公开(公告)号：US20230131025A1

公开(公告)日：2023-04-27

申请号：US17799234

申请日：2021-02-08

Applicant: Betta Pharmaceuticals Co., Ltd.

Inventor： Xiangyong LIU ,  Changyong QIU ,  Mengqiang LIU ,  Xiaodong SONG ,  Qichao SHEN ,  Guolong DU ,  Haitong SHENG ,  Lieming DING ,  Jiabing WANG

IPC: C07D401/12 ,  C07D215/38 ,  A61P35/00 ,  C07D401/14 ,  C07D417/14

Abstract: The present invention relates to a compound of formula (I), a method for using the compound as an EGFR inhibitor, and a pharmaceutical composition comprising the compound. The compound can be used for treatment, prevention or alleviation of diseases or disorders such as cancer or infection.

公开(公告)号：US20220402948A1

公开(公告)日：2022-12-22

申请号：US17763633

申请日：2020-09-25

Applicant: BETTA PHARMACEUTICALS CO., LTD.

Inventor： Xiangyong LIU ,  Changyong QIU ,  Haitong SHENG ,  Mengqiang LIU ,  Qichao SHEN ,  Guolong DU ,  Xiaodong SONG ,  Lieming DING ,  Jiabing WANG

IPC: C07F9/53

Abstract: The present invention relates to the compounds of Formula I, methods of using these compounds as EGFR inhibitors, and pharmaceutical compositions comprising compounds thereof. The compounds are used for treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US20220227796A1

公开(公告)日：2022-07-21

申请号：US17439324

申请日：2020-03-31

Applicant: Betta Pharmaceuticals Co., Ltd.

Inventor： Xiangyong LIU ,  Changyong QIU ,  Qichao SHEN ,  Mengqiang LIU ,  Haitong SHENG ,  Guolong DU ,  Jiabing WANG ,  Lieming DING

IPC: C07F9/6512 ,  C07F9/6561 ,  A61P35/00

Abstract: The present invention relates to compounds of Formula I, methods of using the compounds as EGFR inhibitors, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US20240336594A1

公开(公告)日：2024-10-10

申请号：US18576708

申请日：2022-06-24

Applicant: BETTA PHARMACEUTICALS CO., LTD

Inventor： Bang FU ,  Yinlong LI ,  Wei REN ,  Qichao SHEN ,  Guolong DU ,  Xiaojun ZHOU ,  Yun SUN ,  Yuzhen ZHOU ,  Xiao SUN ,  Weidong CAI ,  Xiangyong LIU ,  Lieming DING ,  Jiabing WANG

IPC: C07D401/14 ,  A61K31/167 ,  A61K31/18 ,  A61K31/423 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  A61K31/538 ,  C07C237/40 ,  C07C311/32 ,  C07C317/32 ,  C07C323/33 ,  C07D205/12 ,  C07D213/56 ,  C07D263/56 ,  C07D265/36 ,  C07D401/04 ,  C07D401/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/048 ,  C07D491/107

CPC classification number: C07D401/14 ,  A61K31/167 ,  A61K31/18 ,  A61K31/423 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  A61K31/538 ,  C07C237/40 ,  C07C311/32 ,  C07C317/32 ,  C07C323/33 ,  C07D205/12 ,  C07D213/56 ,  C07D263/56 ,  C07D265/36 ,  C07D401/04 ,  C07D401/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/048 ,  C07D491/107

Abstract: A compound of formula I and a use thereof as an MALT1 inhibitor, and a pharmaceutical composition containing the compound. The compound can be used to treat diseases or disorders such as cancer.

公开(公告)号：US20230133169A1

公开(公告)日：2023-05-04

申请号：US17768807

申请日：2020-10-13

Applicant: BETTA PHARMACEUTICALS CO., LTD

Inventor： Xiangyong LIU ,  Changyong QIU ,  Guolong DU ,  Qichao SHEN ,  Mengqiang LIU ,  Haitong SHENG ,  Lieming DING ,  Jiabing WANG

IPC: C07D239/48 ,  C07D403/10

Abstract: Provided are the compounds of Formula I, a method for using these compounds as an EGFR inhibitor, and a pharmaceutical composition comprising the compounds. The compound is used for treatment, prevention or amelioration of diseases or conditions such as cancer or infection.