公开(公告)号：US20240116916A1

公开(公告)日：2024-04-11

申请号：US18272913

申请日：2022-01-21

Applicant: BASF SE

Inventor： Martin John McLaughlin ,  Christopher Koradin ,  Rahul Kaduskar ,  Harish Shinde ,  Roland Gotez ,  Guillaume Michel Jacques Garivet

IPC: C07D417/12 ,  B01J31/18

CPC classification number: C07D417/12 ,  B01J31/1805 ,  C07B2200/07

Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2- hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, and to the use thereof as intermediate in the preparation of 2,3-dihydrothiazolo[3,2-a]pyrimidinium compounds, specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.