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    Antihyperglycemic methods and compositions
    1.
    发明授权
    Antihyperglycemic methods and compositions 失效
    抗高血糖方法和组合物

    公开(公告)号：US3879541A

    公开(公告)日：1975-04-22

    申请号：US32421873

    申请日：1973-01-16

    Applicant: BAYER AG

    Inventor： KABBE HANS-JOACHIM ,  HORSTMANN HARALD ,  PLUMPE HANS ,  PULS WALTER ,  PETERSEN SIEGFRIED

    IPC: C07C279/26 ,  A61K27/00

    CPC classification number: C07C279/26

    Abstract: The blood sugar level of hyperglycemic animals can be reduced through administration of an N1-phenylbiguanide which is substituted in the N5-position by the group CH2R2 in which R2 is hydrogen, alkyl of 1 to 7 carbon atoms, alkoxyalkyl of 2 to 5 carbon atoms, cyclohexyl or vinyl, and optionally substituted by one or two groups in the phenyl ring. Solid, orally administered pharmaceutical compositions are also described. A typical embodiment is the use of N1-(4-chlorophenyl)-N5-(npropyl)biguanide hydrochloride which can be administered in a tablet, capsule or dragee.

    Abstract translation: 高血糖动物的血糖水平可以通过施用在N5位被CH2R2（其中R2是氢），1至7个碳原子的烷基，2至5个碳原子的烷氧基烷基的N 2 - 取代的N 1 - 苯基双胍 ，环己基或乙烯基，并且任选被苯环中的一个或两个基团取代。 还描述了固体，口服给药的药物组合物。 典型的实施方案是使用可以在片剂，胶囊或糖衣丸中施用的N1-（4-氯苯基）-N5-（正丙基）双胍盐酸盐。

    Process for the preparation of 1 5-disubstituted-4-cyano-pyrazoles
    2.
    发明授权
    Process for the preparation of 1 5-disubstituted-4-cyano-pyrazoles 失效
    制备1,5-取代-4-氰基 - 吡唑的方法

    公开(公告)号：US3658838A

    公开(公告)日：1972-04-25

    申请号：US3658838D

    申请日：1969-11-10

    Applicant: BAYER AG

    Inventor： KIEHNE HARTMUT ,  PETERSEN SIEGFRIED

    IPC: A01N43/56 ,  C07D231/12 ,  C07D231/14 ,  C07D49/18

    CPC classification number: C07D231/12 ,  C07C255/00 ,  C07D231/14

    Abstract: REACTING A DERIVATIVE OF A B-KETO-NITRILE WITH A SUBSTITUTED HYDRAZINE OR THE CORRESPONDING ACID SALT THEREOF; I.E. AN ENOL ETHER OR ENAMINE OF B-KETONITRILE SUCH AS (ALKOXY-, ALKYLAMINO- AND PHENYLAMINO-METHYLENE)-(OPTIONALLY HALO, TRIFLUOROMETHYL, ALKYL AND/OR ALKOXY SUBSTITUTED-BENZOYL, AND FUROYL)-ACETONITRILE; WITH (OPTIONALLY HYDROXY AND CYANO SUBSTITUTED-ALKYL; CYCLOALKYL; OPTIONALLY CHLORO, NITRO, ALKYL AND/OR DIALKYLSULFONAMIDO SUBSTITUTED-PHENYL; AND PHENYL-ALKYL)-SUBSTITUTED HYDRAZINE, OR THE CORRESPONDING SALT THEREOF; IN THE PRECENCE OF A CARBONXYLIC ACID AT AN ELEVATED TEMPERATURE, E.G. 40-150*C., OPTIONALLY IN THE PRESENCE OF AN INERT SOLVENT; TO FORM THE CORRESPONDING 1,5-DISUBSTITUTED-4-CYANOPYRAZOLE; I.E. 1-(OPTIONALLY HYDROXY AND CYANO SUBSTITUTED-ALKYL; CYCLOALKYL; OPTIONALLY CHLORO, NITRO, ALKYL AND/OR DIALKYLSULFONAMIDO SUBSTITUTED-PHNEYL; AND PHENYL-ALKYL)-4-CYANO - 5 - (OPTIONALLY HALO, TRIFLUOROMETHYL, ALKYL AND/OR ALKOXY SUBSTITUTED-PHENYL, AND FURYL)PYRAZOLES; SOME OF WHICH ARE KNOWN AND ALL OF WHICH ARE FUNGICIDES AND INTERMEDIATES FOR THE PREPARATION OF CROP PROTECTION AGENTS AND PESTICIDES.

    Naphthoquinone derivatives,preparation thereof and chemotherapeutic compositions therewith and their administration
    3.
    发明授权
    Naphthoquinone derivatives,preparation thereof and chemotherapeutic compositions therewith and their administration 失效
    萘醌衍生物，其制备方法及其化疗组合物及其施用

    公开(公告)号：US3595879A

    公开(公告)日：1971-07-27

    申请号：US3595879D

    申请日：1968-10-07

    Applicant: BAYER AG

    Inventor： PETERSEN SIEGFRIED ,  JUHLING LIESELOTTE ,  TETTENBORN DIETER

    IPC: C07D307/52 ,  C07D5/04 ,  C07D5/16

    CPC classification number: C07D307/52

    Abstract: 2-X,3-Y-1,4-NAPHTHOQUINONE

    WHEREIN FUR IS A FURAN OR TETRAHYDROFURAN RADICAL LOWER ALKYL SUBSTITUTED OR NOT, R IS HYDROGEN OR LOWER ALKYL R1 IS ALKYLENE OF 1-4 CARBON ATOMS AND Y IS HYDROGEN HALOGEN OR LOWER ALKOXY, PRODUCED BY REACTING A 1,4NAPHTHOQUINONE OF THE FORMULA:

    2-(FUR-R1-N(-R)-),3-Y-1,4-NAPHTHOQUINONE
    WHEREIN FUR, R, R1 AND Y HAVE THE ABOVE MEANING AND X IS HYDROGEN, HALOGEN OR LOWER ALKOXY. THE COMPOUNDS ARE USEFUL AS BACTERICIDES, FUNGICIDES AND ANTI-TUMOUR AGENTS FOR ANIMALS EXCLUDING HUMANS. REPRESENTATVE COMPOUNDS ARE 2-FURFURYL-AMINO-1,4-NAPHTHOQUINONE AND THE 3-CHLORO- AND 3-METHOXY-ANALOGS.

    R-HN-R''-FUR

    NEW AND CHEMOTHERAPEUTICALLY ACTIVE NAPHTHOQUINONE DERIVATIVES ARE PROVIDED OF THE FORMULA:

    WITH AN AMINE OF THE FORMULA

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