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公开(公告)号：US20240033340A1
公开(公告)日：2024-02-01
申请号：US18329696
申请日：2023-06-06
发明人： SangKon OH , Sandra ZURAWSKI , Gerard ZURAWSKI
IPC分类号： A61K39/12 , A61K39/395 , C07K16/28 , C07K14/005 , C12N7/00
CPC分类号： A61K39/12 , A61K39/395 , A61K39/39541 , C07K16/2878 , A61K39/3955 , C07K14/005 , C12N7/00 , C12N2710/20034 , A61K2039/505
摘要： Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers.
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公开(公告)号：US20230183366A1
公开(公告)日：2023-06-15
申请号：US17998611
申请日：2021-05-11
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCH MÉDICALE) , UNIVERSITE PARIS EST CRETEIL VAL DE MARNE , BAYLOR RESEARCH INSTITUTE , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
发明人： Yves LEVY , Sandra ZURAWSKI , Gérard ZURAWSKI
CPC分类号： C07K16/2878 , A61P35/00 , C07K2317/565
摘要： The disclosure relates to the field of OX40 activating proteins. More specifically, it is disclosed herein recombinant proteins with OX40 agonist antibodies or their antigen-binding fragments fused or linked to OX40 ligand. Also disclosed is the advantageous use of such OX40 activating proteins, in particular for inducing immune responses directed to delivered antigens such as viral or cancer antigens, and/or for treating cancer.
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公开(公告)号：US20220226448A1
公开(公告)日：2022-07-21
申请号：US17595588
申请日：2020-05-22
发明人： Botond Z. IGYÁRTÓ , Qingtai SU
摘要： Methods and compositions using artificial antigen presenting cells in immunotherapy. The artificial antigen presenting cells comprise substrate particles bound to endogenous MHC-peptide complexes obtained from one or more cells. Methods include administering the artificial antigen presenting cells to a patient to activate antigen-specific T cells.
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公开(公告)号：US20220175920A1
公开(公告)日：2022-06-09
申请号：US17598582
申请日：2020-03-26
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Paris est Cretéil Val de Marne , Baylor Research Institute , Assistance Publique-Hôpitaux de Paris (APHP)
发明人： Yves LEVY , Valentina CEGLIA , Sandra ZURAWSKI , Gerard ZURAWSKI
IPC分类号： A61K39/395 , A61K39/385 , C07K14/705 , C07K16/28 , A61P31/18
摘要： The disclosure relates to the field of CD40 activating proteins. More specifically, it is disclosed herein recombinant proteins with CD40 agonist antibodies or their antigen-binding fragments fused or linked to CD40 ligand. Also disclosed is the advantageous use of such CD40 activating proteins, in particular for inducing immune responses directed to delivered antigens such as viral or cancer antigens.
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公开(公告)号：US20220152192A1
公开(公告)日：2022-05-19
申请号：US17454108
申请日：2021-11-09
发明人： SangKon OH , Dapeng LI
IPC分类号： A61K39/145 , A61K47/68 , A61K51/10 , C07K16/28 , C07K14/005 , C07K14/195 , C07K14/37 , C07K14/405 , C07K14/435 , C12N5/0784 , C12N7/00
摘要： The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells.
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公开(公告)号：US11267895B2
公开(公告)日：2022-03-08
申请号：US16946302
申请日：2020-06-15
IPC分类号： C07K16/28 , C07K14/005 , A61K39/00
摘要： The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccine and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
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公开(公告)号：US20220054609A1
公开(公告)日：2022-02-24
申请号：US17447607
申请日：2021-09-14
发明人： SangKon OH , Gerard ZURAWSKI
摘要： Methods and compositions for treating multiple sclerosis using dendritic cell anti-ASGPR antibodies fused to myelin basic protein or myelin oligodendrocyte glycoprotein are provided.
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公开(公告)号：US11173202B2
公开(公告)日：2021-11-16
申请号：US16372832
申请日：2019-04-02
发明人： SangKon Oh , Dapeng Li
IPC分类号： A61K39/145 , A61K47/68 , A61K51/10 , C07K16/28 , C07K14/005 , C07K14/195 , C07K14/37 , C07K14/405 , C07K14/435 , C12N5/0784 , C12N7/00 , A61K39/00
摘要： The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells.
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公开(公告)号：US20210145784A1
公开(公告)日：2021-05-20
申请号：US16911195
申请日：2020-06-24
发明人： Charles R. ROE
IPC分类号： A61K31/225 , A23L33/10 , A23L33/12 , A23L33/175 , A23K20/174 , A23K20/158 , A23K50/10 , A23K50/75 , A23K50/80 , A61K31/202 , A61K31/19 , A61K31/22 , A23L2/52 , A61K9/00 , A61K38/47 , A23L33/115 , A23L33/16
摘要： A method for treating glycogen storage disease by administering an effective amount of a composition that includes ketogenic odd carbon fatty acids that ameliorate the symptoms of these diseases.
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公开(公告)号：US20210139992A1
公开(公告)日：2021-05-13
申请号：US16492524
申请日：2018-03-09
发明人： Ajay GOEL , Daisuke IZUMI
IPC分类号： C12Q1/6886
摘要： Dysregulated expression of microRNAs (miRNAs) has emerged as a hallmark feature in human cancers. Aspects of the disclosure relate to methods for selecting optimal therapy for a patient from several alternative treatment options. A major clinical challenge in cancer treatment is to identify the subset of patients who will benefit from a therapeutic regimen, both in metastatic and adjuvant settings. The number of anti-cancer drugs and multi-drug combinations has increased substantially in the past decade, however, treatments continue to be applied empirically using a trial-and-error approach. Here methods and compositions are provided to determine the optimal treatment option for gastric cancer patients.
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