公开(公告)号：US10093607B2

公开(公告)日：2018-10-09

申请号：US15026878

申请日：2014-10-02

Applicant: BASF SE

Inventor： Eric George Klauber ,  Michael Rack ,  Thomas Zierke ,  Nicole Holub ,  David Cortes ,  Gerald Schmelebeck ,  Junmin Ji

IPC: C07C69/76 ,  C07C51/377 ,  C07C37/02 ,  C07C41/16 ,  C07C67/297 ,  C07F1/00 ,  C07F1/04

Abstract: The present invention relates to a process for providing a compound of formula (I): wherein R is hydrogen or R′, wherein R′ is —(C1-C4)alkyl, and Hal is a halogen, the process comprising the step of: reacting a compound of formula (II) wherein Hal is defined as above, with an alkali metal alkoxide of the formula XOR′, wherein X is an alkali metal, and R′ is defined as above.

公开(公告)号：US12162841B2

公开(公告)日：2024-12-10

申请号：US17323337

申请日：2021-05-18

Applicant: BASF SE

Inventor： Eric George Klauber ,  Michael Rack ,  Roland Goetz ,  Sebastian Soergel

IPC: C07D237/20 ,  C07B31/00 ,  C07B39/00 ,  C07B43/04 ,  C07D237/12 ,  C07D401/12 ,  C07D403/12

Abstract: Provided herein is a process for preparing a pyridazine amine compound of formula V, and a process for preparing dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof. Further, provided herein are dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof, wherein the amino group is an ethylamino group.

公开(公告)号：US20220024898A1

公开(公告)日：2022-01-27

申请号：US17311403

申请日：2020-01-10

Applicant: BASF SE

Inventor： Joachim Gebhardt ,  Martin Viertelhaus ,  Tiziana Chiodo ,  Michael Rack ,  Eric George Klauber ,  Wen Xu ,  Roland Goetz ,  Florian Vogt ,  Birgit Gockel ,  Sebastian Soergel

IPC: C07D403/12 ,  A01N43/58 ,  A01P7/04

Abstract: The present invention relates to a novel crystalline form of 1-(1,2-dimethylpropyl)-N-ethyl-5-methyl-N-pyridazin-4-yl-pyrazole-4-carboxamide recently assigned the common name dimpropyridaz. The invention also relates to the use of the crystalline form B for combating invertebrate pests and to formulations for plant protection which contain the crystalline form B of 1-(1,2-dimethylpropyl)-N-ethyl-5-methyl-N-pyridazin-4-yl-pyrazole-4-carboxamide. The crystalline form B according to the present invention can be identified by powder X-ray diffractometry on the basis of its powder X-ray diffraction diagram, hereinafter also termed powder X-ray diffraction pattern or PXRD pattern, of the polymorph form B recorded using Cu—Kα radiation (1.54178 Å) at 25° C. displays the 3 following reflections, quoted as 2θ values: 20.69±0.10°, 24.15±0.10° and 30.52±0.10°. In addition to these 3 reflections, the polymorph B of the present invention may display in such a PXRD pattern one or more, in particular at least 2, often at least 4, in particular at least 6 or at least 8 reflections and especially all of the reflections quoted hereinafter as 2θ values: 7.99±0.10°, 10.07±0.10°, 12.38±0.10°, 15.31±0.10°, 15.97±0.10°, 16.50±0.10°, 18.03±0.10°, 19.29±0.10°, 20.22±0.0.10°, 20.96±0.10°, 23.40±0.10°, 23.70±0.10°, 26.09±0.10°, 27.26±0.10° and 32.91±0.10°.

公开(公告)号：US11124528B2

公开(公告)日：2021-09-21

申请号：US16608290

申请日：2018-04-25

Applicant: BASF SE

Inventor： Harish Shinde ,  Christopher Koradin ,  Joachim Dickhaut ,  Roland Goetz ,  Michael Rack ,  Eric George Klauber ,  Sukunath Narayanan ,  Dhanyakumar Raut

IPC: C07D513/04 ,  C07D417/04 ,  C07D277/32

Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims or the description.

公开(公告)号：US10961226B2

公开(公告)日：2021-03-30

申请号：US16347414

申请日：2017-10-27

Applicant: BASF SE

Inventor： Eric George Klauber ,  Birgit Gockel ,  Sebastian Soergel ,  Roland Goetz ,  Henricus Maria Martinus Bastiaans ,  Jochen Dietz ,  Joachim Gebhardt

IPC: C07D403/12 ,  A01N43/58

Abstract: The present invention relates to a process for the purification of pyrazolpyridazines of formula I wherein the variables are as defined in the specification, by adding HCl to a solution of the pyrazolpyridazine in an inert solvent under non-aqueous conditions, effecting crystallization of the HCl-salt, isolating the resulting precipitate.

公开(公告)号：US09643909B2

公开(公告)日：2017-05-09

申请号：US15026715

申请日：2014-09-25

Applicant: BASF SE

Inventor： Gerald Schmelebeck ,  Junmin Ji ,  Eric George Klauber ,  Michael Rack ,  Thomas Zierke ,  Nicole Holub ,  David Cortes

IPC: C07C69/00 ,  C07C51/09 ,  C07C37/02 ,  C07C51/15 ,  C07C51/367 ,  C07C67/00 ,  C07F1/00 ,  A01N37/40

CPC classification number: C07C51/09 ,  A01N37/40 ,  C07C37/02 ,  C07C51/15 ,  C07C51/367 ,  C07C67/00 ,  C07F1/005 ,  C07C39/30 ,  C07C65/05 ,  C07C65/21

Abstract: The present invention relates to a process for providing a compound of formula (I): wherein Hal is a halogen, the process comprising the step of: reacting a compound of formula (II) wherein Hal is defined as above, with an alkali metal sulfite of the formula X2SO3 and an alkali metal hydroxide of the formula YOH, wherein X and Y are independently selected from an alkali metal.

公开(公告)号：US20210276959A1

公开(公告)日：2021-09-09

申请号：US17323337

申请日：2021-05-18

Applicant: BASF SE

Inventor： Eric George Klauber ,  Michael Rack ,  Roland Goetz ,  Sebastian Soergel

IPC: C07D237/20 ,  C07D401/12 ,  C07B31/00 ,  C07B39/00 ,  C07B43/04 ,  C07D237/12 ,  C07D403/12

Abstract: Provided herein is a process for preparing a pyridazine amine compound of formula V, and a process for preparing dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof. Further, provided herein are dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof, wherein the amino group is an ethylamino group.

公开(公告)号：US11034703B2

公开(公告)日：2021-06-15

申请号：US16610186

申请日：2018-05-02

Applicant: BASF SE

Inventor： Harish Shinde ,  Christopher Koradin ,  Joachim Dickhaut ,  Roland Goetz ,  Eric George Klauber ,  Sukunath Narayanan ,  Dhanyakumar Raut

IPC: C07D513/04 ,  C07D417/04 ,  C07D401/04 ,  C07D403/04 ,  C07D419/04 ,  C07C403/04

Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims and the description.

公开(公告)号：US10975036B2

公开(公告)日：2021-04-13

申请号：US16074537

申请日：2017-01-25

Applicant: BASF SE

Inventor： Eric George Klauber ,  Michael Rack ,  Sebastian Soergel ,  Birgit Gockel ,  Roland Goetz

IPC: C07D231/14 ,  C07C251/76 ,  C07D401/12 ,  B01J21/18 ,  B01J23/42 ,  C07C249/16 ,  C07D403/12

Abstract: The present invention relates to a catalytic process for preparing pyrazoles of formula V comprising the step of cyclizing hydrazone substituted α,β-unsaturated carbonyl compounds by reacting them with hydrogen in a reaction mixture comprising as components (a) a hydrogenation catalyst, (b) an acid selected from Brønsted acids, ammonium salts of Brønsted acids, and Lewis acids, (c) a protic solvent, and optionally (d) an aprotic solvent.

公开(公告)号：US10584102B2

公开(公告)日：2020-03-10

申请号：US15572303

申请日：2016-05-10

Applicant: BASF SE

Inventor： Eric George Klauber ,  Michael Rack ,  Roland Goetz ,  Sebastian Soergel

IPC: C07D403/12 ,  C07D237/12 ,  C07D237/20 ,  C07B31/00 ,  C07B39/00 ,  C07B43/04

Abstract: Provided herein is a process for preparing a pyridazine amine compound of formula V, and a process for preparing dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof. Further, provided herein are novel dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof, wherein the amino group is an ethylamino group.