公开(公告)号：US20160280648A1

公开(公告)日：2016-09-29

申请号：US15033987

申请日：2014-11-11

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed MORADI ,  Thomas HIMMLER ,  Thomas Norbert MUELLER ,  Albert SCHNATTERER ,  Guenter SCHLEGEL

IPC: C07D213/56

CPC classification number: C07D213/56 ,  C07D213/38 ,  C07D213/57 ,  C07D213/89

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluorometyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluorometyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.

Abstract translation: 本发明涉及取代的2-甲基氰基吡啶衍生物，特别是3-氯-5-（三氟甲基）吡啶-2-基]乙腈[= Py-CN]到取代的2-乙基氨基吡啶衍生物的催化氢化，特别是 2- [3-氯-5-（三氟甲基）吡啶-2-基]乙胺[= Py-乙胺]或其盐在金属催化剂，特别是钯催化剂存在下。

公开(公告)号：US20200039936A1

公开(公告)日：2020-02-06

申请号：US16471144

申请日：2017-12-18

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed MORADI ,  Thomas HIMMLER ,  Thomas Norbert MUELLER

IPC: C07D213/26 ,  C07D213/40

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of Raney catalysts, in particular Raney nickel or cobalt.