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7 条记录 (耗时 0.041 秒)

    SUBSTITUTED IMIDAZOPYRIDAZINES
    1.
    发明申请
    SUBSTITUTED IMIDAZOPYRIDAZINES 有权
    取代的咪唑吡啶

    公开(公告)号：US20140228370A1

    公开(公告)日：2014-08-14

    申请号：US14346859

    申请日：2012-09-20

    申请人： BAYER INTELLECTUAL PROPERTY GMBH

    发明人： Knut Eis ,  Florian Puehler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther

    IPC分类号： A61K31/5025 ,  C07D491/048 ,  A61K45/06 ,  C07D487/04

    CPC分类号： A61K31/5025 ,  A61K45/06 ,  C07D487/04 ,  C07D491/048

    摘要： The present invention relates to substituted imidazopyridazine compounds of general formula (I): in which A, Q, R1, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

    摘要翻译： 本发明涉及通式（I）的取代的咪唑并哒嗪化合物：其中A，Q，R 1，R 3，R 4和n如权利要求中所定义，涉及制备所述化合物的方法，可用于制备所述化合物的中间体化合物 涉及包含所述化合物的药物组合物和组合，以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物作为唯一试剂或组合的用途 与其他活性成分。

    AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES
    2.
    发明申请
    AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES 有权
    氨基取代的咪唑吡啶

    公开(公告)号：US20140364435A1

    公开(公告)日：2014-12-11

    申请号：US14364181

    申请日：2012-12-10

    申请人： Bayer Intellectual Property GmbH

    发明人： Knut Eis ,  Florian Puehler ,  Ludwig Zorn ,  Volker Schulze ,  Detlev Sülzle ,  Philip Lienau ,  Andrea Hagebarth ,  Kirstin Petersen ,  Ulf Bomer

    IPC分类号： C07D491/048 ,  A61K45/06 ,  A61K31/5025

    CPC分类号： C07D491/048 ,  A61K31/5025 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to amino-substituted imidazopyndazine compounds of general formula (I): in which A, R1, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

    摘要翻译： 本发明涉及通式（I）的氨基取代的咪唑并二嗪化合物：其中A，R 1，R 2，R 3，R 4和n如权利要求中所定义，涉及制备所述化合物的方法，可用于制备 所述化合物，包含所述化合物的药物组合物和组合以及用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物的所述化合物用作单一药剂或 与其他活性成分组合。

    Substituted imidazopyridazines
    5.
    发明授权
    Substituted imidazopyridazines 有权
    取代咪唑并哒嗪

    公开(公告)号：US09320737B2

    公开(公告)日：2016-04-26

    申请号：US14346859

    申请日：2012-09-20

    申请人： Bayer Intellectual Property GmbH

    发明人： Knut Eis ,  Florian Puehler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther

    IPC分类号： C07D487/04 ,  C07D491/04 ,  A61K31/5025 ,  A61P35/00 ,  A61K45/06 ,  C07D491/048

    CPC分类号： A61K31/5025 ,  A61K45/06 ,  C07D487/04 ,  C07D491/048

    摘要： The present invention relates to substituted imidazopyridazine compounds of general formula (I): in which A, Q, R1, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

    摘要翻译： 本发明涉及通式（I）的取代的咪唑并哒嗪化合物：其中A，Q，R 1，R 3，R 4和n如权利要求中所定义，涉及制备所述化合物的方法，可用于制备所述化合物的中间体化合物 涉及包含所述化合物的药物组合物和组合，以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物作为唯一试剂或组合使用 与其他活性成分。

    AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES
    6.
    发明申请
    AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES 有权
    氨基取代的咪唑吡啶

    公开(公告)号：US20150087631A1

    公开(公告)日：2015-03-26

    申请号：US14388940

    申请日：2013-03-27

    申请人： Bayer Intellectual Property GmbH

    发明人： Knut Eis ,  Florian Puehler ,  Ludwig Zorn ,  Volker Schulze ,  Detlev Sülzle ,  Philip Lienau ,  Andrea Hägebarth ,  Kirstin Petersen ,  Ulf Bömer

    IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K31/5377

    CPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K31/5377

    摘要： The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I), in which A, R1, R2, R3, R4, R5 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

    摘要翻译： 本发明涉及通式（I）的氨基取代的咪唑并哒嗪化合物，其中A，R 1，R 2，R 3，R 4，R 5和n如权利要求中所定义，涉及制备所述化合物的方法， 用于制备所述化合物的药物组合物和包含所述化合物的组合物以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物作为唯一的用途 药剂或与其他活性成分组合。