利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

2 条记录 (耗时 0.011 秒)

    DENGUE VIRUS-SPECIFIC SIRNA, DOUBLE HELIX OLIGO-RNA STRUCTURE COMPRISING SIRNA, AND COMPOSITION FOR SUPPRESSING PROLIFERATION OF DENGUE VIRUS COMPRISING RNA STRUCTURE
    1.
    发明申请
    DENGUE VIRUS-SPECIFIC SIRNA, DOUBLE HELIX OLIGO-RNA STRUCTURE COMPRISING SIRNA, AND COMPOSITION FOR SUPPRESSING PROLIFERATION OF DENGUE VIRUS COMPRISING RNA STRUCTURE 有权
    登革病毒特异性SIRNA，包含SIRNA的双重HELIX OLIGO-RNA结构和用于抑制包含RNA结构的登革热病毒增殖的组合物

    公开(公告)号：US20160145622A1

    公开(公告)日：2016-05-26

    申请号：US14902564

    申请日：2014-07-04

    申请人： BIONEER CORPORATION

    发明人： Joo Sung Yang ,  Woo Seok Kim ,  Soon Ja Choi ,  Han Oh Park

    IPC分类号： C12N15/113

    CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2310/3521 ,  C12N2310/3525 ,  C12N2310/3533

    摘要： The present invention relates to a dengue virus-specific siRNA, a double-stranded oligo RNA structure comprising the siRNA, and a composition for inhibiting dengue virus replication, which comprises the same, in which the double-stranded oligo RNA structure comprises a hydrophilic compound and hydrophobic compound conjugated to both ends of the double-stranded RNA (siRNA) by a single covalent bond or a linker-mediated covalent bond so that they will be efficiently delivered into cells, and can be converted into nanoparticles by hydrophobic interactions between the double-stranded oligo RNA structures in an aqueous solution. The siRNA included in the double-stranded oligo RNA structure acts specifically on all dengue virus serotypes. The present invention also relates to a method for preparing the double-stranded oligo RNA structure, and a pharmaceutical composition for preventing or treating dengue virus infection, which comprises the double-stranded oligo RNA structure.

    摘要翻译： 本发明涉及登革病毒特异性siRNA，包含siRNA的双链寡聚RNA结构和用于抑制登革病毒复制的组合物，其包含其中双链寡RNA结构包含亲水化合物 和通过单个共价键或连接体介导的共价键与双链RNA（siRNA）的两端缀合的疏水性化合物，使得它们将被有效地递送到细胞中，并且可以通过双重的疏水相互作用转化成纳米颗粒 在水溶液中的品系寡聚RNA结构。 包含在双链寡聚RNA结构中的siRNA特异性地对所有登革热病毒血清型起作用。 本发明还涉及制备双链寡聚RNA结构的方法，以及包含双链寡聚RNA结构的用于预防或治疗登革病毒感染的药物组合物。