公开(公告)号：US10023841B2

公开(公告)日：2018-07-17

申请号：US14719968

申请日：2015-05-22

Applicant: Baylor Research Institute

Inventor： Anna Karolina Palucka ,  Jacques F Banchereau ,  Lee Roberts

IPC: A61K39/00 ,  A61K35/15 ,  C12N5/0784 ,  A61K45/06 ,  A61K38/20 ,  A61K31/337 ,  A61K31/675 ,  A61K31/704

Abstract: Disclosed are compositions and methods for treatment of breast cancer. Disclosed methods and compositions include dendritic cells loaded with cyclin B1 and WT-1 peptide antigens for immunotherapy. These dendritic cell vaccines are administered alone or in combination with other cancer therapies to improve outcomes. Disclosed methods also involve the use of therapeutic agents, such as anakinra, that block the IL-1 inflammation pathway. These agents are used in combination with chemotherapy and/or immunotherapy in treating breast cancer.

公开(公告)号：US20130122049A1

公开(公告)日：2013-05-16

申请号：US13740984

申请日：2013-01-14

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Anna Karolina Palucka ,  Jacques F. Banchereau

IPC: A61K35/28

CPC classification number: A61K35/28 ,  A61K39/0011 ,  A61K2039/5152 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/6043

Abstract: The present invention includes compositions and methods for the isolation, purification and preparation of immunogenic antigens for the production of customized cancer vaccines that include dendritic cells that are contacted with an antigen that includes heat-shocked cancer cells.

Abstract translation: 本发明包括用于分离，纯化和制备用于生产定制的癌症疫苗的免疫原性抗原的组合物和方法，其包括与包含热休克癌细胞的抗原接触的树突状细胞。

公开(公告)号：US20150368612A1

公开(公告)日：2015-12-24

申请号：US14719968

申请日：2015-05-22

Applicant: Baylor Research Institute

Inventor： Anna Karolina Palucka ,  Jacques F. Banchereau ,  Lee Roberts

IPC: C12N5/0784 ,  A61N5/10 ,  A61K38/17 ,  A61K39/00 ,  A61K45/06

CPC classification number: C12N5/0639 ,  A61K31/337 ,  A61K31/675 ,  A61K31/704 ,  A61K35/15 ,  A61K38/2006 ,  A61K39/0011 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/545 ,  A61K2039/6006 ,  C12N2501/22 ,  C12N2501/2304 ,  A61K2300/00

Abstract: Disclosed are compositions and methods for treatment of breast cancer. Disclosed methods and compositions include dendritic cells loaded with cyclin B1 and WT-1 peptide antigens for immunotherapy. These dendritic cell vaccines are administered alone or in combination with other cancer therapies to improve outcomes. Disclosed methods also involve the use of therapeutic agents, such as anakinra, that block the IL-1 inflammation pathway. These agents are used in combination with chemotherapy and/or immunotherapy in treating breast cancer.

Abstract translation: 公开了用于治疗乳腺癌的组合物和方法。 公开的方法和组合物包括负载有用于免疫治疗的细胞周期蛋白B1和WT-1肽抗原的树突状细胞。 这些树突细胞疫苗单独施用或与其他癌症疗法组合施用以改善结果。 所公开的方法还涉及使用阻断IL-1炎症途径的治疗剂，例如阿那白拉。 这些药剂与化疗和/或免疫治疗联合用于治疗乳腺癌。