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公开(公告)号：US20200253961A1
公开(公告)日：2020-08-13
申请号：US16758802
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Hanna TINEL , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Klemens LUSTIG
IPC分类号： A61K31/496 , A61K45/06 , A61P9/12 , A61K31/4196 , C07D403/06 , C07D403/14 , C07D413/14 , A61K31/422 , A61K31/454 , A61K31/55 , A61K31/541 , C07D417/14 , C07D487/10
摘要： The present invention relates to novel amine substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20200338096A1
公开(公告)日：2020-10-29
申请号：US16758742
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Hana CERNECKA , Karoline DROEBNER , Hanna TINEL , Anja BUCHMUELLER , Thomas MONDRITZKI , Axel KRETSCHMER , Klemens LUSTIG , Robert FRICKE , Guillaume LEVILAIN , Ursula KRENZ , Norbert WITOWSKI
IPC分类号： A61K31/675 , A61K45/06 , C07F9/6558 , A61P13/12
摘要： The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190315720A1
公开(公告)日：2019-10-17
申请号：US16343150
申请日：2017-10-16
发明人： Chantal FUERSTNER , Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Elisabeth POOK , Heiko SCHIRMER , Carsten SCHMECK , Pierre WASNAIRE , Matthias Beat WITTWER
IPC分类号： C07D403/06 , C07D403/14 , A61P13/12
摘要： The present invention relates to novel 3-(hydroxyalkyl)-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and/or cardiovascular diseases.
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公开(公告)号：US20210253557A1
公开(公告)日：2021-08-19
申请号：US16758741
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Hanna TINEL , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Klemens LUSTIG , Nils GRIEBENOW
摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20200316045A1
公开(公告)日：2020-10-08
申请号：US16756623
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Hanna TINEL , Niels LINDNER , Heiko SCHIRMER
IPC分类号： A61K31/4439 , A61K45/06 , C07D401/14 , A61K31/496 , C07D403/14 , C07D417/14 , A61K31/541 , A61K31/5377 , C07D413/14 , C07D409/14 , A61K31/4188 , C07D487/10 , A61K31/4196 , C07D403/06 , C07D405/14 , A61K31/551
摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20200157073A1
公开(公告)日：2020-05-21
申请号：US16604157
申请日：2018-04-04
发明人： Hartmut BECK , Raimund KAST , Mark MEININGHAUS , Chantal FUERSTNER , Timo STELLFELD , Clemens-Jeremias VON BUEHLER , Lisa DIETZ , Michaela BAIRLEIN , Johanna ANLAHR , Hannah JOERISSEN , Peter HAUFF , Joerg MUELLER , Karoline DROEBNER , Jens NAGEL
IPC分类号： C07D401/04 , A61P11/00 , A61P1/16 , A61P13/12 , C07D215/50 , C07D413/04 , C07D417/04
摘要： The present application relates to novel substituted N-arylethyl-2-aminoquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.
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公开(公告)号：US20200299271A1
公开(公告)日：2020-09-24
申请号：US16880933
申请日：2020-05-21
发明人： Heiko SCHIRMER , Philipp RUBENBAUER , Hans-Christian MILITZER , Marie-Pierre COLLIN-KROEPELIN , Frank SUESSMEIER , Kersten GERICKE , Thomas NEUBAUER , Chantal FUERSTNER
IPC分类号： C07D403/06 , C07D249/12
摘要： The present application relates to a novel and improved process for preparing 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives of the formula (I) in which R1A and R1B are independently selected from the group consisting of hydrogen, fluorine, chlorine, methyl, monofluoromethyl, difluoromethyl, trifluoromethyl, ethyl, methoxy, difluoromethoxy and trifluoromethoxy, to novel precursors for preparation thereof, and to the preparation and use of the crystalline polymorph I of (5-(4-chlorophenyl)-2-({1-(3-chlorophenyl)-5-[(1S)-1-hydroxyethyl]-1H-1,2,4-triazol-3-yl}methyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one of the formula (I-A-1).
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公开(公告)号：US20200255402A1
公开(公告)日：2020-08-13
申请号：US16758345
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Heiko SCHIRMER , Hanna TINEL
IPC分类号： C07D401/14
摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20210179590A1
公开(公告)日：2021-06-17
申请号：US16758744
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Hanna TINEL , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Klemens LUSTIG
IPC分类号： C07D403/14 , C07D403/06 , C07D405/14 , C07D401/14 , C07D413/14 , A61P9/10 , A61K45/06
摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20200017473A1
公开(公告)日：2020-01-16
申请号：US16579341
申请日：2019-09-23
发明人： Marie-Pierre COLLIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMUELLER , Hanna TINEL , Karoline DROEBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D401/14 , A61P9/04 , A61P13/12 , A61P3/10 , A61P9/10 , A61K45/06 , A61K31/4439
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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