症中异常表达，如表1所示。因此，85P1B3为癌症提供了诊断和/或治疗靶点。 85P1B3基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。

公开(公告)号：US20070054284A1

公开(公告)日：2007-03-08

申请号：US11368284

申请日：2006-03-02

申请人： Pia Challita-Eid ,  Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Karen Morrison ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

发明人： Pia Challita-Eid ,  Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Karen Morrison ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

IPC分类号： A61K48/00 ,  C12Q1/68 ,  C12N15/86 ,  C07K14/82

CPC分类号： C07K14/47 ,  A61K38/00 ,  C12N9/78 ,  Y10T436/25

摘要： A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 184P1E2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 184P1E2 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因（称为184P1E2）及其编码的蛋白及其变体，其中184P1E2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，184P1E2提供诊断，预后， 癌症的预防和/或治疗靶标。 184P1E2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与184P1E2反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US20070212299A1

公开(公告)日：2007-09-13

申请号：US11655822

申请日：2007-01-19

申请人： Aya Jakobovits ,  Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Wangmao Ge ,  Karen Morrison ,  Robert Morrison ,  Pia Challita-Eid

发明人： Aya Jakobovits ,  Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Wangmao Ge ,  Karen Morrison ,  Robert Morrison ,  Pia Challita-Eid

IPC分类号： A61K51/00 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C07K14/82 ,  C07K16/30 ,  C07K16/46

CPC分类号： C07K16/30 ,  A61K31/7088 ,  A61K39/00 ,  A61K51/1045 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3061 ,  C07K16/3069 ,  C07K16/40 ,  C07K2317/20 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2319/30 ,  C12N9/16 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57492 ,  Y02A50/466

摘要： A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.

摘要翻译： 描述了新颖的基因0161P2F10B（也称为161P2F10B）及其编码的蛋白质及其变体，其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，161P2F10B提供了诊断， 癌症的预后，预防和/或治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US20070037745A1

公开(公告)日：2007-02-15

申请号：US11090545

申请日：2005-03-25

申请人： Pia Challita-Eid ,  Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

发明人： Pia Challita-Eid ,  Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

IPC分类号： A01K67/00 ,  A61K39/395 ,  C12N5/06 ,  C07K14/82 ,  C07K16/18

CPC分类号： C07K14/82 ,  A01K2217/05 ,  A01K2267/0331

摘要： A novel gene (designated 213P1F11) and its encoded protein, and variants thereof, are described wherein 213P1F11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 213P1F11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 213P1F11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 213P1F11 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因（称为213P1F11）及其编码的蛋白及其变体，其中213P1F11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，213P1F11提供诊断，预后， 癌症的预防和/或治疗靶标。 213P1F11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与213P1F11反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US20070015704A1

公开(公告)日：2007-01-18

申请号：US11483302

申请日：2006-07-06

申请人： Arthur Raitano ,  Pia Challita-Eid ,  Mary Faris ,  Rene Hubert ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

发明人： Arthur Raitano ,  Pia Challita-Eid ,  Mary Faris ,  Rene Hubert ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

IPC分类号： A61K38/17

CPC分类号： C07K16/30 ,  A61K39/395 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/34 ,  A61K2300/00

摘要： A novel gene (designated 238P1B2) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238P1B2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 238P1B2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 238P1B2 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因（命名为238P1B2）及其编码的蛋白及其变体，其中238P1B2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，238P1B2提供诊断，预后， 癌症的预防和/或治疗靶标。 238P1B2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与238P1B2反应的抗体或T细胞可用于主动或被动免疫。