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公开(公告)号：US20180141931A1
公开(公告)日：2018-05-24
申请号：US15847684
申请日：2017-12-19
发明人： Eva Maria BECKER-PELSTER , Philipp BUCHGRABER , Anja BUCHMÜLLER , Karen ENGEL , Volker GEISS , Andreas GÖLLER , Herbert HIMMEL , Raimund KAST , Andreas KNORR , Dieter LANG , Gorden REDLICH , Carsten SCHMECK , Hanna TINEL , Frank WUNDER
IPC分类号： C07D401/14 , A61K45/06 , A61K31/541 , A61K31/5377 , C07D491/107 , C07D417/14 , C07D413/14 , A61K31/506
摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
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公开(公告)号：US20160272637A1
公开(公告)日：2016-09-22
申请号：US15032212
申请日：2014-10-28
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRASSBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Henrik TELLER , Eloisa JIMENEZ NUNEZ , Hartmut SCHIROK , Jürgen KLAR
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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公开(公告)号：US20170283412A1
公开(公告)日：2017-10-05
申请号：US15513853
申请日：2015-09-22
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRAßBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Henrik TELLER , Eloisa JIMÉNEZ NÚNEZ , Hartmut SCHIROK , Jürgen KLAR , Mario LOBELL
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US20160244437A1
公开(公告)日：2016-08-25
申请号：US15024923
申请日：2014-09-24
发明人： Ulrike RÖHN , Manuel ELLERMANN , Julia STRASSBURGER , Astrid WENDT , Susanne RÖHRIG , Robert Alan WEBSTER , Martina Victoria SCHMIDT , Adrian TERSTEEGEN , Kristin BEYER , Martina SCHÄFER , Anja BUCHMÜLLER , Christoph GERDES , Michael SPERZEL , Steffen SANDMANN , Stefan HEITMEIER , Alexander HILLISCH , Jens ACKERSTAFF , Carsten TERJUNG
IPC分类号： C07D413/12 , C07D249/12 , C07D235/26 , C07D401/12 , C07D401/14 , C07D271/07 , C07D249/10 , C07D231/56 , C07D235/10 , C07D257/04 , C07D403/12
CPC分类号： C07D413/12 , C07D231/56 , C07D235/10 , C07D235/26 , C07D249/10 , C07D249/12 , C07D257/04 , C07D271/07 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The invention relates to substituted phenylalanine derivatives and to processes for preparation thereof, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and/or severe perioperative blood loss.
摘要翻译： 本发明涉及取代的苯丙氨酸衍生物及其制备方法及其用于生产用于治疗和/或预防特别是心血管疾病和/或严重围手术期失血的疾病的药物的用途。
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公开(公告)号：US20160237067A1
公开(公告)日：2016-08-18
申请号：US15024327
申请日：2014-09-24
发明人： Ulrike RÖHN , Manuel ELLERMANN , Julia STRASSBURGER , Astrid WENDT , Susanne RÖHRIG , Robert Alan WEBSTER , Martina Victoria SCHMIDT , Adrian TERSTEEGEN , Kristin BEYER , Martina SCHÄFER , Anja BUCHMÜLLER , Christoph GERDES , Michael SPERZEL , Steffen SANDMANN , Stefan HEITMEIER , Alexander HILLISCH , Jens ACKERSTAFF , Carsten TERJUNG
IPC分类号： C07D405/12 , C07D403/12 , C07D231/56 , C07D235/26 , C07D249/08 , C07D257/04 , C07D401/12
CPC分类号： C07D405/12 , C07D231/56 , C07D235/26 , C07D249/08 , C07D249/10 , C07D257/04 , C07D401/12 , C07D403/12
摘要： The invention relates to substituted phenylalanine derivatives and to processes for preparation thereof, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and/or severe perioperative blood loss.
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6.发明申请SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF AS FACTOR XIA/PLASMA 有权取代的碘吡啶衍生物及其作为因子XIA / PLASMA的用途公开(公告)号：US20160152613A1
公开(公告)日：2016-06-02
申请号：US14906771
申请日：2014-07-21
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRAßBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Anja BUCHMÜLLER , Christoph GERDES , Henrik TELLER , Martina SCHÄFER , Adrian TERSTEEGEN
IPC分类号： C07D471/04 , C07D215/227 , C07D413/12 , C07D401/12 , C07D221/04
CPC分类号： A61K31/438 , A61K31/437 , C07D215/227 , C07D221/04 , C07D401/12 , C07D413/12 , C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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公开(公告)号：US20160108027A1
公开(公告)日：2016-04-21
申请号：US14895625
申请日：2014-05-30
发明人： Swen ALLERHEILlGEN , Anja BUCHMÜLLER , Karen ENGEL , Christoph GERDES , Kersten Matthias GERICKE , Michael GERISCH , Stefan HEITMEIER , Alexander HILLlSCH , Tom KINZEL , Philip LIENAU , Bernd RIEDL , Susanne RÖHRIG , Martina Victoria SCHMIDT , Julia STRASSBURGER , Adrian TERSTEEGEN
IPC分类号： C07D413/14 , C07D487/04
CPC分类号： C07D413/14 , C07D413/12 , C07D487/04
摘要： The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.
摘要翻译： 本发明涉及取代的苯并恶唑及其制备方法及其制备药物用途，用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病。
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8.发明申请Substituted Oxopyridine Derivatives and Use Thereof in the Treatment of Cardiovascular Disorders 有权取代的氧吡啶衍生物及其用途治疗心血管疾病公开(公告)号：US20160052884A1
公开(公告)日：2016-02-25
申请号：US14780925
申请日：2014-03-27
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRAßBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Tom KINZEL , Henrik TELLER , Hartmut SCHIROK , Jürgen KLAR , Eloisa JIMENEZ NUNEZ
IPC分类号： C07D213/64 , C07D413/12 , C07D213/84 , C07D409/06 , C07D405/06 , C07D413/14 , C07D417/12 , C07D401/12 , C07D213/69
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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公开(公告)号：US20190284300A1
公开(公告)日：2019-09-19
申请号：US16292196
申请日：2019-03-04
发明人： Andreas WILMEN , Julia STRAßBURGER , Frank DITTMER , Michael STRERATH , Anja BUCHMÜLLER , Joanna GRUDZINSKA-GOEBEL , Ricarda FINNERN , Martina SCHÄFER , Christoph GERDES , Hannah JÖRIßEN , Asako ITAKURA , Philberta Y. LEUNG , Erik TUCKER
IPC分类号： C07K16/36
摘要： The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.
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公开(公告)号：US20180251447A1
公开(公告)日：2018-09-06
申请号：US15969222
申请日：2018-05-02
发明人： Marie-Pierre COLLIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D401/14 , A61K45/06 , A61K31/4439
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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