公开(公告)号：US20240299437A1

公开(公告)日：2024-09-12

申请号：US18261882

申请日：2022-02-25

申请人： BIONEER CORPORATION ,  SIRNAGEN THERAPEUTICS CORPORATION

发明人： HAN OH PARK ,  SANG KYU LEE ,  OH SEUNG KWON ,  EUN AH GOH

IPC分类号： A61K31/7105 ,  A61K8/60 ,  A61K9/51 ,  A61K31/713 ,  A61K47/54 ,  A61K47/58 ,  A61K47/60 ,  A61K47/69 ,  A61P17/00 ,  A61Q5/00 ,  A61Q7/00 ,  C12N15/113

CPC分类号： A61K31/7105 ,  A61K8/606 ,  A61K9/51 ,  A61K31/713 ,  A61K47/543 ,  A61K47/554 ,  A61K47/58 ,  A61K47/60 ,  A61K47/6929 ,  A61P17/00 ,  A61Q5/00 ,  A61Q7/00 ,  C12N15/113

摘要： The present invention relates to a composition for alleviating hair graying, promoting hair growth and/or preventing or alleviating hair loss, comprising double-stranded miRNA as an active ingredient and, more specifically, to: miR-3139, miR-3189, miR-3199 or miR-8485, which are double-stranded miRNA; a double-stranded oligonucleotide structure comprising same; or a pharmaceutical or cosmetic composition for alleviating hair graying, promoting hair growth and/or preventing or alleviating hair loss, comprising nanoparticles containing the structure as an active ingredient. A composition according to the present invention can prevent hair graying and reduce the rate of progress thereof by activating melanocytes and promoting melanogenesis and can allow the hair already affected by graying to be improved to a state before graying. In addition, the composition promotes the activation of melanocytes and the proliferation of dermal papilla cells and keratinocytes that are present in hair follicles, and induces outer root sheath development and hair growth so that the effects of promoting hair growth and/or preventing hair loss can be exhibited.