公开(公告)号：US10093607B2

公开(公告)日：2018-10-09

申请号：US15026878

申请日：2014-10-02

Applicant: BASF SE

Inventor： Eric George Klauber ,  Michael Rack ,  Thomas Zierke ,  Nicole Holub ,  David Cortes ,  Gerald Schmelebeck ,  Junmin Ji

IPC: C07C69/76 ,  C07C51/377 ,  C07C37/02 ,  C07C41/16 ,  C07C67/297 ,  C07F1/00 ,  C07F1/04

Abstract: The present invention relates to a process for providing a compound of formula (I): wherein R is hydrogen or R′, wherein R′ is —(C1-C4)alkyl, and Hal is a halogen, the process comprising the step of: reacting a compound of formula (II) wherein Hal is defined as above, with an alkali metal alkoxide of the formula XOR′, wherein X is an alkali metal, and R′ is defined as above.

公开(公告)号：US10087133B2

公开(公告)日：2018-10-02

申请号：US15102353

申请日：2014-12-10

Applicant: BASF SE

Inventor： Eric George Klauber ,  Michael Rack ,  Thomas Zierke ,  Nicole Holub ,  David Cortes ,  Gerald Schmelebeck ,  Junmin Ji

IPC: C07C51/367 ,  C07C67/31 ,  C07C45/64 ,  C07C253/30 ,  C07C51/08

Abstract: The present invention relates to a process for providing dihalogen substituted salicylic acid derivatives of formula (II):

公开(公告)号：US09957212B2

公开(公告)日：2018-05-01

申请号：US15119654

申请日：2015-02-19

Applicant: BASF SE

Inventor： Eric George Klauber ,  Michael Rack ,  Thomas Zierke ,  Nicole Holub ,  Gerald Schmelebeck ,  Junmin Ji ,  David Cortes

IPC: C07C37/02 ,  C07C41/16 ,  C07C37/62 ,  C07C51/16 ,  C07C51/285

CPC classification number: C07C41/16 ,  C07C37/02 ,  C07C37/62 ,  C07C51/16 ,  C07C51/285 ,  C07C65/21 ,  C07C43/225 ,  C07C39/30 ,  C07C39/28

Abstract: The present invention relates to a process for providing a compound of formula (IV): wherein R1 and R2 are each independently C1-C4 alkyl, and Hal is independently Cl or Br, the process comprising the steps of: (i) reacting a compound of formula (II) wherein R1 and Hal is defined as above, to obtain a compound of formula (III) wherein R1 and Hal is defined as above, and (ii) reacting the compound of formula (III) to obtain the compound of formula (IV).

公开(公告)号：US09701604B2

公开(公告)日：2017-07-11

申请号：US15101080

申请日：2014-12-01

Applicant: BASF SE

Inventor： Eric George Klauber ,  Michael Rack ,  Thomas Zierke ,  Sebastian Wloch ,  Nicole Holub ,  Stefan Dudenhoeffer ,  Gerald Schmelebeck ,  Junmin Ji ,  David Cortes

IPC: C07C37/70 ,  C07C37/84 ,  C07C37/74

CPC classification number: C07C37/74 ,  C07C37/84 ,  C07C39/30

Abstract: A process for purifying 2,5-dichlorophenol, the process comprising the steps of distillation and subsequent crystallization.

公开(公告)号：US09643909B2

公开(公告)日：2017-05-09

申请号：US15026715

申请日：2014-09-25

Applicant: BASF SE

Inventor： Gerald Schmelebeck ,  Junmin Ji ,  Eric George Klauber ,  Michael Rack ,  Thomas Zierke ,  Nicole Holub ,  David Cortes

IPC: C07C69/00 ,  C07C51/09 ,  C07C37/02 ,  C07C51/15 ,  C07C51/367 ,  C07C67/00 ,  C07F1/00 ,  A01N37/40

CPC classification number: C07C51/09 ,  A01N37/40 ,  C07C37/02 ,  C07C51/15 ,  C07C51/367 ,  C07C67/00 ,  C07F1/005 ,  C07C39/30 ,  C07C65/05 ,  C07C65/21

Abstract: The present invention relates to a process for providing a compound of formula (I): wherein Hal is a halogen, the process comprising the step of: reacting a compound of formula (II) wherein Hal is defined as above, with an alkali metal sulfite of the formula X2SO3 and an alkali metal hydroxide of the formula YOH, wherein X and Y are independently selected from an alkali metal.

公开(公告)号：US09278977B2

公开(公告)日：2016-03-08

申请号：US14220561

申请日：2014-03-20

Applicant: BASF SE

Inventor： Frederik Menges ,  Joachim Gebhardt ,  Michael Rack ,  Michael Keil ,  Rodney F. Klima ,  David Cortes ,  Robert Leicht ,  Helmut Zech ,  Jochen Schroeder

IPC: C07D401/04 ,  C07D213/00 ,  C07D491/048 ,  C07D213/81 ,  C07D405/04 ,  C07D213/803

CPC classification number: C07D491/048 ,  C07D213/803 ,  C07D213/81 ,  C07D401/04 ,  C07D405/04

Abstract: A process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides (I) wherein Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; comprising the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with a chlorinating agent, optionally in the presence of a radical initiator in a solvent selected from halogenated hydrocarbons, and (ii) crystallizing the compound (I) formed in step (i) from a solvent selected from chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, dichloroethane, trichloromethane, dichloromethane, toluene, xylenes, ethyl acetate, methyl tert.-butyl ether, and mixtures thereof. Compounds (I) are useful intermediates in the synthesis of herbicidal imidazolinones.

Abstract translation: 制备其中Z为氢或卤素的5-氯甲基-2,3-吡啶二羧酸酐（I）的方法; Z1是氢，卤素，氰基或硝基; 包括以下步骤：（i）使式（II）化合物（其中符号具有式（I）中给出的含义）与氯化剂反应，任选在自由基引发剂存在下，在选自卤代烃， 和（ii）从选自氯苯，1,2-二氯苯，1,3-二氯苯，1,4-二氯苯，二氯乙烷，三氯甲烷，二氯甲烷，甲苯，二甲苯中的溶剂中，使步骤（i）中形成的化合物（I） ，乙酸乙酯，甲基叔丁基醚及其混合物。 化合物（I）是合成除草咪唑啉酮的有用中间体。