公开(公告)号：US20240010684A1

公开(公告)日：2024-01-11

申请号：US18035493

申请日：2021-10-29

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Donald BIERER ,  Ingo FLAMME ,  Dmitry ZUBOV ,  Thomas NEUBAUER ,  Adrian TERSTEEGEN ,  Lars BAUMANN ,  Cathleen JUHL ,  Marie GLATZ ,  Jan DREHER ,  Simon HOLTON ,  Jiancheng XIONG ,  Jianchao XU

IPC分类号： C07K7/54 ,  A61P9/10

CPC分类号： C07K7/54 ,  A61P9/10

摘要： The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.