公开(公告)号：US3897465A

公开(公告)日：1975-07-29

申请号：US35796473

申请日：1973-05-07

申请人： AIRCO INC

发明人： LEEDS MORTON W ,  SZUR ALEX J

IPC分类号： C07D307/52 ,  C07D5/16

CPC分类号： C07D307/52

摘要： This invention relates to the compound ethyl Beta -(Nmethylfurfurylamino) propionate having the formula:

ITS WATER SOLUBLE SALTS AND A METHOD OF PREPARING THE COMPOUND BY REACTING ETHYL ACRYLATE WITH N-methylfurfurylamine. Compositions containing an effective amount of the compounds of the present invention are useful for tranquilizing and producing analgesia in mammals.

摘要翻译： 本发明涉及具有下式的化合物β-（N-甲基糠基氨基）丙酸乙酯：

公开(公告)号：US3892782A

公开(公告)日：1975-07-01

申请号：US48807374

申请日：1974-07-12

申请人： FIRMENICH & CIE

发明人： BUCHI GEORGE H

IPC分类号： C07D307/36 ,  C07D307/42 ,  C07D5/16

CPC分类号： C07D307/42 ,  C07D307/36

摘要： 2-(Hex-3-cis-en-1-yl)-5-methyl-furan which is a key intermediate in the preparation of cis-jasmone, a perfume principle of jasmin oil, can be prepared in high yield starting from 5-methylfurfural via the formation of 2-(1-hydroxy-but-3-yn-1-yl)-5methyl-furan and 2-(hex-3-yn-1-yl)-5-methyl-furan.

摘要翻译： 作为制备顺式茉莉酮的关键中间体2- [己-3-顺 - 烯-1-基] -5-甲基 - 呋喃，可以从5号开始以高产率制备茉莉酮油的香料原理 - 甲基 - 糠醛通过2- [1-羟基 - 丁-3-炔-1-基] -5-甲基 - 呋喃和2- [己-3-炔-1-基] -5-甲基 - 呋喃。

公开(公告)号：US3888887A

公开(公告)日：1975-06-10

申请号：US46718174

申请日：1974-05-06

申请人： AMERICAN HOME PROD

发明人： JIRKOVSKY IVO L

IPC分类号： C07D307/52 ,  C07D307/66 ,  C07C87/36 ,  C07D5/16

CPC分类号： C07D307/66 ,  C07D307/52

摘要： Enaminoketones characterized by having an amino, arylamino or aryl(lower)alkylamino radical attached to position 3 of a 2-halo2-cyclohexen-1-one with optional di(lower)alkyl groups at position 5 are disclosed. The compounds are useful antibacterial and antifungal agents. Methods for their preparation and use are also disclosed.

公开(公告)号：US3875150A

公开(公告)日：1975-04-01

申请号：US33675873

申请日：1973-02-28

申请人： LEO PHARM PROD LTD

发明人： FEIT PETER WERNER ,  NEILSEN OLE BENT TVAERMOSE

IPC分类号： C07D307/52 ,  C07D333/20 ,  C07D5/16

CPC分类号： C07D333/20 ,  C07D307/52

摘要： This invention relates to new 4-substituted 5-sulfamylanthranilic acids, and salts and esters thereof, having a pronounced diuretic and saluretic effect; to methods of producing the said compounds; and to pharmaceutical compositions in dosage unit from containing the said compounds as active ingredients.

摘要翻译： 本发明涉及新的4-取代的5-磺酰氨基邻氨基苯甲酸及其盐和酯，具有显着的利尿和毒素作用; 涉及制备所述化合物的方法; 和以含有所述化合物作为活性成分的剂量单位的药物组合物。

公开(公告)号：US3849449A

公开(公告)日：1974-11-19

申请号：US28911472

申请日：1972-09-14

申请人： ICI LTD

发明人： DAVIES G

IPC分类号： C07D307/56 ,  C07F5/02 ,  C07D5/16 ,  C07D107/02

CPC分类号： C07D307/56 ,  C07F5/025

摘要： 1. A BORON DERIVATIVE OF THE FORMULA:

1-R3,2-(R1-O2S-),4-R2,6-R-FURO(3,2-D)(1,2,3)DIAZABORINE

WHEREIN R IS HYDROGEN, METHYL OR CHLORINE; R1 IS METHYL, PHENYL OR PHENYL SUBSTITUTED WITH 1 TO 3 SUBSTITUTENTS SELECTED FROM THE GROUP CONSISTING OF HALOGEN, NITRO, AMINO, METHYL, METHOXY, METHYLTHIO AND ACETANIDO; R2 IS HYDROGEN, METHYL OR PHENYL; AND R3 IS HYDROXY.

公开(公告)号：US3821261A

公开(公告)日：1974-06-28

申请号：US28543972

申请日：1972-08-31

申请人： UPJOHN CO

发明人： KAUGARS G

IPC分类号： C07D5/16 ,  C07D5/18

摘要： This invention relates to novel heterocyclic acid chloride phenylhydrazones embraced by the formula

WHEREIN R is a radical selected from the group consisting of furyl, thienyl, and pyridyl, each of which has from zero through three substituents selected from the group consisting of alkyl, halo and nitro, and n is an integer of from zero through three. These compounds are primarily useful as insecticides and miticides and also as herbicides, anti-inflammatories and anthelmintics.

公开(公告)号：US3723476A

公开(公告)日：1973-03-27

申请号：US3789570

申请日：1970-05-15

申请人： YOSHITOMI PHARMACEUTICAL

发明人： NAKANISHI M ,  MURO T ,  IMAMURA H ,  YAMAGUCHI N

IPC分类号： C07D213/30 ,  C07D307/42 ,  C07D333/16 ,  C07D5/16 ,  C07D5/20

CPC分类号： C07D213/30 ,  C07D307/42 ,  C07D333/16

摘要： Phenoxy-aminopropanol derivatives of the formula

WHEREIN R1 is furylmethyl, thienylmethyl, tetrahydrofurylmethyl, pyridylmethyl, or a group of the formula R-X-A-, wherein R is C1 4 alkyl, C1 4 alkenyl, phenyl or benzyl, X is -O- or -S-, and A is C1 4 alkylene or -CH2C*CCH2-; -N(R2)(R3) is C1 4 alkylamino, dialkylamino (each alkyl being at most four carbon atoms), cyclohexylamino, piperidino, morpholino or 4-methyl-1piperazinyl; and R4 is H, CH3 or Cl, and pharmaceutically acceptable acid addition salts thereof, are useful as Beta adrenergic blocking agents.

摘要翻译： 式WHERE R1的苯氧基 - 氨基丙醇衍生物是呋喃基甲基，噻吩基甲基，四氢呋喃基甲基，吡啶基甲基或式RXA-的基团，其中R是C1-4烷基，C1-4链烯基，苯基或苄基，X是-O-或 -S-，A为C 1-4亚烷基或-CH 2 C 3 OCH 3 - ; -N（R 2）（R 3）是C 1-4烷基氨基，二烷基氨基（各烷基至多4个碳原子），环己基氨基，哌啶子基，吗啉代或4-甲基-1-哌嗪基; 并且R 4为H，CH 3或Cl及其药学上可接受的酸加成盐，可用作β-肾上腺素能阻断剂。

公开(公告)号：US3661936A

公开(公告)日：1972-05-09

申请号：US3661936D

申请日：1969-11-13

申请人： US AGRICULTURE

发明人： MOD ROBERT R ,  MAGNE FRANK C ,  SKAU EVALD L

IPC分类号： C07D303/46 ,  C07D307/14 ,  C07D307/52 ,  C08K5/20 ,  C07D5/04 ,  C07D5/16

CPC分类号： C07D307/52 ,  C07D303/46 ,  C07D307/14 ,  C08K5/20 ,  C08L27/06

摘要： THE INVENTION PROVIDES N-METHYL-N-FURFURYL-OLEAMIDE AND N-METHYL-N-TETRAHYDROFURFURYL-OLEAMIDE WHICH ARE USEFUL AS PLASTICIZERS FOR VINYL CHLORIDE RESINS.

公开(公告)号：US3654309A

公开(公告)日：1972-04-04

申请号：US3654309D

申请日：1968-05-22

申请人： FIRMENICH & CIE

发明人： THOMAS ALAN FRANCIS

IPC分类号： A23L27/20 ,  C07C1/22 ,  C07C1/24 ,  C07C29/14 ,  C07C33/03 ,  C07C43/30 ,  C07C45/00 ,  C07C45/51 ,  C07C47/20 ,  C07C47/21 ,  C07C47/225 ,  C07D307/34 ,  C07D307/36 ,  C07D307/42 ,  C07D307/46 ,  C07D333/22 ,  C11B9/00 ,  C07D63/12 ,  C07D5/16

CPC分类号： C07D307/42 ,  A23L27/201 ,  A23L27/2024 ,  C07B2200/09 ,  C07C1/22 ,  C07C29/14 ,  C07C45/00 ,  C07C45/513 ,  C07C403/14 ,  C07C2601/16 ,  C07C2602/42 ,  C07D307/36 ,  C07D307/46 ,  C07D333/22 ,  C11B9/0015 ,  C11B9/0061 ,  C11B9/0073 ,  C07C47/225 ,  C07C47/21 ,  C07C33/02 ,  C07C33/16

摘要： A PROCESS FOR PREPARATION OF A,B-OLEFINICALLY UNSATURATED CARBONYL COMPOUNDS OF FORMULA

R(-C(-R8)=C(-R6)-CH(-R5)-C(-R3)(-R4)-C(-R2)=C(-R1)-CHO

BY CONDENSING, WITH A CONDENSING AGENT AT 60* TO 400* C., A BUTADIENYL ETHER (OR A SUBSTANCE WHICH GENERATES SUCH ETHER) OF FORMULA

R3-C(-R4)=C(-R2)-C(-R1)=CH-O-Y

WHEREIN Y IS A LINEAR OF BRANCHED C1-C4 ALKYL RADICAL, OR A BENZYL, P-NITROBENZYL OR FURFURYL RADICAL AND R1,R2, R3 AND R4 EACH IS HYDROGEN OR A LINEAR OR BRANCHED C1-C6 ALKYL RADICAL, WITH AN ALLYL ALCOHOL CONTAINING AT LEAST THREE CARBON ATOMS AND AT LEAST FOUR CARBON ATOMS LESS THAN THE END PRODUCT, OF FORMULA

R7-C(-R8)=C(-R6)-CH(-R5)-OH

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

公开(公告)号：US3576826A

公开(公告)日：1971-04-27

申请号：US3576826D

申请日：1966-10-10

申请人： PENNWALT CORP

发明人： BAFFORD RICHARD ANTHONY ,  KORCZYKOWSKI LEONARD ERNEST ,  MAGELI ORVILLE LEONARD

IPC分类号： C07C409/20 ,  C07C409/22 ,  C07C409/38 ,  C07C409/40 ,  C08F4/32 ,  C08F4/34 ,  C07C73/00 ,  C07D5/16 ,  C07D7/04

CPC分类号： C08F4/32 ,  C07C407/00 ,  C07C407/003 ,  C07D307/42 ,  C07C409/22 ,  C07C409/20 ,  C07C409/38 ,  C07C409/40

摘要： A PROCESS FOR MAKING ETHER HYDROPEROXIDES BY REACTING, IN THE ABSENCE OF A CATALYST, BELOW ABOUT 60*C., ALPHA-SUBSTITUTED VINYL ETHER WITH ORGANIC PEROXIDE OR HYDROGEN PEROXIDE TO OBTAIN THE CORRESPONDING PEROXIDE

(R3-O-C(-R4-X)(-CH(-R6)-R7)-O-O)P-R24

ILLUSTRATIVE PRODUCT ARE: 2-ETHOXY-2-T-BUTYLPEROXY BUTYRIC ACID; BIS-2,2''-(2-ISOAMYLOXPROPYL) PEROXIDE; 2-ISOAMYL OXY-2-PROPYLPEROXY, ISOPROPYLCARBONATE; 2-METHYL-2-PERBENZOXY TETRAHYDROPYRAN; AND 2-METHYL-2-TETRAHYDROFURYLPEROXY N-METHYL-CARBAMATE.