公开(公告)号：US20220347308A1

公开(公告)日：2022-11-03

申请号：US17867128

申请日：2022-07-18

Applicant: BIONTECH AG

Inventor： Steve PASCOLO

IPC: A61K47/64 ,  A61P37/04 ,  A61P35/00 ,  A61K39/00 ,  A61K9/51

Abstract: The present invention relates to a method for inducing an immune response manifested by type I interferon production in a synergistic manner comprising the sequential administration of danger signals within a certain timeframe and means for practicing the method. The present invention is particularly useful for immunomodulation, immunotherapy and vaccination.

公开(公告)号：US20180318436A1

公开(公告)日：2018-11-08

申请号：US15763601

申请日：2016-10-20

Applicant: BIONTECH AG

Inventor： Steve PASCOLO

IPC: A61K47/64 ,  A61P37/04 ,  A61K9/51 ,  A61K39/00 ,  A61P35/00

CPC classification number: A61K47/6455 ,  A61K9/513 ,  A61K39/001141 ,  A61K2039/545 ,  A61K2039/55555 ,  A61P35/00 ,  A61P37/04

Abstract: The present invention relates to a method for inducing an immune response manifested by type I interferon production in a synergistic manner comprising the sequential administration of danger signals within a certain timeframe and means for practicing the method. The present invention is particularly useful for immunomodulation, immunotherapy and vaccination.

公开(公告)号：US20210205447A1

公开(公告)日：2021-07-08

申请号：US17209926

申请日：2021-03-23

Applicant: BIONTECH AG

Inventor： Steve PASCOLO

IPC: A61K39/39

Abstract: The present invention relates to particles comprising RNA, in which the RNA is associated with a cationic polymer or lipid or with both a cationic polymer and lipid, wherein the RNA comprises a cytotoxic nucleotide or cytotoxic nucleotide analog and/or the RNA is covalently attached to a cytotoxin, pharmaceutical compositions containing said particles and pharmaceutical uses of the particles and pharmaceutical compositions. The particles of the present invention are particularly useful as an immunostimulating medicament capable to block proliferation or induce death in dividing cells such as tumor cells.

公开(公告)号：US20180289797A1

公开(公告)日：2018-10-11

申请号：US15763541

申请日：2016-10-20

Applicant: BIONTECH AG

Inventor： Steve PASCOLO

IPC: A61K39/39

Abstract: The present invention relates to particles comprising RNA, in which the RNA is associated with a cationic polymer or lipid or with both a cationic polymer and lipid, wherein the RNA comprises a cytotoxic nucleotide or cytotoxic nucleotide analog and/or the RNA is covalently attached to a cytotoxin, pharmaceutical compositions containing said particles and pharmaceutical uses of the particles and pharmaceutical compositions. The particles of the present invention are particularly useful as an immunostimulating medicament capable to block proliferation or induce death in dividing cells such as tumor cells.