公开(公告)号：US11740240B2

公开(公告)日：2023-08-29

申请号：US17379193

申请日：2021-07-19

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： Qian Gao ,  Ravi Kaul ,  Shuxia Zhou ,  Roger P. Walker

IPC: G01N33/569 ,  G01N21/64

CPC classification number: G01N33/56983 ,  G01N21/6428 ,  G01N2021/6439 ,  G01N2333/165

Abstract: The present invention relates to the development of novel immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples. Novel multiplex and singleplex immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples are also provided.