公开(公告)号：US12195744B2

公开(公告)日：2025-01-14

申请号：US16606567

申请日：2018-04-18

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Laura M. Rogers ,  George J. Weiner ,  Adam J. Dupuy

IPC: C12N15/63 ,  A61K39/00 ,  A61P35/00 ,  C12N5/00 ,  C12N5/0783 ,  C12N15/86 ,  C12N15/90

Abstract: Disclosed are compositions, kits, and methods for identifying genes that are involved in T-cell trafficking. In particular, the compositions, kits, and methods may be used to identify genes involved in T-cell trafficking and/or infiltration into tumors such as genes that encode immune checkpoint regulators and/or stimulatory agents. The disclosed compositions, kits, and methods utilize the Sleeping Beauty® transposon system in a mouse tumor model to identify genes that are involved in T-cell trafficking and infiltration into tumors. The genes identified in the disclosed methods may provide immunotherapy targets in the tumor microenvironment. The identified genes may be utilized in order to develop therapies that enhance T-cell trafficking and infiltration into tumors and/or T-cell killing of tumors such as in chimeric antigen receptor (CAR) T cell therapies.

公开(公告)号：US20250009775A1

公开(公告)日：2025-01-09

申请号：US18886318

申请日：2024-09-16

Applicant: The Board of Trustees of the University of Illinois ,  University of Iowa Research Foundation

Inventor： Martin D. Burke ,  Katrina A. Muraglia ,  Rajeev S. Chorghade ,  Michael J. Welsh

IPC: A61K31/7048 ,  A61K9/00 ,  A61K9/127 ,  A61K31/575 ,  A61P11/00

Abstract: Disclosed are methods of treating cystic fibrosis using AmB and a sterol or compositions comprising AmB and a sterol. Also disclosed are methods of increasing the pH of airway surface liquid in a patient having cystic fibrosis using AmB and a sterol; and methods of decreasing the viscosity of airway surface liquid in a patient having cystic fibrosis using AmB and a sterol.

公开(公告)号：US12156706B2

公开(公告)日：2024-12-03

申请号：US17749988

申请日：2022-05-20

Applicant: University of Iowa Research Foundation

Inventor： Sandeep Laroia

IPC: A61B34/20 ,  A61B17/3211 ,  A61B17/34 ,  A61B34/32

Abstract: A system and method for performing an automated medical procedure is provided. The method may include positioning an effector unit over a patient, acquiring medical imagery of the patient, analyzing the medical imagery using at least one processor to determine a location, and positioning a subunit of the effector unit to perform the automated medical procedure at the location. The automated medical procedure may be performed using at least one of a plurality of subunits of the effector unit. The automated medical procedure may be a body fluid aspiration procedure and one of the plurality of subunits of the effector unit may include a fluid aspirating cannula. Multiple subunits may be sequentially used to perform the procedure.

公开(公告)号：US12138657B2

公开(公告)日：2024-11-12

申请号：US17879385

申请日：2022-08-02

Applicant: University of Iowa Research Foundation

Inventor： Hongtao Ding ,  Avik Samanta ,  Wuji Huang

IPC: B05D7/14 ,  B05D3/06 ,  B05D5/04 ,  B05D5/08 ,  B23K26/352 ,  C09D5/00 ,  C09D7/80

Abstract: The disclosure relates to maskless, laser-assisted methods for making a metal surface comprising at least one of hydrophobic and hydrophilic regions; and at least one of micro- and nanostructured regions.

公开(公告)号：US12138369B2

公开(公告)日：2024-11-12

申请号：US16312680

申请日：2017-06-27

Applicant: University of Iowa Research Foundation

Inventor： Eric Nuxoll ,  Joel Coffel ,  Erica Ricker

IPC: A61L31/14 ,  A61B18/04 ,  A61F2/00 ,  A61F7/00 ,  A61F7/12 ,  A61L2/00 ,  A61L27/34 ,  A61L27/50 ,  A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61N2/00 ,  A61N2/02

Abstract: A system for disrupting a biofilm on a medical device that comprises an implantable medical device; a magnetically-sensitive coating on the surface of the implantable device comprising a polymer and magnetic particles embedded within the polymer; and a coil element capable of generating an alternating magnetic field, wherein the coil element is constructed and arranged to be capable of applying an alternating magnetic field to induce heating of the surface of the implantable device.

公开(公告)号：US20240368498A1

公开(公告)日：2024-11-07

申请号：US18652556

申请日：2024-05-01

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Ned B. Bowden ,  Nimesh Pasan Ranasin Ranasinghe Arachchige

IPC: C11C1/00

Abstract: The invention provides methods that can be used to separate mixtures of fatty acids and fatty acid esters into individual components or into more concentrated mixtures of individual components.

公开(公告)号：US12128115B2

公开(公告)日：2024-10-29

申请号：US17051037

申请日：2019-04-25

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael K. Schultz ,  Christopher Pigge ,  Mengshi Li ,  Moustafa Gabr ,  Edwin Sagastume

IPC: A61K51/04 ,  A61K45/06 ,  A61K51/08

CPC classification number: A61K51/0482 ,  A61K45/06 ,  A61K51/0497 ,  A61K51/083

Abstract: A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(═O)NHRa; each of R5-R12 is independently selected from the group consisting of H and -L-X; each Ra is independently selected from the group consisting of H and -L-X; each L is independently selected from the group consisting of absent and a linking group; and each X is a biological agent; and wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition.

公开(公告)号：US12097050B2

公开(公告)日：2024-09-24

申请号：US17434333

申请日：2020-02-27

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Stephen Baek ,  Yusen He ,  Xiaodong Wu ,  Yusung Kim ,  Bryan G. Allen ,  John Buatti ,  Brian J. Smith

IPC: A61B5/00 ,  G06T7/11

CPC classification number: A61B5/7264 ,  A61B5/7275 ,  G06T7/11 ,  G06T2200/04 ,  G06T2207/10081 ,  G06T2207/10104 ,  G06T2207/20084 ,  G06T2207/30096

Abstract: Methods and systems for image segmentation and analysis are described. A predictive model may be trained to identify and/or extract a rich set of image features with extensive prognostic value. For example, the predictive model may be trained to identify and/or extract features that that may be visualized to identify areas of interest (e.g., high-risk regions, etc.) within or adjacent to an object of interest, such a tumor. The predictive model may be trained to identify and/or extract features that that may predict a health related outcome, such as cancer patient survival/death, and modify therapeutic outcomes, such as diagnosis and treatment.

公开(公告)号：US12090071B2

公开(公告)日：2024-09-17

申请号：US16787291

申请日：2020-02-11

Applicant: The University of Iowa Research Foundation

Inventor： Benjamin Dickerhoff ,  Robert S. Farivar ,  Madhavan L. Raghavan ,  Vijay Kumar

IPC: A61F2/24 ,  A61F2/86 ,  A61F2/95 ,  A61L27/20 ,  A61L27/50 ,  B29C39/02 ,  B29C39/10 ,  C21D1/18 ,  C22F1/10 ,  A61F2/07 ,  B29K1/00

CPC classification number: A61F2/86 ,  A61F2/2415 ,  A61F2/95 ,  A61L27/20 ,  A61L27/507 ,  B29C39/025 ,  B29C39/10 ,  C21D1/18 ,  C22F1/10 ,  A61F2/07 ,  A61F2220/0025 ,  A61F2240/001 ,  B29K2001/00 ,  Y10T29/49826 ,  A61L27/20 ,  C08L1/02

Abstract: Vascular prosthetic assemblies (e.g., heart valves), such as those, for example, configured to be deployed percutaneously.

公开(公告)号：US12083137B2

公开(公告)日：2024-09-10

申请号：US17332324

申请日：2021-05-27

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Sarah Holstein ,  David Wiemer

IPC: A61K31/683 ,  A61K45/06 ,  C07F9/6518

CPC classification number: A61K31/683 ,  A61K45/06 ,  C07F9/6518

Abstract: Disclosed herein are inhibitors of the GGDPS enzyme, and methods for their use in treating or preventing diseases, such as multiple myeloma. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof:




wherein the substituents are described.