公开(公告)号：US20200085929A1

公开(公告)日：2020-03-19

申请号：US16543980

申请日：2019-08-19

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Laurence JN COOPER ,  Hiroki TORIKAI ,  Ling ZHANG ,  Helen HULS ,  Feng WANG-JOHANNING ,  Lenka HURTON ,  Simon OLIVARES ,  Janani KRISHNAMURTHY

IPC分类号： A61K39/00 ,  A61P37/00 ,  C07K14/725 ,  A61K35/17 ,  C07K14/54 ,  C07K14/705 ,  C07K16/30

摘要： The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

公开(公告)号：US20240156929A1

公开(公告)日：2024-05-16

申请号：US18465547

申请日：2023-09-12

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Laurence J.N. COOPER ,  Hiroki TORIKAI ,  Ling ZHANG ,  Helen HULS ,  Feng WANG-JOHANNING ,  Lenka HURTON ,  Simon OLIVARES ,  Janani KRISHNAMURTHY

IPC分类号： A61K39/00 ,  A61K35/17 ,  A61P37/00 ,  C07K14/54 ,  C07K14/705 ,  C07K14/725 ,  C07K16/30

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K39/001104 ,  A61K39/001106 ,  A61K39/001109 ,  A61K39/00111 ,  A61K39/001112 ,  A61K39/001113 ,  A61K39/001119 ,  A61K39/001124 ,  A61K39/001129 ,  A61K39/001151 ,  A61K39/001164 ,  A61K39/001168 ,  A61K39/00117 ,  A61K39/001171 ,  A61K39/001174 ,  A61K39/001181 ,  A61K39/001182 ,  A61K39/00119 ,  A61K39/001194 ,  A61P37/00 ,  C07K14/5443 ,  C07K14/7051 ,  C07K14/70521 ,  C07K16/30 ,  A61K2039/505 ,  A61K2039/5158 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  Y02A50/30

摘要： The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

公开(公告)号：US20160158285A1

公开(公告)日：2016-06-09

申请号：US14890977

申请日：2014-05-14

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Laurence JN COOPER ,  Hiroki TORIKAI ,  Ling ZHANG ,  Helen HULS ,  Feng WANG-JOHANNING ,  Lenka HURTON ,  Simon OLIVARES ,  Janani KRISHNAMURTHY

IPC分类号： A61K35/17 ,  C07K14/54

CPC分类号： A61K35/17 ,  C07K14/5443 ,  C07K14/7051 ,  Y02A50/411 ,  Y02A50/467

摘要： The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

摘要翻译： 本发明涉及使用包含嵌合抗原受体（CAR）的修饰T细胞的免疫治疗方法和组合物。 在特定方面，CAR表达的T细胞使用电穿孔与基于转座子的整合系统一起产生，以产生需要最小离体扩增或可直接施用于患者疾病的CAR表达细胞群体（例如 ，癌症）治疗。

公开(公告)号：US20220062396A1

公开(公告)日：2022-03-03

申请号：US17223597

申请日：2021-04-06

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Laurence JN COOPER ,  Hiroki TORIKAI ,  Ling ZHANG ,  Helen HULS ,  Feng WANG-JOHANNING ,  Lenka HURTON ,  Simon OLIVARES ,  Janani KRISHNAMURTHY

IPC分类号： A61K39/00 ,  C07K14/725 ,  A61P37/00 ,  A61K35/17 ,  C07K14/54 ,  C07K14/705 ,  C07K16/30

摘要： The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

公开(公告)号：US20170224798A1

公开(公告)日：2017-08-10

申请号：US15434595

申请日：2017-02-16

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Laurence JN COOPER ,  Hiroki TORIKAI ,  Ling ZHANG ,  Helen HULS ,  Feng WANG-JOHANNING ,  Lenka HURTON ,  Simon OLIVARES ,  Janani KRISHNAMURTHY

IPC分类号： A61K39/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/30

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K2039/505 ,  A61K2039/5158 ,  A61P37/00 ,  C07K14/5443 ,  C07K14/7051 ,  C07K14/70521 ,  C07K16/30 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  Y02A50/411 ,  Y02A50/467

摘要： The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.