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公开(公告)号：US20200375986A1
公开(公告)日：2020-12-03
申请号：US16761713
申请日：2018-10-31
发明人： Nicole BIBER , Damian BROCKSCHNIEDER , Florian KÖLLING , Jörg MEDING , Hideki MIYATAKE ONDOZABAL , Thomas NEUBAUER , Martina SCHÄFER , Dmitry ZUBOV , Carsten TERJUNG
IPC分类号： A61K31/4985 , A61K45/06 , C07D487/04 , A61P11/00
摘要： The invention relates to prolyl endopeptidase (PREP) inhibitors which contain a condensed 2,4-dihydro-3H-1,2,4-triazol-3-one ring system, methods for producing same, the use thereof alone or in combinations for treating and/or preventing diseases, and the use thereof for producing drugs for treating and/or preventing diseases, in particular for treating and/or preventing inflammatory lung diseases (COPD).
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公开(公告)号：US20240010684A1
公开(公告)日：2024-01-11
申请号：US18035493
申请日：2021-10-29
发明人： Donald BIERER , Ingo FLAMME , Dmitry ZUBOV , Thomas NEUBAUER , Adrian TERSTEEGEN , Lars BAUMANN , Cathleen JUHL , Marie GLATZ , Jan DREHER , Simon HOLTON , Jiancheng XIONG , Jianchao XU
摘要： The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
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![SUBSTITUTED 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3(2H)-ONES AND 2,5,6,7-TETRAHYDRO-3H-PYRROLO[2,1-C][1,2,4]TRIAZOL-3-ONES, AND USE THEREOF](/abs-image/US/2019/05/30/US20190160048A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190160048A1
公开(公告)日：2019-05-30
申请号：US16300480
申请日：2017-05-08
发明人： Nicole BIBER , Damian BROCKSCHNIEDER , Kersten Matthias GERICKE , Florian KÖLLING , Klemens LUSTIG , Jörg MEDING , Heinrich MEIER , Thomas NEUBAUER , Martina SCHÄFER , Andreas TIMMERMANN , Dmitry ZUBOV , Carsten TERJUNG , Niels LINDNER , Volker BADOCK , Dieter MOOSMAYER , Hideki MIYATAKE ONDOZABAL , Steven MOORE , Alexander SCHULZ
IPC分类号： A61K31/437 , A61P29/00 , A61P11/00 , C07D471/04 , A61K31/506
摘要： The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.
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公开(公告)号：US20210246166A1
公开(公告)日：2021-08-12
申请号：US17138447
申请日：2020-12-30
发明人： Donald BIERER , Ingo FLAMME , Dmitry ZUBOV , Thomas NEUBAUER , Adrian TERSTEEGEN , Cathleen JUHL , Marie GLATZ , Jan DREHER , Simon HOLTON , Carsten TERJUNG , Lars BAUMANN , Thorsten POETHKO , Jiancheng XIONG , Yibo QIU
摘要： The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
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公开(公告)号：US20170020875A1
公开(公告)日：2017-01-26
申请号：US15288982
申请日：2016-10-07
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/506 , A61K45/06 , C07D405/14 , C07D413/04 , A61K31/538 , C07D401/04 , A61K31/536 , C07D409/14 , C07D417/14 , C07D403/04 , C07D417/04
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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公开(公告)号：US20160237160A1
公开(公告)日：2016-08-18
申请号：US14898455
申请日：2014-06-12
发明人： Christian VOTSMEIER , Stefanie HAMMER , Uwe GRITZAN , Sandra BERNDT , Dmitry ZUBOV , Lars LINDEN , Sven CHRISTIAN , Axel HARRENGA , Jörg BIRKENFELD , Christoph FREIBERG , Sven GOLFIER , Andrea EICKER , Simone GREVEN , Beatrix STELTE-LUDWIG , Marian RASCHKE
IPC分类号： C07K16/28 , A61K49/00 , A61K31/44 , A61K31/4745 , A61K31/282 , A61K31/513 , A61K47/48 , A61K39/395
CPC分类号： C07K16/2878 , A61K31/282 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K39/39558 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K49/0032 , A61K49/0058 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/75 , C07K2317/77 , C07K2317/92
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the TWEAKR (TNFRSF12A, FN14). The antibodies, accordingly, can be used to treat tumors and other disorders and conditions associated with expression of the TWEAKR. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for us.
摘要翻译： 本发明提供重组抗原结合区和包含特异于TWEAKR（TNFRSF12A，FN14）的抗原结合区的抗体和功能片段。 因此，抗体可用于治疗与TWEAKR表达相关的肿瘤和其它病症和病症。 本发明还提供编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有我们说明书的试剂盒。
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公开(公告)号：US20150183773A1
公开(公告)日：2015-07-02
申请号：US14643209
申请日：2015-03-10
发明人： Mario JESKE , Dirk HEIMBACH , Susanne RÖHRIG , Yolanda CANCHO GRANDE , Dirk SCHNEIDER , Ulrich RESTER , Eckhard BENDER , Mark MEININGHAUS , Katja ZIMMERMANN , Dmitry ZUBOV , Anja BUCHMÜLLER , Georges VON DEGENFELD , Christoph GERDES , Michael GERISCH , Mark Jean GNOTH , Kersten Matthias GERICKE
IPC分类号： C07D417/06 , A61K31/451 , C07D405/06 , A61K31/453 , A61K31/4525 , A61K31/541 , C07D401/06 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/496 , C07D211/60 , A61K31/4523
CPC分类号： C07D417/06 , A61K9/0019 , A61K9/10 , A61K9/2018 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/10 , A61K47/36 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders and tumour disorders.
摘要翻译： 本发明涉及新的取代的哌啶，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管疾病和肿瘤的药物的用途 疾病
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公开(公告)号：US20170020876A1
公开(公告)日：2017-01-26
申请号：US15288968
申请日：2016-10-07
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/513 , A61K31/538
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
摘要翻译： 本申请涉及新颖的双环取代的尿嘧啶衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产用于治疗和/或预防 疾病
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公开(公告)号：US20200061063A1
公开(公告)日：2020-02-27
申请号：US16373487
申请日：2019-04-02
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/513 , C07D413/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , A61K45/06 , C07D405/14 , C07D417/14 , A61K31/538 , A61K31/506 , A61K31/536
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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公开(公告)号：US20180256576A1
公开(公告)日：2018-09-13
申请号：US15912185
申请日：2018-03-05
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/513 , C07D403/04 , C07D417/14 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D471/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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