公开(公告)号：US20200375986A1

公开(公告)日：2020-12-03

申请号：US16761713

申请日：2018-10-31

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Nicole BIBER ,  Damian BROCKSCHNIEDER ,  Florian KÖLLING ,  Jörg MEDING ,  Hideki MIYATAKE ONDOZABAL ,  Thomas NEUBAUER ,  Martina SCHÄFER ,  Dmitry ZUBOV ,  Carsten TERJUNG

IPC分类号： A61K31/4985 ,  A61K45/06 ,  C07D487/04 ,  A61P11/00

摘要： The invention relates to prolyl endopeptidase (PREP) inhibitors which contain a condensed 2,4-dihydro-3H-1,2,4-triazol-3-one ring system, methods for producing same, the use thereof alone or in combinations for treating and/or preventing diseases, and the use thereof for producing drugs for treating and/or preventing diseases, in particular for treating and/or preventing inflammatory lung diseases (COPD).

公开(公告)号：US20190160048A1

公开(公告)日：2019-05-30

申请号：US16300480

申请日：2017-05-08

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Nicole BIBER ,  Damian BROCKSCHNIEDER ,  Kersten Matthias GERICKE ,  Florian KÖLLING ,  Klemens LUSTIG ,  Jörg MEDING ,  Heinrich MEIER ,  Thomas NEUBAUER ,  Martina SCHÄFER ,  Andreas TIMMERMANN ,  Dmitry ZUBOV ,  Carsten TERJUNG ,  Niels LINDNER ,  Volker BADOCK ,  Dieter MOOSMAYER ,  Hideki MIYATAKE ONDOZABAL ,  Steven MOORE ,  Alexander SCHULZ

IPC分类号： A61K31/437 ,  A61P29/00 ,  A61P11/00 ,  C07D471/04 ,  A61K31/506

摘要： The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.