公开(公告)号：US06579895B2

公开(公告)日：2003-06-17

申请号：US09866165

申请日：2001-05-25

申请人： Aziz Karim ,  Andrew M. Brugger ,  Ping Gao ,  Fred Hassan ,  James C. Forbes

发明人： Aziz Karim ,  Andrew M. Brugger ,  Ping Gao ,  Fred Hassan ,  James C. Forbes

IPC分类号： A61K31415

CPC分类号： A61K31/415 ,  A61K9/0095 ,  A61K9/14 ,  Y10S977/775 ,  Y10S977/915 ,  Y10S977/926

摘要： There is provided a method of rapidly relieving pain in a mammalian, preferably human, subject. The method comprises orally administering to the subject an effective pain-relieving amount of a composition comprising celecoxib formulated in such a way as to provide, when tested in fasting humans in accordance with standard pharmacokinetic practice, a blood plasma concentration profile of celecoxib in which a concentration of about 250 ng/ml is attained not later than about 30 minutes after oral administration.