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公开(公告)号：US20240207075A1
公开(公告)日：2024-06-27
申请号：US17802448
申请日：2020-05-27
Applicant: BIOTYX MEDICAL (SHENZHEN) CO., LTD.
Inventor： Dong Bian , Wenjiao Lin
CPC classification number: A61F2/82 , A61L31/022 , A61L31/088 , A61L31/10 , A61L31/16 , A61F2250/0031 , A61F2250/0036 , A61F2250/0054 , A61F2250/0067
Abstract: Disclosed is an absorbable iron-based instrument (10). The absorbable iron-based instrument includes an iron-based matrix (100), a zinc-containing protective layer (200), a corrosion-promoting layer (300) and a drug controlled-release layer (400); the iron-based matrix (100) is provided with an outer wall (110), an inner wall (120) and a side wall (130); the zinc-containing protective layer (200) covers at least the outer wall (110) and the inner wall (120) of the iron-based matrix (100); the corrosion-promoting layer (300) fully covers the zinc-containing protective layer (200); the drug controlled-release layer (400) partially covers at least the corrosion-promoting layer (300); the corrosion-promoting layer (300) and the drug controlled-release layer (400) each contain degradable polymers; the weight-average molecular weight of the degradable polymers in the corrosion-promoting layer (300) is greater than the weight-average molecular weight of the degradable polymers in the drug controlled-release layer (400); and the thickness ratio of a portion of the zinc-containing protective layer (200) that is located at the inner wall (120) to a portion of the corrosion-promoting layer (300) that is located at the inner wall (120) is greater than the thickness ratio of a portion of the zinc-containing protective layer (200) that is located at the outer wall (110) to a portion of the corrosion-promoting layer (300) that is located at the outer wall (110). The corrosion behavior of the absorbable iron-based instrument (10) meets the requirements of clinical use, and the occurrence of adverse histological reactions is rare or avoided.
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