公开(公告)号：US20230089459A1

公开(公告)日：2023-03-23

申请号：US17788534

申请日：2020-12-22

申请人： BIOPHYTIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  NSERM (INSTITUT NATIONAL DE LA SANTE ET DELA RECHERCHE ME'DICALE) ,  BORBONNE UNIVERSITE

发明人： Laurence DINAN ,  René LAFONT ,  Pierre DILDA ,  Serge CAMELO ,  Valérie FONTAINE ,  Christine BALDUCCI ,  Elodie MONTEIRO ,  Louis GUIBOUT ,  Mathilde LATIL ,  José-Alain SAHEL ,  Stanislas VEILLET

IPC分类号： C07C211/21 ,  C07D265/30 ,  C07D211/32 ,  C07D273/06 ,  C07D207/06 ,  C07D307/36 ,  A61P27/02

摘要： Disclosed is chemical compounds C that are derivatives of norbixin and have tropism for the eye, and are intended to be used in the treatment of eye diseases in mammals, in particular in the context of altering the retinal pigment epithelium and more particularly in the context of age-related macular degeneration (AMD) and Stargardt's disease.

公开(公告)号：US20170086453A1

公开(公告)日：2017-03-30

申请号：US15290825

申请日：2016-10-11

申请人： INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

发明人： Fabrice CHRETIEN ,  Mathilde LATIL ,  Shahragim TAJBAKHSH

IPC分类号： A01N1/02 ,  A61K35/14 ,  C12N5/077 ,  A61K35/34 ,  C12N5/0797 ,  C12N5/0789

CPC分类号： A01N1/0284 ,  A01N1/021 ,  A61K35/14 ,  A61K35/28 ,  A61K35/34 ,  A61K2035/124 ,  C12N5/0623 ,  C12N5/0647 ,  C12N5/0659 ,  C12N5/0668 ,  C12N2500/02

摘要： The present invention relates to methods for obtaining stem cells from mammalian cadavers, methods for obtaining or purifying stem cells from a sample likely to contain non-stem cells, methods of regeneration of injured tissues and methods of treatment.

公开(公告)号：US20200179407A1

公开(公告)日：2020-06-11

申请号：US16609205

申请日：2018-04-27

申请人： BIOPHYTIS ,  SORBONNE UNIVERSITE

发明人： Pierre DILDA ,  René LAFONT ,  Mathilde LATIL ,  Maria SEROVA ,  Onnik AGBULUT ,  Stanislas VEILLET

IPC分类号： A61K31/575

摘要： The invention relates to 20-hydroxyecdysone and the derivatives thereof, for use in the treatment of genetic myopathies.

公开(公告)号：US20230158046A1

公开(公告)日：2023-05-25

申请号：US18158859

申请日：2023-01-24

申请人： BIOPHYTIS ,  SORBONNE UNIVERSITE

发明人： Pierre DILDA ,  Mathilde LATIL ,  René LAFONT ,  Stanislas VEILLET

IPC分类号： A61K31/575 ,  A61P21/06 ,  A61K9/00 ,  A61K31/57

CPC分类号： A61K31/575 ,  A61P21/06 ,  A61K9/0053 ,  A61K31/57

摘要： A composition including at least one phytoecdysone or at least one semi-synthetic derivative of a phytoecdysone, for use in mammals for preventing the loss of muscle strength during immobilisation. More particularly, a composition for use that includes 20-hydroxyecdysone or a semi-synthetic derivative of 20-hydroxyecdysone. Moreover, the composition for use includes a compound of general formula (I).

公开(公告)号：US20230128105A1

公开(公告)日：2023-04-27

申请号：US17915865

申请日：2021-03-24

申请人： BIOPHYTIS ,  SORBONNE UNIVERSITE

发明人： Pierre DILDA ,  René LAFONT ,  Stanislas VEILLET ,  Samuel AGUS ,  Waly DIOH ,  Serge CAMELO ,  Mathilde LATIL ,  Mounia CHABANE DE SAINT AUBIN ,  Cendrine TOURETTE

IPC分类号： A61K31/575 ,  A61P11/00 ,  A61P31/14

摘要： Disclosed are phytoecdysones and semisynthetic derivatives of phytoecdysones, intended to be used in treating impairment of the respiratory function in mammals, in particular in the context of a viral infection and more particularly during an infection by a coronavirus.

公开(公告)号：US20220160732A1

公开(公告)日：2022-05-26

申请号：US17439681

申请日：2020-03-12

申请人： BIOPHYTIS ,  SORBONNE UNIVERSITE

发明人： Mathilde LATIL ,  Pierre DILDA ,  René LAFONT ,  Stanislas VEILLET

IPC分类号： A61K31/575 ,  A61P21/00 ,  A61K31/58

摘要： Disclosed are 20-hydroxyecdysone and the derivatives thereof, intended for use in the treatment of a neuromuscular disease such as spinal muscular atrophy or amyotrophic lateral sclerosis, or more particularly in the treatment of a specific disorder of the motor neurons causing alterations in the muscular function occurring in the context of these neuromuscular diseases.

公开(公告)号：US20220152060A1

公开(公告)日：2022-05-19

申请号：US17439669

申请日：2020-03-12

申请人： BIOPHYTIS ,  SORBONNE UNIVERSITE

发明人： Mathilde LATIL ,  Pierre DILDA ,  René LAFONT ,  Stanislas VEILLET

IPC分类号： A61K31/58 ,  A61P11/00 ,  A61K31/575

摘要： Disclosed are phytoecdysones and the derivatives thereof, intended for use in the treatment of impaired lung function in mammals, in particular in the context of a neuromuscular disease and more particularly when the impaired lung function is linked to a deterioration of the mechanical properties of the lung tissue.

公开(公告)号：US20210369735A1

公开(公告)日：2021-12-02

申请号：US16976189

申请日：2019-02-20

申请人： BIOPHYTIS ,  SORBONNE UNIVERSITE

发明人： Pierre DILDA ,  Mathilde LATIL ,  René LAFONT ,  Stanislas VEILLET

IPC分类号： A61K31/575 ,  A61K31/57 ,  A61K9/00 ,  A61P21/06

摘要： A composition including at least one phytoecdysone or at least one semi-synthetic derivative of a phytoecdysone, for use in mammals for preventing the loss of muscle strength during immobilisation. More particularly, a composition for use that includes 20-hydroxyecdysone or a semi-synthetic derivative of 20-hydroxyecdysone. Moreover, the composition for use includes a compound of general formula (I).