公开(公告)号：US20180348235A1

公开(公告)日：2018-12-06

申请号：US15779000

申请日：2016-11-24

Applicant: B.R.A.H.M.S GmbH

Inventor： Bernard VIGUÉ ,  Homa RAFI-NIKOUKHAH

IPC: G01N33/74 ,  G01N33/72

CPC classification number: G01N33/74

Abstract: The present invention relates to a method for determining the extracellular volume status of a subject. The method comprises determining in a sample obtained from a subject the level of the marker proadrenomedullin (proADM) or a fragment thereof, preferably MR-proADM. Further, based on the level of proADM or a fragment thereof, the fluid balance is determined and wherein said fluid balance determines the extracellular volume status. Further, based on the level of proADM or a fragment thereof, the salt balance is determined and wherein said salt balance determines the extracellular volume status and salt retention. Further, the invention relates to a method for in vitro diagnosis, risk stratification, therapy control and/or operative control of a disorder or medical condition in a subject, wherein said extracellular volume status and salt retention of said subject is determined by the herein provided method. Further, the invention relates to a kit and/or a diagnostic device for carrying out the herein provided method.