公开(公告)号：US3595879A

公开(公告)日：1971-07-27

申请号：US3595879D

申请日：1968-10-07

Applicant: BAYER AG

Inventor： PETERSEN SIEGFRIED ,  JUHLING LIESELOTTE ,  TETTENBORN DIETER

IPC: C07D307/52 ,  C07D5/04 ,  C07D5/16

CPC classification number: C07D307/52

Abstract: 2-X,3-Y-1,4-NAPHTHOQUINONE

WHEREIN FUR IS A FURAN OR TETRAHYDROFURAN RADICAL LOWER ALKYL SUBSTITUTED OR NOT, R IS HYDROGEN OR LOWER ALKYL R1 IS ALKYLENE OF 1-4 CARBON ATOMS AND Y IS HYDROGEN HALOGEN OR LOWER ALKOXY, PRODUCED BY REACTING A 1,4NAPHTHOQUINONE OF THE FORMULA:

2-(FUR-R1-N(-R)-),3-Y-1,4-NAPHTHOQUINONE
WHEREIN FUR, R, R1 AND Y HAVE THE ABOVE MEANING AND X IS HYDROGEN, HALOGEN OR LOWER ALKOXY. THE COMPOUNDS ARE USEFUL AS BACTERICIDES, FUNGICIDES AND ANTI-TUMOUR AGENTS FOR ANIMALS EXCLUDING HUMANS. REPRESENTATVE COMPOUNDS ARE 2-FURFURYL-AMINO-1,4-NAPHTHOQUINONE AND THE 3-CHLORO- AND 3-METHOXY-ANALOGS.

R-HN-R''-FUR

NEW AND CHEMOTHERAPEUTICALLY ACTIVE NAPHTHOQUINONE DERIVATIVES ARE PROVIDED OF THE FORMULA:

WITH AN AMINE OF THE FORMULA