公开(公告)号：US20180141931A1

公开(公告)日：2018-05-24

申请号：US15847684

申请日：2017-12-19

申请人： Bayer Pharma Aktiengesellschaft

发明人： Eva Maria BECKER-PELSTER ,  Philipp BUCHGRABER ,  Anja BUCHMÜLLER ,  Karen ENGEL ,  Volker GEISS ,  Andreas GÖLLER ,  Herbert HIMMEL ,  Raimund KAST ,  Andreas KNORR ,  Dieter LANG ,  Gorden REDLICH ,  Carsten SCHMECK ,  Hanna TINEL ,  Frank WUNDER

IPC分类号： C07D401/14 ,  A61K45/06 ,  A61K31/541 ,  A61K31/5377 ,  C07D491/107 ,  C07D417/14 ,  C07D413/14 ,  A61K31/506

摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.

公开(公告)号：US20160318901A1

公开(公告)日：2016-11-03

申请号：US15106284

申请日：2014-12-16

申请人： Bayer Pharma Aktiengesellschaft

发明人： Eva Maria BECKER-PELSTER ,  Philipp BUCHGRABER ,  Anja BUCHMÜLLER ,  Karen ENGEL ,  Volker GEISS ,  Andreas GÖLLER ,  Herbert HIMMEL ,  Raimund KAST ,  Andreas KNORR ,  Dieter LANG ,  Gorden REDLICH ,  Carsten SCHMECK ,  Hanna TINEL ,  Frank WUNDER

IPC分类号： C07D401/14 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/541 ,  C07D413/14 ,  A61K31/506 ,  C07D491/107

CPC分类号： C07D401/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D413/14 ,  C07D417/14 ,  C07D491/107

摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.

摘要翻译： 本申请涉及新的取代的哌啶基四氢喹啉，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病性溃疡，特别是促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，周围循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。

公开(公告)号：US20160304492A1

公开(公告)日：2016-10-20

申请号：US15106286

申请日：2014-12-16

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Eva Maria BECKER-PELSTER ,  Philipp BUCHGRABER ,  Anja BUCHMÜLLER ,  Karen ENGEL ,  Andreas GÖLLER ,  Herbert HIMMEL ,  Raimund KAST ,  Joerg KELDENICH ,  Carsten SCHMECK ,  Hanna TINEL ,  Frank WUNDER

IPC分类号： C07D401/14 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/541 ,  C07D491/107 ,  A61K45/06 ,  A61K31/4545

CPC分类号： C07D401/14 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D401/06 ,  C07D403/14 ,  C07D413/14 ,  C07D491/107

摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.

摘要翻译： 本发明涉及新的取代的二哌啶基衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病性溃疡，特别是促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，外周循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。

公开(公告)号：US20160304491A1

公开(公告)日：2016-10-20

申请号：US15106283

申请日：2014-12-16

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Eva Maria BECKER-PELSTER ,  Philipp BUCHGRABER ,  Anja BUCHMÜLLER ,  Karen ENGEL ,  Volker GEISS ,  Andreas GÖLLER ,  Herbert HIMMEL ,  Raimund KAST ,  Andreas KNORR ,  Dieter LANG ,  Gorden REDLICH ,  Carsten SCHMECK ,  Hanna TINEL ,  Frank WUNDER

IPC分类号： C07D401/14 ,  A61K31/506 ,  A61K31/4725 ,  C07D495/10 ,  C07D491/107 ,  C07D413/14 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/541

CPC分类号： C07D401/14 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D413/14 ,  C07D491/107 ,  C07D495/10

摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.

摘要翻译： 本申请涉及新的取代的哌啶基四氢喹啉，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病性溃疡，特别是促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，外周循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。