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1.发明申请18-METHYL-6,7-METHYLENE-3-OXO-17-PREGN-4-ENE-21,17B-CARBOLACTONES, PHARMACEUTICAL PREPARATIONS COMPRISING SAID COMPOUNDS AND USE THEREOF IN THE TREATMENT OF ENDOMETRIOSIS 审中-公开18-甲基-6,7-甲基-3-氧代-17-孕酮-4-烯-21,17B-羧酸酯，包含上述化合物的药物制剂及其在治疗子宫内膜异位症中的用途公开(公告)号：US20140288035A1
公开(公告)日：2014-09-25
申请号：US14356165
申请日：2012-11-02
发明人： Jan Hübner , Rolf Bohlmann , Isabella Gashaw , Oliver Martin Fischer , Joachim Kuhnke , Norbert Gallus , Reinhard Nubbemeyer , Ildiko Terebesi
IPC分类号： C07J53/00 , A61K31/585
CPC分类号： C07J53/007 , A61K31/585
摘要： The present invention relates to 18-methyl-6,7-methylene-17-pregn-4-ene-21,17β-carbolactones of general formula I wherein the 6,7-methylene group can be in α- or β position, pharmaceutical preparations containing at least one isomer of formula I and use thereof in the treatment of endometriosis.
摘要翻译： 本发明涉及通式I的18-甲基-6,7-亚甲基-17-孕-4-烯-21,17-二碳代内酯，其中该6,7-亚甲基可以是α-或β- 位置，含有至少一种式I异构体的药物制剂及其用于治疗子宫内膜异位症的用途。
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2.发明授权Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, processes for their preparation, pharmaceutical preparations comprising them and their use for preparing medicaments 有权Estra-1,3,5（10），16-四烯-3-甲酰胺衍生物，其制备方法，包含它们的药物制剂及其制备药物的用途公开(公告)号：US09487554B2
公开(公告)日：2016-11-08
申请号：US14348645
申请日：2012-09-24
发明人： Ulrich Bothe , Naomi Barak , Matthias Busemann , Oliver Martin Fischer , Andrea Rotgeri , Isabella Gashaw , Ingo Hartung , Tobias Marquardt
CPC分类号： C07J43/003 , A61K31/58 , A61K45/06
摘要： The invention relates to AKR1C3 inhibitors and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular bleeding disorders and endometriosis.
摘要翻译： 本发明涉及AKR1C3抑制剂及其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是出血性疾病和子宫内膜异位症的药物的用途。
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3.发明申请Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, processes for their preparation, pharmaceutical preparations comprising them and their use for preparing medicaments 有权Estra-1,3,5（10），16-四烯-3-甲酰胺衍生物，其制备方法，包含它们的药物制剂及其制备药物的用途公开(公告)号：US20140249119A1
公开(公告)日：2014-09-04
申请号：US14348645
申请日：2012-09-24
发明人： Ulrich Bothe , Naomi Barak , Matthias Busemann , Oliver Martin Fischer , Andrea Rotgeri , Isabella Gashaw , Ingo Hartung , Tobias Marquardt
CPC分类号： C07J43/003 , A61K31/58 , A61K45/06
摘要： The invention relates to AKR1C3 inhibitors and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular bleeding disorders and endometriosis.
摘要翻译： 本发明涉及AKR1C3抑制剂及其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是出血性疾病和子宫内膜异位症的药物的用途。
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