公开(公告)号：US20200375986A1

公开(公告)日：2020-12-03

申请号：US16761713

申请日：2018-10-31

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Nicole BIBER ,  Damian BROCKSCHNIEDER ,  Florian KÖLLING ,  Jörg MEDING ,  Hideki MIYATAKE ONDOZABAL ,  Thomas NEUBAUER ,  Martina SCHÄFER ,  Dmitry ZUBOV ,  Carsten TERJUNG

IPC分类号： A61K31/4985 ,  A61K45/06 ,  C07D487/04 ,  A61P11/00

摘要： The invention relates to prolyl endopeptidase (PREP) inhibitors which contain a condensed 2,4-dihydro-3H-1,2,4-triazol-3-one ring system, methods for producing same, the use thereof alone or in combinations for treating and/or preventing diseases, and the use thereof for producing drugs for treating and/or preventing diseases, in particular for treating and/or preventing inflammatory lung diseases (COPD).

公开(公告)号：US20190160048A1

公开(公告)日：2019-05-30

申请号：US16300480

申请日：2017-05-08

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Nicole BIBER ,  Damian BROCKSCHNIEDER ,  Kersten Matthias GERICKE ,  Florian KÖLLING ,  Klemens LUSTIG ,  Jörg MEDING ,  Heinrich MEIER ,  Thomas NEUBAUER ,  Martina SCHÄFER ,  Andreas TIMMERMANN ,  Dmitry ZUBOV ,  Carsten TERJUNG ,  Niels LINDNER ,  Volker BADOCK ,  Dieter MOOSMAYER ,  Hideki MIYATAKE ONDOZABAL ,  Steven MOORE ,  Alexander SCHULZ

IPC分类号： A61K31/437 ,  A61P29/00 ,  A61P11/00 ,  C07D471/04 ,  A61K31/506

摘要： The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.

公开(公告)号：US20230112499A1

公开(公告)日：2023-04-13

申请号：US17786268

申请日：2020-12-14

申请人： Bayer Aktiengesellschaft

发明人： Olaf PANKNIN ,  Frank SACHER ,  Nicole SCHMIDT ,  Gernot LANGER ,  Katrin NOWAK-REPPEL ,  Reinhard NUBBEMEYER ,  Sabine PILARI ,  Antje ROTTMANN ,  Hideki MIYATAKE ONDOZABAL ,  Holger SIEBENEICHER ,  Antonius TER LAAK ,  Hana CERNECKA

IPC分类号： C07D491/048 ,  C07D519/00

摘要： The present invention covers furoindazole compounds of general formula (I): in which (I) are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of autoimmune diseases such as multiple sclerosis, psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, primary and secondary autoimmune uveitis, inflammatory disorders like endometriosis, inflammatory eye diseases, inflammatory kidney diseases, inflammatory liver diseases like non-alcoholic, alcoholic- and toxic fatty liver diseases, lung diseases like asthma, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and metabolic and metabolic-endocrine disorders like metabolic syndrome, insulin resistance, diabetes mellitus type I and type II, and polycystic ovary syndrome (PCOS) disorders, neuropathic and inflammatory pain disorders in humans and animals.