公开(公告)号：US20150110792A1

公开(公告)日：2015-04-23

申请号：US14359784

申请日：2012-11-16

Applicant: Biogen Idec MA Inc. ,  University of Iowa Research Foundation

Inventor： Veronique Bailly ,  Ellen Garber ,  Paul D. Rennert ,  Nicholas Joseph Lennemann ,  Wendy Jean Maury ,  Sven Henrik Moller-Tank

IPC: C07K16/28

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies and antibody fragments that bind to human TIM-1 on the BED face of the protein are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to inhibit or reduce TIM-1 binding to phosphatidylserine, inhibit or reduce TIM-1 binding to dendritic cells, and treat or prevent immunological disorders such as inflammatory and autoimmune conditions.

Abstract translation: 公开了在蛋白质的BED面上结合人TIM-1的抗体和抗体片段。 还公开了使用抗体和抗体片段抑制或降低TIM-1与磷脂酰丝氨酸结合，抑制或降低TIM-1与树突状细胞的结合以及治疗或预防免疫学疾病如炎性和自身免疫病症的方法。

公开(公告)号：US20130101549A1

公开(公告)日：2013-04-25

申请号：US13660238

申请日：2012-10-25

Applicant: BIOGEN IDEC MA INC.

Inventor： Xinzhong Wang ,  Veronique Bailly ,  Graham K. Farrington ,  Alexey Lugovskoy

IPC: C07K16/30 ,  C07K14/525

CPC classification number: C07K16/30 ,  C07K14/525 ,  C07K14/7151 ,  C07K2319/01 ,  G01N33/57415

Abstract: LIGHT-targeting molecules (e.g., LIGHT fusion molecules), compositions, e.g., pharmaceutical compositions thereof, are disclosed. Methods of using these molecules to treat, prevent and/or diagnose hyperproliferative, e.g., neoplastic, diseases or conditions, including, but not limited to, cancer and metastasis are also provided.

Abstract translation: 公开了光靶向分子（例如，LIGHT融合分子），组合物，例如其药物组合物。 还提供了使用这些分子来治疗，预防和/或诊断过度增殖，例如肿瘤性疾病或病症（包括但不限于癌症和转移）的方法。