公开(公告)号：US20180030545A1

公开(公告)日：2018-02-01

申请号：US15672778

申请日：2017-08-09

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Ajay Goel ,  Yuji Toiyama ,  C. Richard Boland ,  Yoshinaga Okugawa

IPC: C12Q1/68 ,  A61B1/31 ,  A61B10/04 ,  A61B10/00

CPC classification number: C12Q1/6886 ,  A61B1/31 ,  A61B10/0038 ,  A61B10/0051 ,  A61B10/007 ,  A61B10/04 ,  C12Q2600/154

Abstract: Embodiments provide methods and compositions related to detecting neoplasia in ulcerative colitis patients by detection and analysis of the methylation state of miR-1, -9, -124, miR-137 and/or miR-34b/c in samples from UC patients.

公开(公告)号：US10190174B2

公开(公告)日：2019-01-29

申请号：US15672778

申请日：2017-08-09

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Ajay Goel ,  Yuji Toiyama ,  C. Richard Boland ,  Yoshinaga Okugawa

IPC: C12Q1/68 ,  C12Q1/6886 ,  A61B1/31 ,  A61B10/00 ,  A61B10/04

Abstract: Embodiments provide methods and compositions related to detecting neoplasia in ulcerative colitis patients by detection and analysis of the methylation state of miR-1, -9, -124, miR-137 and/or miR-34b/c in samples from UC patients.

公开(公告)号：US09758835B2

公开(公告)日：2017-09-12

申请号：US14777414

申请日：2014-03-13

Applicant: Baylor Research Institute

Inventor： Ajay Goel ,  Yuji Toiyama ,  C. Richard Boland ,  Yoshinaga Okugawa

IPC: C12Q1/68 ,  A61B1/31 ,  A61B10/00 ,  A61B10/04

CPC classification number: C12Q1/6886 ,  A61B1/31 ,  A61B10/0038 ,  A61B10/0051 ,  A61B10/007 ,  A61B10/04 ,  C12Q2600/154

Abstract: Embodiments provide methods and compositions related to detecting neoplasia in ulcerative colitis patients by detection and analysis of the methylation state of miR-1, -9, -124, miR-137 and/or miR-34b/c in samples from UC patients.

公开(公告)号：US20160115548A1

公开(公告)日：2016-04-28

申请号：US14777414

申请日：2014-03-13

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Ajay Goel ,  Yuji Toiyama ,  C. Richard Boland ,  Yoshinaga Okugawa

IPC: C12Q1/68 ,  A61B10/04 ,  A61B10/00 ,  A61B1/31

CPC classification number: C12Q1/6886 ,  A61B1/31 ,  A61B10/0038 ,  A61B10/0051 ,  A61B10/007 ,  A61B10/04 ,  C12Q2600/154

Abstract: Embodiments provide methods and compositions related to detecting neoplasia in ulcerative colitis patients by detection and analysis of the methylation state of miR-1, -9, -124, miR-137 and/or miR-34b/c in samples from UC patients.

Abstract translation: 实施例提供了通过检测和分析来自UC患者的样品中miR-1，-9，-124，miR-137和/或miR-34b / c的甲基化状态来检测溃疡性结肠炎患者的瘤形成的方法和组合物。