公开(公告)号：US12011509B2

公开(公告)日：2024-06-18

申请号：US17509478

申请日：2021-10-25

申请人： Tree of Knowledge International Corp.

发明人： Anshuman Jakhmola ,  Jahangir Tavakkoli ,  Kevin Rod

IPC分类号： A61K9/51 ,  A61K31/05 ,  A61K31/353 ,  B01D21/26

CPC分类号： A61K9/5192 ,  A61K9/5115 ,  A61K9/513 ,  A61K31/05 ,  A61K31/353 ,  B01D21/262

摘要： The present invention relates to development of a novel cannabinoid-based gold nanoparticle drug delivery system for intravenous or localized administration of cannabinoid drugs. More specifically, the gold nanoparticles with a specific size range are conjugated with various cannabinoid molecules (CBD and THC molecules) to synthesize a stable and biocompatible nano-delivery system suitable for both localized and intravenous administration.

公开(公告)号：US20240108586A1

公开(公告)日：2024-04-04

申请号：US18239715

申请日：2023-08-29

申请人： ANP Technologies, Inc. ,  Fulgent Pharma, Inc.

发明人： Ray Yin ,  Jing Pan ,  Yubei Zhang ,  Bingsen Zhou ,  Yun Yen

IPC分类号： A61K9/51 ,  A61K9/00 ,  A61K9/19 ,  A61K31/337

CPC分类号： A61K9/5146 ,  A61K9/0019 ,  A61K9/19 ,  A61K9/513 ,  A61K31/337 ,  B82Y5/00

摘要： Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with a taxane, such as, paclitaxel and derivatives thereof, which are water insoluble or poorly water soluble. The aggregates are formed by interaction of a taxane and a homopolymer. Such aggregates improve drug solubility, stability, delivery and efficacy.

公开(公告)号：US11858884B2

公开(公告)日：2024-01-02

申请号：US17566666

申请日：2021-12-30

申请人： The Board of Regents of The University of Texas System

发明人： Daniel J. Siegwart ,  Kejin Zhou

IPC分类号： C07C321/14 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/59 ,  A61K47/60 ,  A61K47/69 ,  A61K48/00 ,  C07C323/52 ,  C07D295/15 ,  A61K47/20 ,  A61K47/22

CPC分类号： C07C321/14 ,  A61K9/513 ,  A61K9/5146 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6931 ,  A61K48/0041 ,  C07C323/52 ,  C07D295/15

摘要： Disclosed herein are methods for modulating an amount or activity of a gene or a gene product in a cell. The methods herein may comprise contacting a cell with a therapeutic agent assembled with a lipid composition, which lipid composition may comprise a dendrimer or dendron which may comprise one or more degradable diacyl group, in which may result in modulating the amount or activity of the gene or the gene product in the cell. The therapeutic agent modulating a gene or gene product in a cell may be sufficient to treat a disease or disorder in a subject. Further disclosed herein are pharmaceutical compositions, kits, and lipid compositions for modulating an amount or activity of a gene or a gene product in a cell.

公开(公告)号：US20180235897A1

公开(公告)日：2018-08-23

申请号：US15892140

申请日：2018-02-08

申请人： Wisconsin Alumni Research Foundation

发明人： Shaoqin GONG ,  Wei XU ,  Yuyuan WANG ,  Fabao LIU

IPC分类号： A61K9/51 ,  A61K38/00 ,  A61K38/10

CPC分类号： A61K9/5146 ,  A61K9/513 ,  A61K38/005 ,  A61K38/10 ,  A61K47/595 ,  A61K47/60 ,  C07K7/08 ,  C07K17/06

摘要： Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.

公开(公告)号：US20180185508A1

公开(公告)日：2018-07-05

申请号：US15904254

申请日：2018-02-23

申请人： École Polytechnique Fédérale de Lausanne (EPFL)

发明人： Jeffrey A. Hubbell ,  Stephan Kontos ,  Karen Y. Dane

IPC分类号： A61K47/68 ,  C12N9/82 ,  C12N9/96 ,  A61K9/107 ,  A61K9/51 ,  A61K39/00 ,  C07K7/08 ,  C07K14/62 ,  C07K14/74 ,  C07K16/18 ,  C07K16/28 ,  A61K38/00

CPC分类号： A61K47/6811 ,  A61K9/1075 ,  A61K9/513 ,  A61K38/00 ,  A61K39/0008 ,  A61K39/001 ,  A61K47/64 ,  A61K47/6803 ,  A61K47/6815 ,  A61K47/6843 ,  A61K47/6849 ,  A61K2039/6031 ,  A61K2039/605 ,  A61K2039/6056 ,  C07K7/08 ,  C07K14/62 ,  C07K14/70539 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/23 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/41 ,  C07K2319/43 ,  C07K2319/74 ,  C12N9/82 ,  C12N9/96 ,  C12Y305/01001

摘要： Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

公开(公告)号：US20180185507A1

公开(公告)日：2018-07-05

申请号：US15904248

申请日：2018-02-23

申请人： École Polytechnique Fédérale de Lausanne (EPFL)

发明人： Jeffrey A. Hubbell ,  Stephan Kontos ,  Karen Y. Dane

IPC分类号： A61K47/68 ,  C12N9/82 ,  C12N9/96 ,  A61K9/107 ,  A61K9/51 ,  A61K39/00 ,  C07K7/08 ,  C07K14/62 ,  C07K14/74 ,  C07K16/18 ,  C07K16/28 ,  A61K38/00

CPC分类号： A61K47/6811 ,  A61K9/1075 ,  A61K9/513 ,  A61K38/00 ,  A61K39/0008 ,  A61K39/001 ,  A61K47/64 ,  A61K47/6803 ,  A61K47/6815 ,  A61K47/6843 ,  A61K47/6849 ,  A61K2039/6031 ,  A61K2039/605 ,  A61K2039/6056 ,  C07K7/08 ,  C07K14/62 ,  C07K14/70539 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/23 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/41 ,  C07K2319/43 ,  C07K2319/74 ,  C12N9/82 ,  C12N9/96 ,  C12Y305/01001

摘要： Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

公开(公告)号：US20170348264A1

公开(公告)日：2017-12-07

申请号：US15686727

申请日：2017-08-25

申请人： The Board of Regents of the University of Oklahoma

发明人： Sunny Po

IPC分类号： A61K31/197 ,  A61K41/00 ,  A61K33/02 ,  A61K9/51 ,  A61K9/08 ,  A61N2/00 ,  A61K9/00

CPC分类号： A61K31/197 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/5094 ,  A61K9/51 ,  A61K9/5115 ,  A61K9/513 ,  A61K9/5146 ,  A61K9/5153 ,  A61K33/02 ,  A61K33/06 ,  A61K41/00 ,  A61N2/00 ,  B82Y5/00

摘要： Compositions and methods for treating various cardiovascular disorders include targeted delivery of glutamate for impairing a targeted portion of the autonomic nervous system (ANS). Targeted delivery may be via direct injection into the targeted portion of the ANS or via vascular injection of magnetically-targetable nanoparticles.

公开(公告)号：US20170095558A1

公开(公告)日：2017-04-06

申请号：US15269058

申请日：2016-09-19

申请人： UNIVERSITY OF SOUTH CAROLINA

发明人： Peisheng Xu ,  Huacheng He

IPC分类号： A61K41/00 ,  A61K31/704 ,  A61N5/06 ,  A61K9/16

CPC分类号： A61K41/0057 ,  A61K9/0009 ,  A61K9/513 ,  A61K31/704 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6849 ,  A61K47/6935 ,  A61K47/6937 ,  A61N5/062 ,  A61N5/0625 ,  A61N2005/0659

摘要： Described is a biodegradable and biocompatible hybrid nanoparticle for use in photothermal applications. The hybrid nanoparticle includes a poly(lactide-co-glycolic acid) core and a polydopamine shell. Optionally, the hybrid nanoparticle can be loaded with an active agent such as an anti-cancer agent. The hybrid nanoparticles can include detection agents, targeting agents, etc. The nanoparticles can be useful for disease detection, treatment, and monitoring.

公开(公告)号：US20170095448A1

公开(公告)日：2017-04-06

申请号：US15384174

申请日：2016-12-19

申请人： ICEUTICA PTY LTD.

发明人： Aaron Dodd ,  Felix Meiser ,  Marck Norret ,  Adrian Russell ,  H. William Bosch

IPC分类号： A61K31/405 ,  A61K9/51

CPC分类号： A61K31/405 ,  A61J3/02 ,  A61K9/14 ,  A61K9/143 ,  A61K9/145 ,  A61K9/146 ,  A61K9/5115 ,  A61K9/5123 ,  A61K9/513 ,  A61K9/5192 ,  B82Y5/00 ,  Y10S977/915 ,  Y10T428/2982

摘要： The present invention relates to methods for producing particles of indomethacin using dry milling processes as well as compositions comprising indomethacin, medicaments produced using indomethacin in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of indomethacin administered by way of said medicaments.

公开(公告)号：US09517257B2

公开(公告)日：2016-12-13

申请号：US13397202

申请日：2012-02-15

申请人： Jeffrey A. Hubbell ,  Stéphane Kontos ,  Karen Y. Dane

发明人： Jeffrey A. Hubbell ,  Stéphane Kontos ,  Karen Y. Dane

IPC分类号： C07K14/62 ,  C12N9/82 ,  A61K39/00 ,  C07K7/08 ,  C07K16/18 ,  C07K14/74 ,  A61K9/107 ,  A61K9/51 ,  A61K38/00

CPC分类号： A61K47/6811 ,  A61K9/1075 ,  A61K9/513 ,  A61K38/00 ,  A61K39/0008 ,  A61K39/001 ,  A61K47/64 ,  A61K47/6803 ,  A61K47/6815 ,  A61K47/6843 ,  A61K47/6849 ,  A61K2039/6031 ,  A61K2039/605 ,  A61K2039/6056 ,  C07K7/08 ,  C07K14/62 ,  C07K14/70539 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/23 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/41 ,  C07K2319/43 ,  C07K2319/74 ,  C12N9/82 ,  C12N9/96 ,  C12Y305/01001

摘要： Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

摘要翻译： 描述了特异性结合红细胞的肽。 这些作为肽配体提供，其具有与红细胞特异性结合的序列，或作为提供特异性结合的抗体或其片段。 肽可以制备成具有治疗剂，耐受抗原或靶向肽的分子融合物。 可以通过使用融合物和在需要耐受性的物质上选择抗原来产生免疫耐受性。