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公开(公告)号：US20210317128A1
公开(公告)日：2021-10-14
申请号：US16759262
申请日：2018-10-18
发明人： Marcus KOPPITZ , Holger SIEBENEICHER , Nico BRÄUER , Elisabeth POOK , Andrea ROTGERI , Roland NEUHAUS , Oliver Martin FISCHER , Jens NAGEL , Adam James DAVENPORT , James Lindsay CARR , Robert James TOWNSEND , Nina CONNELLY URSINYOVA , Shelley Anne PARROTT
IPC分类号： C07D487/14
摘要： The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20200338096A1
公开(公告)日：2020-10-29
申请号：US16758742
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Hana CERNECKA , Karoline DROEBNER , Hanna TINEL , Anja BUCHMUELLER , Thomas MONDRITZKI , Axel KRETSCHMER , Klemens LUSTIG , Robert FRICKE , Guillaume LEVILAIN , Ursula KRENZ , Norbert WITOWSKI
IPC分类号： A61K31/675 , A61K45/06 , C07F9/6558 , A61P13/12
摘要： The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190315720A1
公开(公告)日：2019-10-17
申请号：US16343150
申请日：2017-10-16
发明人： Chantal FUERSTNER , Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Elisabeth POOK , Heiko SCHIRMER , Carsten SCHMECK , Pierre WASNAIRE , Matthias Beat WITTWER
IPC分类号： C07D403/06 , C07D403/14 , A61P13/12
摘要： The present invention relates to novel 3-(hydroxyalkyl)-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and/or cardiovascular diseases.
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公开(公告)号：US20200255402A1
公开(公告)日：2020-08-13
申请号：US16758345
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Heiko SCHIRMER , Hanna TINEL
IPC分类号： C07D401/14
摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190161454A1
公开(公告)日：2019-05-30
申请号：US16098266
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D249/12 , A61K45/06 , A61K31/4196 , A61P9/00 , A61P13/12
摘要： The present invention relates to novel 5-(carboxamide)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190144423A1
公开(公告)日：2019-05-16
申请号：US16098308
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D401/14 , A61P13/12 , A61P9/04 , A61P9/10 , A61P3/10
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190142804A1
公开(公告)日：2019-05-16
申请号：US16098255
申请日：2017-05-02
发明人： Thomas NEUBAUER , Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER
IPC分类号： A61K31/4196 , C07D401/14 , C07D403/06 , C07D405/14 , A61K45/06 , A61K31/4439 , A61P9/10 , A61P13/12
CPC分类号： A61K31/4196 , A61K31/4439 , A61K45/06 , A61P9/10 , A61P13/12 , C07D249/12 , C07D401/14 , C07D403/06 , C07D405/14
摘要： The present invention relates to novel 5-(fluoroalkyl)-1-aryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190119251A1
公开(公告)日：2019-04-25
申请号：US16098262
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA , Axel KRETSCHMER
IPC分类号： C07D401/14 , A61K45/06 , A61K31/4439 , C07D403/14 , A61K31/497 , A61K31/506 , C07D403/06 , A61K31/4196
摘要： The present invention relates to novel 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20220324865A1
公开(公告)日：2022-10-13
申请号：US17055190
申请日：2019-05-10
发明人： Steffen MUELLER , Rudolf SCHOHE-LOOP , Nuria ORTEGA HERNANDEZ , Frank SUESSMEIER , Eloisa JIMENEZ NUNEZ , Thomas BRUMBY , Niels LINDNER , Christoph GERDES , Elisabeth POOK , Anja BUCHMUELLER , Fabienne Zdenka GAUGAZ , Dieter LANG , Stefanie ZIMMERMANN , Alexander Helmut Michael EHRMANN , Michael GERISCH , Lutz LEHMANN , Andreas TIMMERMANN , Martina SCHAEFER , Georg SCHMIDT , Karl-Heinz SCHLEMMER , Markus FOLLMANN , Elisabeth KERSTEN , Vivian WANG , Xiang GAO , Yafeng WANG
IPC分类号： C07D487/04 , A61P7/02
摘要： The invention relates to substituted dihydropyrazolo pyrazine carboxamide derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.
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公开(公告)号：US20210253557A1
公开(公告)日：2021-08-19
申请号：US16758741
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Hanna TINEL , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Klemens LUSTIG , Nils GRIEBENOW
摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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