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公开(公告)号：US11040035B2
公开(公告)日：2021-06-22
申请号：US16303539
申请日：2017-05-23
发明人： Norbert Schmees , Ilona Gutcher , Horst Irlbacher , Benjamin Bader , Na Zhao , Michael Platten , Ulrike Röhn , Ludwig Zorn , Lars Röse , Detlef Stöckigt
IPC分类号： C07D237/14 , C07D237/20 , C07D401/10 , C07D405/12 , A61K31/501 , A61P35/00 , A61K31/50 , A61K45/06 , C07D237/24 , C07D403/12
摘要： The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11655297B2
公开(公告)日：2023-05-23
申请号：US16766224
申请日：2018-11-28
发明人： Lars Röse , Uwe Gritzan , Julia Hütter , Spencer Liang , Andrew Pow , John Hunter , Ofer Levy , Ilan Vaknin
IPC分类号： C07K16/28 , A61P35/00 , A61K31/337 , A61K31/713
CPC分类号： C07K16/2818 , A61K31/337 , A61K31/713 , A61P35/00
摘要： The present invention relates to a novel pharmaceutical combination comprising an ILDR2 antagonist according to any of the aforementioned claims, plus one or more other therapeutically active compounds, and to novel specific ILDR2 antagonists.
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公开(公告)号：US11459312B2
公开(公告)日：2022-10-04
申请号：US16765709
申请日：2018-11-16
发明人： Ludwig Zorn , Ulrike Röhn , Ilona Gutcher , Lars Röse , Benjamin Bader , Christina Kober , Rafael Carretero , Detlef Stöckigt , Michael Platten
IPC分类号： C07D403/04 , C07D237/14 , C07D409/12 , C07D409/14 , C07D419/14 , A61P35/00 , C07D417/14 , A61K45/06
摘要： Disclosed are compounds of general formula (I): wherein R1, R2, A, X, Y and Z are as defined herein, methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and combinations comprising the compounds and the use of the compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11795164B2
公开(公告)日：2023-10-24
申请号：US17819602
申请日：2022-08-12
发明人： Ilona Gutcher , Norbert Schmees , Lars Röse , Benjamin Bader , Christina Kober , Rafael Carretero , Detlef Stöckigt , Horst Irlbacher , Michael Platten
IPC分类号： C07D417/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , A61P35/00
CPC分类号： C07D417/04 , A61P35/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04
摘要： The present invention covers 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compounds of general formula (1):
in which X, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.-
5.发明申请INTRAUTERINE APPLICATION OF 18-METHYL-15SS,16SS-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONE SYSTEMS, INTRAUTERINE SYSTEMS CONTAINING 18-METHYL-15SS,16SS-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONE, AS WELL AS THE USE THEREOF IN CONTRACEPTION AND GYNAECOLOGICAL THERAPY 审中-公开18-甲基-15SS，16SS-甲基-19-异-20-螺环-4-EN-3-ONE系统的内含子应用，含有18-甲基-15SS，16SS-甲基-19-非 - 20-螺旋体的内含子系统 -4-EN-3-ONE，以及其在合同和妇科治疗中的应用公开(公告)号：US20150065472A1
公开(公告)日：2015-03-05
申请号：US14396736
申请日：2013-04-19
发明人： Norbert Schmees , Lars Röse , Tuula Valo , Katja Prelle , Reinhard Nubbemeyer , Henriikka Korolainen , Harri Jukarainen
CPC分类号： A61K31/58 , A61K9/0039
摘要： The present invention describes intrauterine use of 18-methyl-15β,16β-methylene-19-nor-20-spirox-4-en-3-ones of the general formula (1) in contraception and gynaecological treatment, and an intrauterine system comprising compounds of formula 1.
摘要翻译： 本发明描述了在避孕和妇科治疗中宫颈内使用通式（1）的18-甲基-15β，16β-亚甲基-19-去甲螺环-4-烯-3-酮和子宫内 系统包含式1的化合物。
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公开(公告)号：US11591311B2
公开(公告)日：2023-02-28
申请号：US16765806
申请日：2018-11-16
发明人： Ilona Gutcher , Ulrike Röhn , Ludwig Zorn , Lars Röse , Benjamin Bader , Christina Kober , Rafael Carretero , Detlef Stöckigt , Michael Platten
IPC分类号： C07D401/04 , A61P35/04 , C07D403/04 , C07D405/14 , C07D409/14 , A61K45/06
摘要： The present invention covers 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyri-dazine-4-carboxamide compounds of general formula (I): in which R1, R2, R4, R5, R6, X, Y and Z are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11524944B2
公开(公告)日：2022-12-13
申请号：US16765780
申请日：2018-11-16
发明人： Julien Lefranc , Norbert Schmees , Ulrike Röhn , Ludwig Zorn , Judith Günther , Ilona Gutcher , Lars Röse , Benjamin Bader , Detlef Stöckigt , Michael Platten
IPC分类号： C07D239/28 , A61P35/04 , C07D405/12 , A61K45/06
摘要： The present invention covers 2-phenylpyrimidine-4-carboxamide compounds of general formula (I): (I) 5 in which X, Y, Z, R1, R2, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11304946B2
公开(公告)日：2022-04-19
申请号：US16765778
申请日：2018-11-16
发明人： Julien Lefranc , Norbert Schmees , Ulrike Röhn , Ludwig Zorn , Judith Günther , Ilona Gutcher , Lars Röse , Benjamin Bader , Detlef Stöckigt , Michael Platten
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , A61K31/506
摘要： The present invention covers 2-hetarylpyrimidine-4-carboxamide compounds of general formula (I): in which X, Y, Z, R1, R2 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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9.发明申请APPLICATION OF 18-METHYL-15SS,16SS-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONE SYSTEMS IN THE TREATMENT OF MENORRHAGIA, AS WELL AS INTRAUTERINE SYSTEMS CONTAINING 18-METHYL-15SS,16SS-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONE FOR TREATING UTERINE BLEEDING DISORDERS 审中-公开18-METHLL-15SS，16SS-甲基-19-异20-螺旋-4-烯-3-ONE系统在治疗子宫颈癌中的应用，作为含有18-甲基-15SS，16SS-甲基 - 19-NOR-20-SPIROX-4-EN-3-ONE用于治疗子宫脱垂症公开(公告)号：US20150119372A1
公开(公告)日：2015-04-30
申请号：US14396742
申请日：2013-04-19
发明人： Norbert Schmees , Lars Röse , Tuula Valo , Katja Prelle , Reinhard Nubbemeyer , Henriikka Korolainen , Harri Jukarainen
IPC分类号： A61K31/58
CPC分类号： A61K31/58 , A61K9/0039
摘要： The present invention describes intrauterine use of 18-methyl-15β,16β-methylene-19-nor-20-spirox-4-en-3-ones of the general formula (1) wherein R6 and R7 are hydrogen or a methylene group, in the treatment of menorrhagia, of uterine haemorrhages in general, and an intrauterine system for said use, comprising a compound of formula 1.
摘要翻译： 本发明描述了通式（1）的18-甲基-15β，16β-亚甲基-19-去甲代螺环-4-烯-3-酮的宫内使用，其中R 6和R 7是氢或亚甲基 组，治疗月经过多，子宫出血一般，以及所述用途的子宫内系统，其包含式1的化合物。
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