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公开(公告)号：US20250057944A1
公开(公告)日：2025-02-20
申请号：US18702860
申请日：2022-10-21
Inventor： Jorge Moreno Herrero , Heinrich Haas , Stephanie Erbar , José Manuel García Fernández , Juan Manuel Benito Hernández , Jose Lopez Fernandez
IPC: A61K39/385 , A61K39/00 , A61K39/04 , A61K39/145 , A61P37/04
Abstract: The present disclosure provides complexes comprising a cationic oligosaccharide and an RNA, wherein the cationic oligosaccharide comprises a plurality of cationic moieties bonded to a trehalose, a sucrose, or a gluco-n-oligosaccharide moiety, where n is 2-6, and a ratio of N/P in the complex is less than 20:1
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公开(公告)号：US20240417418A1
公开(公告)日：2024-12-19
申请号：US18702855
申请日：2022-10-21
Inventor： Jorge Moreno Herrero , Heinrich Haas , Stephanie Erbar , José Manuel García Fernández , Juan Manuel Benito Hernández , Jose Lopez Fernandez , Práxedes Sánchez Mellado
IPC: C07H15/04 , A61K9/00 , A61K31/7105 , A61K47/54 , C07H1/00
Abstract: The present disclosure provides compounds, compositions, and complexes useful for delivery of certain agents, including, for example, nucleic acids.
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公开(公告)号：US20250027066A1
公开(公告)日：2025-01-23
申请号：US18708333
申请日：2022-11-09
Applicant: BIONTECH SE
Inventor： Ugur Sahin , Andreas Henning , Stephanie Erbar , Stefan Albrecht Schille , Anna Spier , Lorenzo Corsini , Zehra Visram
Abstract: The invention provides agents and methods for treating bacterial infections using RNA. The RNA encoding peptidoglycan hydrolases. e.g., endolysins, is formulated and administered in a way that peptidoglycan hydrolase proteins. e.g., endolysin proteins, can be produced and secreted by cells of a subject to combat bacterial infections.
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Patent Agency Ranking
公开(公告)号：US20250002522A1
公开(公告)日：2025-01-02
申请号：US18702857
申请日：2022-10-21
Inventor： Jorge Moreno Herrero , Heinrich Haas , Stephanie Erbar , José Manuel García Fernández , Juan Manuel Benito Hernández , Jose Lopez Fernandez , Práxedes Sánchez Mellado
Abstract: The present disclosure provides compositions comprising an oligosaccharide of formula (I), wherein said compositions are useful for delivery of certain agents, including, for example, nucleic acids.
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公开(公告)号：US12150947B2
公开(公告)日：2024-11-26
申请号：US16957898
申请日：2019-01-10
Applicant: BioNTech SE , TRON—TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ GGMBH
Inventor： Ugur Sahin , Heinrich Haas , Annette Vogel , Stephanie Erbar , Kerstin Walzer , Anne Schlegel , Sebastian Hörner , Jorge Herrero Moreno , Thorsten Klamp , Sebastian Kreiter , Mustafa Diken , Phillip Heller
IPC: A61K31/70 , A61K9/00 , A61K35/763 , A61K47/18
Abstract: The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine.
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公开(公告)号：US20250057960A1
公开(公告)日：2025-02-20
申请号：US18702858
申请日：2022-10-21
Applicant: BioNTech SE , Consejo Superior de Investigaciones Científicas (CSIC) , Universidad de Sevilla
Inventor： Jorge Moreno Herrero , Heinrich Haas , Stephanie Erbar , Theo Benjamin Stahl , José Manuel García Fernández , Juan Manuel Benito Hernández , Jose Lopez Fernandez , Maria del Carmen Ortiz Mellet , Noelia de la Cruz Ruiz , Manuel González Cuesta , Egon Jack Jacobus Ambuludi , Irena Vlatkovic
IPC: A61K47/54 , A61K9/00 , A61K31/713 , A61P31/16 , C12N15/88
Abstract: The present disclosure provides complexes comprising: i) a cationic oligosaccharide comprising one or more cationic moieties bonded to a trehalose, a sucrose, or a gluco-n-oligosaccharide moiety, where n is 2-6; ii) a surfactant; and iii) one or more additives selected from: a sterol, a helper lipid, an immunomodulator, and a targeting molecule; and uses thereof.
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公开(公告)号：US20240425541A1
公开(公告)日：2024-12-26
申请号：US18702863
申请日：2022-10-21
Inventor： Jorge Moreno Herrero , Heinrich Haas , Stephanie Erbar , José Manuel García Fernández , Maria del Carmen Ortiz Mellet , Juan Manuel Benito Hernández , Jose Lopez Fernandez , Jose Luis Jimenez Blanco
Abstract: The present disclosure provides a compound of formula I, as well as complexes and compositions comprising a compound of formula I, wherein said compositions and complexes are useful for delivery of certain agents, including, for example, nucleic acids.
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公开(公告)号：US20220313811A1
公开(公告)日：2022-10-06
申请号：US17717645
申请日：2022-04-11
Applicant: BIONTECH SE , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ
Inventor： Ugur Sahin , Heinrich Haas , Annette Vogel , Daniel Zucker , Stephanie Erbar , Kerstin Walzer , Anne Schlegel , Sebastian Hörner , Sebastian Kreiter , Mustafa Diken , Jorge Moreno Herrero
Abstract: The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.
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