-
公开(公告)号：US20230265072A1
公开(公告)日：2023-08-24
申请号：US18134378
申请日：2023-04-13
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK , Thomas MONDRITZKI
IPC分类号： C07D401/14 , C07D401/04
CPC分类号： C07D401/14 , C07D401/04
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
-
公开(公告)号：US20200338096A1
公开(公告)日：2020-10-29
申请号：US16758742
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Hana CERNECKA , Karoline DROEBNER , Hanna TINEL , Anja BUCHMUELLER , Thomas MONDRITZKI , Axel KRETSCHMER , Klemens LUSTIG , Robert FRICKE , Guillaume LEVILAIN , Ursula KRENZ , Norbert WITOWSKI
IPC分类号： A61K31/675 , A61K45/06 , C07F9/6558 , A61P13/12
摘要： The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US20240109864A1
公开(公告)日：2024-04-04
申请号：US18256645
申请日：2021-12-09
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK
IPC分类号： C07D401/14 , A61P9/12 , C07D401/04
CPC分类号： C07D401/14 , A61P9/12 , C07D401/04
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
-
公开(公告)号：US20240051935A1
公开(公告)日：2024-02-15
申请号：US18256647
申请日：2021-12-09
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK , Thomas MONDRITZKI
IPC分类号： C07D401/04 , A61P9/12 , A61P9/00
CPC分类号： C07D401/04 , A61P9/12 , A61P9/00
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
-
公开(公告)号：US20230115270A1
公开(公告)日：2023-04-13
申请号：US17774459
申请日：2020-11-05
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Lisa DIETZ , Magdalena PLATZK , Daniel MEIBOM , Philipp BUCHGRABER , Niels LINDNER , Eva Maria BECKER-PELSTER , Carsten SCHMECK
IPC分类号： C07D417/12 , C07D413/12 , C07D277/28
摘要： The present application relates to novel substituted heterocyclic carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of breathing difficulties including sleep-induced breathing difficulties such as central and obstructive sleep apnoea, snoring (primary and obstructive snoring), dysphagia, peripheral and cardiac vascular disorders including diabetic microangiopathies and disorders of the peripheral and central nervous system including neurodegenerative and neuroinflammatory disorders.
-
公开(公告)号：US20200230136A1
公开(公告)日：2020-07-23
申请号：US16608710
申请日：2018-04-19
IPC分类号： A61K31/506 , A61K31/541 , A61K31/5377 , A61P9/10
摘要： The invention relates to selective adrenoreceptor α2C receptor antagonists alone, or in combination with chymase inhibitors for use in the treatment and/or prophylaxis of peripheral artery diseases (PAD) and/or critical limb ischemia (CLI).
-
公开(公告)号：US20240101528A1
公开(公告)日：2024-03-28
申请号：US18256650
申请日：2021-12-09
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK
IPC分类号： C07D401/04 , C07D405/14 , C07D401/14 , A61P9/12 , A61P9/08
CPC分类号： C07D401/04 , C07D405/14 , C07D401/14 , A61P9/12 , A61P9/08
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
-
公开(公告)号：US20230065629A1
公开(公告)日：2023-03-02
申请号：US17519329
申请日：2021-11-04
发明人： Anja GIESE , Jürgen KLAR , Alexander Helmut Michael EHRMANN , Jens WILLWACHER , David ENGEL , Andre Philippe DIESKAU , Antje KAHNERT , Alexey GROMOV , Carsten SCHMECK , Niels LINDNER , Thomas MÜLLER , Anna Lena ANDREEVSKI , Jan DREHER , Karl COLLINS
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.
-
公开(公告)号：US20190144422A1
公开(公告)日：2019-05-16
申请号：US16098202
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Carsten SCHMECK , Pierre WASNAIRE , Hanna TINEL , Heiko SCHIRMER
IPC分类号： C07D401/14 , A61K31/4196 , C07D417/14 , C07D403/14 , A61K45/06 , A61K31/4439 , A61K31/427 , A61K31/497 , A61K31/501 , A61P13/12 , A61P9/12 , A61P9/10
CPC分类号： C07D401/14 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K45/06 , A61P9/10 , A61P9/12 , A61P13/12 , C07D403/14 , C07D417/14
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-heteroaryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US20220274958A1
公开(公告)日：2022-09-01
申请号：US17667410
申请日：2022-02-08
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK , Thomas MONDRITZKI
IPC分类号： C07D401/14 , C07D401/04
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.017 秒)
