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公开(公告)号：US20230265072A1
公开(公告)日：2023-08-24
申请号：US18134378
申请日：2023-04-13
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK , Thomas MONDRITZKI
IPC分类号： C07D401/14 , C07D401/04
CPC分类号： C07D401/14 , C07D401/04
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
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公开(公告)号：US20210139555A1
公开(公告)日：2021-05-13
申请号：US17046509
申请日：2019-04-10
发明人： Anke MAYER-BARTSCHMID , Damian BROCKSCHNIEDER , Marcel GEERTZ , Simone GREVEN , Lucas Hudson HOFMEISTER , Hannah JÖRISSEN , Christoph MAHLERT , Tobias MARQUARDT , Ilka MATHAR , Thomas MONDRITZKI , Claudia NOACK , Jan TEBBE , Stuart WALSH , Ernst WEBER , Andreas WILMEN , Frank WUNDER
摘要： The present invention relates to an antibody or a fragment thereof comprising at least one heterologous amino acid sequence incorporated within at least one CDR region of said antibody or fragment thereof, wherein said at least one heterologous amino acid sequence comprises an N-terminal linker sequence (Nils), an Atrial Natriuretic Peptide (ANP) and a C-terminal linker sequence (Ctls). Optionally, at least a portion of said at least one CDR region is replaced by said at least one heterologous amino acid sequence incorporated therein. The present invention further relates to such antibody or fragment thereof for use in a method for treatment, a composition comprising such antibody or fragment thereof, a nucleic acid or a mixture of nucleic acids encoding such antibody or fragment thereof, a host cell comprising such nucleic acid or such mixture of nucleic acids and to a process for producing such antibody or fragment thereof.
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公开(公告)号：US20220274958A1
公开(公告)日：2022-09-01
申请号：US17667410
申请日：2022-02-08
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK , Thomas MONDRITZKI
IPC分类号： C07D401/14 , C07D401/04
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
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公开(公告)号：US20240109864A1
公开(公告)日：2024-04-04
申请号：US18256645
申请日：2021-12-09
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK
IPC分类号： C07D401/14 , A61P9/12 , C07D401/04
CPC分类号： C07D401/14 , A61P9/12 , C07D401/04
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
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公开(公告)号：US20240051935A1
公开(公告)日：2024-02-15
申请号：US18256647
申请日：2021-12-09
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK , Thomas MONDRITZKI
IPC分类号： C07D401/04 , A61P9/12 , A61P9/00
CPC分类号： C07D401/04 , A61P9/12 , A61P9/00
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
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公开(公告)号：US20240101528A1
公开(公告)日：2024-03-28
申请号：US18256650
申请日：2021-12-09
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK
IPC分类号： C07D401/04 , C07D405/14 , C07D401/14 , A61P9/12 , A61P9/08
CPC分类号： C07D401/04 , C07D405/14 , C07D401/14 , A61P9/12 , A61P9/08
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
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公开(公告)号：US20230027985A1
公开(公告)日：2023-01-26
申请号：US17776961
申请日：2020-11-12
发明人： Daniel MEIBOM , Yolanda CANCHO GRANDE , Pierre WASNAIRE , Sarah Anna Liesa JOHANNES , Niels LINDNER , Kristin BEYER , Till FREUDENBERGER , Damian BROCKSCHNIEDER , Ilka MATHAR , Jürgen KLAR , Dmitry ZUBOV , Dzianis MENSHYKAU , Tanja KRAINZ , Eric STEFAN , Bryan MACDONALD , Yi XING , Nadine ELOWE , Guzman SANCHEZ
IPC分类号： C07D403/14 , C07D409/14 , C07D417/14 , C07D401/14 , C07D403/12 , A61K45/06
摘要： The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, 5- to 6-membered heteroaryl or phenyl; R2 is hydrogen or alkyl; A is 5-membered heteroaryl; Z is 6- to 10-membered aryl or 5- to 10-membered heteroaryl; all groups being optionally substituted.
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