-
1.发明授权Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, processes for their preparation, pharmaceutical preparations comprising them and their use for preparing medicaments 有权Estra-1,3,5（10），16-四烯-3-甲酰胺衍生物，其制备方法，包含它们的药物制剂及其制备药物的用途公开(公告)号：US09487554B2
公开(公告)日：2016-11-08
申请号：US14348645
申请日：2012-09-24
发明人： Ulrich Bothe , Naomi Barak , Matthias Busemann , Oliver Martin Fischer , Andrea Rotgeri , Isabella Gashaw , Ingo Hartung , Tobias Marquardt
CPC分类号： C07J43/003 , A61K31/58 , A61K45/06
摘要： The invention relates to AKR1C3 inhibitors and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular bleeding disorders and endometriosis.
摘要翻译： 本发明涉及AKR1C3抑制剂及其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是出血性疾病和子宫内膜异位症的药物的用途。
-
2.发明申请Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, processes for their preparation, pharmaceutical preparations comprising them and their use for preparing medicaments 有权Estra-1,3,5（10），16-四烯-3-甲酰胺衍生物，其制备方法，包含它们的药物制剂及其制备药物的用途公开(公告)号：US20140249119A1
公开(公告)日：2014-09-04
申请号：US14348645
申请日：2012-09-24
发明人： Ulrich Bothe , Naomi Barak , Matthias Busemann , Oliver Martin Fischer , Andrea Rotgeri , Isabella Gashaw , Ingo Hartung , Tobias Marquardt
CPC分类号： C07J43/003 , A61K31/58 , A61K45/06
摘要： The invention relates to AKR1C3 inhibitors and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular bleeding disorders and endometriosis.
摘要翻译： 本发明涉及AKR1C3抑制剂及其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是出血性疾病和子宫内膜异位症的药物的用途。
-
公开(公告)号：US09714266B2
公开(公告)日：2017-07-25
申请号：US14770444
申请日：2014-02-18
发明人： Ulrich Bothe , Matthias Busemann , Naomi Barak , Andrea Rotgeri , Oliver Martin Fischer , Tobias Marquardt
CPC分类号： C07J43/003 , A61K31/58 , A61K45/06
摘要： The invention relates to AKR1C3 inhibitors of formula (I) and to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of bleeding disorders and endometriosis.
-
公开(公告)号：US10023539B2
公开(公告)日：2018-07-17
申请号：US15534404
申请日：2015-12-08
发明人： Jeffrey Stuart Mowat , Timo Stellfeld , Carlo Stresemann , Roman Hillig , Silke Köhr , Detlef Stöckigt , Jörg Weiske , Thomas Brumby , Naomi Barak , Clara Christ , Antonius Ter Laak , Volker Badock , Rosemary Helen Crampton , Ian Stefanuti
IPC分类号： C07D231/06 , C07D401/12 , C07D403/12 , C07D413/12
摘要： The present invention relates to protein-lysine N-methyltransferase SMYD2 (SET and MYND domain-containing protein 2) inhibitors, in particular SMYD2-inhibitory substituted cyanoguanidine-pyrazolines of general formula (I) wherein R1, R2, R3, R4, R5, X and r have the meaning as described and defined herein, as well as to pharmaceutical compositions comprising compounds according to the invention and to their prophylactic and therapeutic use for hyper-proliferative disorders, in particular for cancer, respectively tumor disorders. The present invention furthermore relates to the use of SMYD2 inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, neurodegenerative disorders, inflammatory disorders, atherosclerotic disorders and the control of male fertility.
-
5.发明授权3-substituted estra-1,3,5(10),16-tetraene derivatives, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments 有权3-取代的雌-1,3,5（10），16-四烯衍生物，其制备方法，含有它们的药物制剂及其用于生产药物的用途公开(公告)号：US09512169B2
公开(公告)日：2016-12-06
申请号：US14414386
申请日：2013-07-05
发明人： Ulrich Bothe , Matthias Busemann , Oliver Martin Fischer , Naomi Barak , Andrea Rotgeri , Tobias Marquardt , Christian Stegmann
CPC分类号： C07J43/003 , A61K31/58
摘要： The invention relates to AKR1C3 inhibitors and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular bleeding disorders and endometriosis.
摘要翻译： 本发明涉及AKR1C3抑制剂及其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是出血性疾病和子宫内膜异位症的药物的用途。
-
6.发明申请3-SUBSTITUTED ESTRA-1,3,5(10),16-TETRAENE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING SAME, AND USE THEREOF FOR THE PRODUCTION OF MEDICAMENTS 有权3-取代的ESTRA-1,3,5（10），16-四烯衍生物，其生产方法，含有它们的药物制剂及其用于生产药物的用途公开(公告)号：US20150210734A1
公开(公告)日：2015-07-30
申请号：US14414386
申请日：2013-07-05
发明人： Ulrich Bothe , Matthias Busemann , Oliver Martin Fischer , Naomi Barak , Andrea Rotgeri , Tobias Marquardt , Christian Stegmann
CPC分类号： C07J43/003 , A61K31/58
摘要： The invention relates to AKR1C3 inhibitors and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular bleeding disorders and endometriosis.
摘要翻译： 本发明涉及AKR1C3抑制剂及其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是出血性疾病和子宫内膜异位症的药物的用途。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.025 秒)
