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公开(公告)号：US11459312B2
公开(公告)日：2022-10-04
申请号：US16765709
申请日：2018-11-16
发明人： Ludwig Zorn , Ulrike Röhn , Ilona Gutcher , Lars Röse , Benjamin Bader , Christina Kober , Rafael Carretero , Detlef Stöckigt , Michael Platten
IPC分类号： C07D403/04 , C07D237/14 , C07D409/12 , C07D409/14 , C07D419/14 , A61P35/00 , C07D417/14 , A61K45/06
摘要： Disclosed are compounds of general formula (I): wherein R1, R2, A, X, Y and Z are as defined herein, methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and combinations comprising the compounds and the use of the compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11591311B2
公开(公告)日：2023-02-28
申请号：US16765806
申请日：2018-11-16
发明人： Ilona Gutcher , Ulrike Röhn , Ludwig Zorn , Lars Röse , Benjamin Bader , Christina Kober , Rafael Carretero , Detlef Stöckigt , Michael Platten
IPC分类号： C07D401/04 , A61P35/04 , C07D403/04 , C07D405/14 , C07D409/14 , A61K45/06
摘要： The present invention covers 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyri-dazine-4-carboxamide compounds of general formula (I): in which R1, R2, R4, R5, R6, X, Y and Z are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11524944B2
公开(公告)日：2022-12-13
申请号：US16765780
申请日：2018-11-16
发明人： Julien Lefranc , Norbert Schmees , Ulrike Röhn , Ludwig Zorn , Judith Günther , Ilona Gutcher , Lars Röse , Benjamin Bader , Detlef Stöckigt , Michael Platten
IPC分类号： C07D239/28 , A61P35/04 , C07D405/12 , A61K45/06
摘要： The present invention covers 2-phenylpyrimidine-4-carboxamide compounds of general formula (I): (I) 5 in which X, Y, Z, R1, R2, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11304946B2
公开(公告)日：2022-04-19
申请号：US16765778
申请日：2018-11-16
发明人： Julien Lefranc , Norbert Schmees , Ulrike Röhn , Ludwig Zorn , Judith Günther , Ilona Gutcher , Lars Röse , Benjamin Bader , Detlef Stöckigt , Michael Platten
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , A61K31/506
摘要： The present invention covers 2-hetarylpyrimidine-4-carboxamide compounds of general formula (I): in which X, Y, Z, R1, R2 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11040035B2
公开(公告)日：2021-06-22
申请号：US16303539
申请日：2017-05-23
发明人： Norbert Schmees , Ilona Gutcher , Horst Irlbacher , Benjamin Bader , Na Zhao , Michael Platten , Ulrike Röhn , Ludwig Zorn , Lars Röse , Detlef Stöckigt
IPC分类号： C07D237/14 , C07D237/20 , C07D401/10 , C07D405/12 , A61K31/501 , A61P35/00 , A61K31/50 , A61K45/06 , C07D237/24 , C07D403/12
摘要： The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11161825B2
公开(公告)日：2021-11-02
申请号：US16638683
申请日：2018-08-09
发明人： Jörg Weiske , Carlo Stresemann , Stefan Nikolaus Gradl , Ulrike Röhn , Clara Christ , Holger Steuber , Manfred Husemann , Norbert Schmees , Kai Thede , Stephan Siegel , Antonius Ter Laak
IPC分类号： C07D243/12 , C07D401/06 , C07D403/06 , C07D409/06 , C07D413/06
摘要： The present invention covers 4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamide compounds of general formula (I): in which R1, R2a, R2b, R2c, R3a, R3b, R4a, R4b, R5 and X are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US09655887B2
公开(公告)日：2017-05-23
申请号：US14893508
申请日：2014-05-16
发明人： Bernhard Lindenthal , Nico Bräuer , Peter Serno , Andrea Rotgeri , Ulrike Fuhrmann , Bernd Buchmann , Anne Mengel , Ulrike Röhn , Antonius Ter Laak
IPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/196 , A61K31/405 , A61K31/5415 , A61K31/18 , A61K31/192 , A61K31/365 , A61K31/407 , A61K31/42 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/542 , A61K31/635
CPC分类号： A61K31/454 , A61K31/18 , A61K31/192 , A61K31/196 , A61K31/365 , A61K31/405 , A61K31/407 , A61K31/416 , A61K31/42 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/5415 , A61K31/542 , A61K31/635 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition for non-hormonal, on-demand contraception and to processes for preparing this pharmaceutical composition. The latter comprises 2H-indazole as novel EP2 receptor antagonists in combination with COX inhibitors. The invention furthermore provides a method for non-hormonal female-controlled on-demand contraception where a pharmaceutical composition comprising EP2 receptor antagonists in combination with COX inhibitors is taken on demand prior to expected sexual intercourse.
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