公开(公告)号：US20230322693A1

公开(公告)日：2023-10-12

申请号：US18028129

申请日：2021-09-28

Applicant: BASF SE

Inventor： Christopher Koradin ,  Harish Shinde ,  Martin John McLaughlin ,  Rahul Kaduskar ,  Philipp M. Staehle ,  Roland Goetz ,  Sunil Khamkar

IPC: C07D277/56

CPC classification number: C07D277/56

Abstract: The present invention relates to a process for the preparation 2-chloro-1-(2-chlorothiazol-5-yl)ethanone.

公开(公告)号：US20230145982A1

公开(公告)日：2023-05-11

申请号：US17796291

申请日：2021-02-01

Applicant: BASF SE

Inventor： Florian Vogt ,  Kailaskumar Borate ,  Bernd Wolf ,  Christopher Koradin ,  Joachim Gebhardt ,  Roland Goetz ,  Harish Shinde

IPC: C07D271/06

CPC classification number: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles of formula I, which can be obtained through reaction of amidoxime compounds of formula II with a haloacetic ester in the presence of a solvent and a base.

公开(公告)号：US20140364623A1

公开(公告)日：2014-12-11

申请号：US14371755

申请日：2012-12-13

Applicant: BASF SE

Inventor： Michael Keil ,  Wolfgang Reichert ,  Christopher Koradin ,  Yüksel Battal

IPC: C07D231/12 ,  C07C211/48

CPC classification number: C07D231/12 ,  C07C211/48

Abstract: The present invention relates to a novel process for preparing acetanilides of the formula (I) by reacting a 2-halo-N-halomethylacetanilide of the formula (II) with an azole of the formula (III) H-A  (III) wherein the substituents R, R1, R2, R3, R4, A, X and X1 in the formulae (I), (II) and (III) have the meanings as indicated in the description.

Abstract translation: 本发明涉及一种通过使式（II）的2-卤代-N-卤代甲基乙酰苯胺与式（III）的唑（III）的反应制备式（I）的乙酰苯胺的新方法，其中取代基R 式（I），（II）和（III）中的R 1，R 2，R 3，R 4，A，X和X 1具有如说明书中所示的含义。

公开(公告)号：US20240101547A1

公开(公告)日：2024-03-28

申请号：US18272840

申请日：2022-01-21

Applicant: BASF SE

Inventor： Christopher Koradin ,  Martin John McLaughlin ,  Roland Goetz ,  Rahul Kaduskar ,  Harish Shinde ,  Guillaume Michel Jacques Garivet

IPC: C07D417/12

CPC classification number: C07D417/12

Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof and to its use as intermediate in the preparation of 2,3-dihydrotheiazolo [3,2-a]pyrimidinium compounds, and specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.

公开(公告)号：US20220017931A1

公开(公告)日：2022-01-20

申请号：US17424824

申请日：2020-01-20

Applicant: BASF SE

Inventor： Diego Ghislieri ,  Christian Willrodt ,  Christopher Koradin ,  Stefan Seemayer ,  Doreen Schachtschabel ,  Kai-Uwe Baldenius ,  Roland Goetz

IPC: C12P13/00 ,  C12N9/78

Abstract: Described herein are methods for the production of 4-cyano benzoic acid or salts thereof from terephthalonitrile using nitrilase as catalyst. Also described herein are compositions including 4-cyano benzoic acid.

公开(公告)号：US11034703B2

公开(公告)日：2021-06-15

申请号：US16610186

申请日：2018-05-02

Applicant: BASF SE

Inventor： Harish Shinde ,  Christopher Koradin ,  Joachim Dickhaut ,  Roland Goetz ,  Eric George Klauber ,  Sukunath Narayanan ,  Dhanyakumar Raut

IPC: C07D513/04 ,  C07D417/04 ,  C07D401/04 ,  C07D403/04 ,  C07D419/04 ,  C07C403/04

Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims and the description.

公开(公告)号：US20150018207A1

公开(公告)日：2015-01-15

申请号：US14383731

申请日：2013-03-11

Applicant: BASF SE

Inventor： Torsten Knieriem ,  Tiziana Chiodo ,  Christopher Koradin ,  Tanja Weber ,  Walter Weishaar

IPC: A01N53/00 ,  A01N25/08

CPC classification number: A01N53/00 ,  A01N25/08 ,  A01N43/90 ,  A01N25/04 ,  A01N2300/00

Abstract: The present invention relates to a method for producing an aqueous suspension concentrate formulation and novel suspension concentrate formulations of the compound of formula I. The method comprises: a) providing an aqueous slurry of coarse particles of the compound of the formula I, where the compound of the formula I is at least partially present in its crystalline form B, which, in an X-ray powder diffractogram at 25° C. and Cu-Kα radiation, shows at least three, preferably at least four, in particular at least 5 or at least 7 or at least 9 or all of the following reflexes, given as 2θ values: 8.0±0.2°, 9.5±0.2°, 10.7±0.2°, 11.0±0.2°, 11.2±0.2°, 11.7±0.2°, 14.2±0.2°, 15.6±0.2°, 16.5±0.2°, 17.7±0.2°, 21.5±0.2°; b) comminuting the coarse particles in the slurry of the compound of formula I, which is at least partially present in its form B, in the presence of the at least one surfactant.

Abstract translation: 本发明涉及一种制备水性悬浮液浓缩物制剂的方法和式I化合物的新型悬浮浓缩物制剂。该方法包括：a）提供式I化合物的粗颗粒的含水浆液，其中化合物 式I的至少一部分至少部分以其结晶形式B存在，其在25℃的X射线粉末衍射图和Cu-Kα辐射中显示出至少三个，优选至少四个，特别是至少5个 或至少7个或至少9个或全部以下反射，以2＆ 值：8.0±0.2°，9.5±0.2°，10.7±0.2°，11.0±0.2°，11.2±0.2°，11.7±0.2°，14.2±0.2°，15.6±0.2°，16.5±0.2°，17.7±0.2 °，21.5±0.2°; b）在存在至少一种表面活性剂的情况下粉碎至少部分以其B形式存在的式I化合物的浆料中的粗颗粒。

公开(公告)号：US08592578B2

公开(公告)日：2013-11-26

申请号：US13653615

申请日：2012-10-17

Applicant: BASF SE

Inventor： Thomas Zierke ,  Volker Maywald ,  Michael Rack ,  Sebastian Peer Smidt ,  Michael Keil ,  Bernd Wolf ,  Christopher Koradin

IPC: C07D231/14 ,  C07D265/30 ,  C07D295/145

CPC classification number: C07D231/14 ,  C07C229/30 ,  C07D295/145

Abstract: The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters, 2-(aminomethylidene)-4,4-difluoro-3-oxobutteric esters of the formula (I) in which R1, R2 and R3 independently of one another are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl or NR2R3 is a 5- to 10-membered heterocyclic radical, to a process for preparing compounds of the formula (I) wherein an appropriate 3-aminoacrylic ester is reacted with difluoroacetyl fluoride and to the use of compounds of the formula (I) in the process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters.

Abstract translation: 本发明涉及式（I）的二氟甲基取代的吡唑-4-基羧酸及其酯，2-（氨基亚甲基）-4,4-二氟-3-氧代苦味酯的方法，其中R 1，R 2和 R 3彼此独立地是C 1 -C 6 - 烷基，C 1 -C 6 - 卤代烷基，C 2 -C 6 - 烯基，C 3 -C 10 - 环烷基或苄基或NR 2 R 3是5-至10-元杂环基， 式（I）的化合物，其中适当的3-氨基丙烯酸酯与二氟乙酰氟反应，以及在制备二氟甲基取代的吡唑-4-基羧酸及其酯的方法中使用式（I）的化合物。

公开(公告)号：US20240101575A1

公开(公告)日：2024-03-28

申请号：US18272820

申请日：2022-01-21

Applicant: BASF SE

Inventor： Christopher Koradin ,  Martin John McLaughlin ,  Roland Goetz ,  Rahul Kaduskar ,  Harish Shinde

IPC: C07D513/04

CPC classification number: C07D513/04

Abstract: The present invention relates to a method for preparing an enantiomerically enriched form of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-4-ium-5-olate.

公开(公告)号：US20230028964A1

公开(公告)日：2023-01-26

申请号：US17779262

申请日：2020-11-25

Applicant: BASF SE

Inventor： Kailaskumar Borate ,  Bernd Wolf ,  Florian Vogt ,  Christopher Koradin ,  Roland Goetz ,  Harish Shinde

IPC: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted aromatic carboxamides of formula I, (formula I) which can be obtained through reaction of an aromatic carboxylic acid halide and an amine, whereas the process is conducted in the absence of an auxiliary base in a carboxylic acid ester as solvent.