公开(公告)号：US20240010684A1

公开(公告)日：2024-01-11

申请号：US18035493

申请日：2021-10-29

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Donald BIERER ,  Ingo FLAMME ,  Dmitry ZUBOV ,  Thomas NEUBAUER ,  Adrian TERSTEEGEN ,  Lars BAUMANN ,  Cathleen JUHL ,  Marie GLATZ ,  Jan DREHER ,  Simon HOLTON ,  Jiancheng XIONG ,  Jianchao XU

IPC分类号： C07K7/54 ,  A61P9/10

CPC分类号： C07K7/54 ,  A61P9/10

摘要： The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.

公开(公告)号：US20200055842A1

公开(公告)日：2020-02-20

申请号：US16341410

申请日：2017-10-09

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Anja GIESE ,  Jürgen KLAR ,  Alexander Helmut Michael EHRMANN ,  Jens WILLWACHER ,  David ENGEL ,  Andre Philippe DIESKAU ,  Antje KAHNERT ,  Alexey GROMOV ,  Carsten SCHMECK ,  Niels LINDNER ,  Thomas MÜLLER ,  Anna Lena ANDREEVSKI ,  Jan DREHER ,  Karl COLLINS

IPC分类号： C07D403/14 ,  C07D401/14 ,  C07D487/04 ,  C07D405/14 ,  C07D413/14

摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20230065629A1

公开(公告)日：2023-03-02

申请号：US17519329

申请日：2021-11-04

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Anja GIESE ,  Jürgen KLAR ,  Alexander Helmut Michael EHRMANN ,  Jens WILLWACHER ,  David ENGEL ,  Andre Philippe DIESKAU ,  Antje KAHNERT ,  Alexey GROMOV ,  Carsten SCHMECK ,  Niels LINDNER ,  Thomas MÜLLER ,  Anna Lena ANDREEVSKI ,  Jan DREHER ,  Karl COLLINS

IPC分类号： C07D403/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04

摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20210246166A1

公开(公告)日：2021-08-12

申请号：US17138447

申请日：2020-12-30

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Donald BIERER ,  Ingo FLAMME ,  Dmitry ZUBOV ,  Thomas NEUBAUER ,  Adrian TERSTEEGEN ,  Cathleen JUHL ,  Marie GLATZ ,  Jan DREHER ,  Simon HOLTON ,  Carsten TERJUNG ,  Lars BAUMANN ,  Thorsten POETHKO ,  Jiancheng XIONG ,  Yibo QIU

IPC分类号： C07K7/08 ,  A61K45/06 ,  A61K38/10 ,  A61P13/12

摘要： The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.