公开(公告)号：US20180371444A1

公开(公告)日：2018-12-27

申请号：US16062289

申请日：2016-12-08

Applicant: BASF-SE

Inventor： Max Fabian Felle ,  Stefan Jenewein ,  Handtke Stefan ,  Birgit Voigt ,  Thomas Schweder ,  Michael Hecker

IPC: C12N9/54 ,  C12N15/52 ,  C12N15/113 ,  C12N9/64

Abstract: The present invention generally relates to the field of fermentation technology and microorganisms useful for such fermentations. The invention also relates to materials including nucleic acids and proteins useful for altering fermentation characteristics of microorganisms, and to microorganisms comprising such nucleic acids and/or proteins. In particular, the invention relates to materials for conferring, modifying or reducing microbial stress resistance.

公开(公告)号：US20240317820A1

公开(公告)日：2024-09-26

申请号：US18572974

申请日：2022-06-24

Applicant: BASF SE

Inventor： Max Fabian Felle ,  Christopher Sauer ,  Mathis Appelbaum ,  Stefan Jenewein ,  Tobias Klein ,  Thomas Schweder

IPC: C07K14/32 ,  C12N9/54 ,  C12N15/75

CPC classification number: C07K14/32 ,  C12N9/54 ,  C12N15/75

Abstract: The present invention relates to a Bacillus host cell for increased production of biological compounds. Specifically, the invention relates to a Bacillus host with genetic modifications that lead to decreased production of components of biofilm and increased levels of phosphorylated De-gll. Said Bacillus host comprises at least one gene expression cassette with a polynucleotide encoding at least one polypeptide of interest, operably linked to a promoter for the production of compounds. The present invention further relates to a method for increased production of at least one polypeptide of interest based on cultivating the bacterial host cell of the present invention.

公开(公告)号：US10676728B2

公开(公告)日：2020-06-09

申请号：US16062289

申请日：2016-12-08

Applicant: BASF SE

Inventor： Max Fabian Felle ,  Stefan Jenewein ,  Stefan Handtke ,  Birgit Voigt ,  Thomas Schweder ,  Michael Hecker

IPC: C12N9/54 ,  C12N9/00 ,  C12N9/64 ,  C12N15/113 ,  C12N15/52 ,  C12N9/24 ,  C12N9/08 ,  C12N9/26 ,  C12N9/42

Abstract: The present invention generally relates to the field of fermentation technology and microorganisms useful for such fermentations. The invention also relates to materials including nucleic acids and proteins useful for altering fermentation characteristics of microorganisms, and to microorganisms comprising such nucleic acids and/or proteins. In particular, the invention relates to materials for conferring, modifying or reducing microbial stress resistance.