-
公开(公告)号：US20220153745A1
公开(公告)日：2022-05-19
申请号：US17516542
申请日：2021-11-01
发明人： Dirk BROHM , Melanie HEROULT , Marie-Pierre COLLIN , Walter HÜBSCH , Mario LOBELL , Klemens LUSTIG , Sylvia GRÜNEWALD , Ulf BÖMER , Verena VÖHRINGER
IPC分类号： C07D487/04 , C07D409/14 , C07D409/04 , A61P35/00 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/541
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —CH2—OR3, —CH2—NR4R5 or —C(=0)-NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group —CR8AR8B—OH, —CH2—NR9R10, —C(=0)—NR11R12 or —CH2—OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
-
2.发明申请公开(公告)号：US20220017540A1
公开(公告)日：2022-01-20
申请号：US17305927
申请日：2021-07-16
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Klemens LUSTIG , Karl COLLINS , Niels LINDNER , Janine NICOLAI , Moritz BECK-BROICHSITTER , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN
IPC分类号： C07D519/00 , A61P11/00
摘要： The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.
-
公开(公告)号：US20200338096A1
公开(公告)日：2020-10-29
申请号：US16758742
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Hana CERNECKA , Karoline DROEBNER , Hanna TINEL , Anja BUCHMUELLER , Thomas MONDRITZKI , Axel KRETSCHMER , Klemens LUSTIG , Robert FRICKE , Guillaume LEVILAIN , Ursula KRENZ , Norbert WITOWSKI
IPC分类号： A61K31/675 , A61K45/06 , C07F9/6558 , A61P13/12
摘要： The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US20210253557A1
公开(公告)日：2021-08-19
申请号：US16758741
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Hanna TINEL , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Klemens LUSTIG , Nils GRIEBENOW
摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US20200316045A1
公开(公告)日：2020-10-08
申请号：US16756623
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Hanna TINEL , Niels LINDNER , Heiko SCHIRMER
IPC分类号： A61K31/4439 , A61K45/06 , C07D401/14 , A61K31/496 , C07D403/14 , C07D417/14 , A61K31/541 , A61K31/5377 , C07D413/14 , C07D409/14 , A61K31/4188 , C07D487/10 , A61K31/4196 , C07D403/06 , C07D405/14 , A61K31/551
摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
![2-PHENYL-3-(PIPERAZINOMETHYL)IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS BLOCKERS OF TASK-1 AND TASK-2 CHANNELS, FOR THE TREATMENT OF SLEEP-RELATED BREATHING DISORDERS](/abs-image/US/2019/02/28/US20190062326A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190062326A1
公开(公告)日：2019-02-28
申请号：US15756867
申请日：2016-12-07
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Heinrich MEIER , Klemens LUSTIG , Johanna MOSIG , Luisella TOSCHI , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN
IPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , A61P11/16
摘要： The present application relates to novel 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.
-
公开(公告)号：US20170320854A1
公开(公告)日：2017-11-09
申请号：US15581064
申请日：2017-04-28
发明人： Marie-Pierre COLLIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D401/14 , A61K45/06 , A61K31/4439
CPC分类号： C07D401/14 , A61K31/4439 , A61K45/06
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US20160122325A1
公开(公告)日：2016-05-05
申请号：US14930157
申请日：2015-11-02
发明人： Carsten SCHMECK , Michael GERISCH , Nils GRIEBENOW , Peter KOLKHOF , Florian KOLLING , Anna ENGELEN , Axel KRETSCHMER , Dieter LANG , Klemens LUSTIG , Thomas MONDRITZKI , Elisabeth POOK , Hartmut BECK , Frank SÜßMEIER , Sonja VOLLMER , Pierre WASNAIRE
IPC分类号： C07D403/06 , A61K45/06 , A61K31/4196
CPC分类号： C07D249/12 , A61K31/4196 , A61K45/06 , C07D403/06
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
摘要翻译： 本发明涉及新的5-（羟基烷基）-1-苯基-1,2,4-三唑衍生物，制备这些化合物的方法，含有这些化合物的药物组合物，以及这些化合物或组合物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管和肾脏疾病。
-
公开(公告)号：US20200253961A1
公开(公告)日：2020-08-13
申请号：US16758802
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Hanna TINEL , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Klemens LUSTIG
IPC分类号： A61K31/496 , A61K45/06 , A61P9/12 , A61K31/4196 , C07D403/06 , C07D403/14 , C07D413/14 , A61K31/422 , A61K31/454 , A61K31/55 , A61K31/541 , C07D417/14 , C07D487/10
摘要： The present invention relates to novel amine substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US20190161453A1
公开(公告)日：2019-05-30
申请号：US16098227
申请日：2017-05-02
发明人： Carsten SCHMECK , Anna ENGELEN , Peter KOLKHOF , Klemens LUSTIG , Elisabeth POOK , Pierre WASNAIRE
IPC分类号： C07D249/12 , A61P9/00
摘要： The present invention relates to novel Oxoalkyl-substituted 1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
-
-
-
-
-
-
-
-
-
搜索结果
28 条记录 (耗时 0.026 秒)
