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公开(公告)号：US20160250230A1
公开(公告)日：2016-09-01
申请号：US15154083
申请日：2016-05-13
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61J3/10 , A61K47/32 , A61K31/496 , A61K31/343 , A61J3/07 , A61K47/38
CPC分类号： A61K31/573 , A61J3/00 , A61J3/07 , A61J3/10 , A61K9/146 , A61K9/1694 , A61K9/2077 , A61K31/343 , A61K31/496 , A61K47/32 , A61K47/38
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
摘要翻译： 用于制备药物剂型的组合物和方法包括制备药物组合物，其包含一种或多种活性药物成分（API）与一种或多种药学上可接受的赋形剂，通过热动力学复合制成复合材料。 将包含一种或多种API的复合材料与一种或多种赋形剂预处理的组合物和方法包括热动力学复合，其包括将所述API与所述赋形剂的热机械加工成复合材料，其中所述复合材料可以通过本领域已知的常规方法进一步加工， 热熔挤出，熔融造粒，压缩成型，片剂压缩，胶囊填充，薄膜包衣或注塑成型。
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公开(公告)号：US20200261473A1
公开(公告)日：2020-08-20
申请号：US16866676
申请日：2020-05-05
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61K47/38 , A61K47/32 , A61K31/496 , A61K31/343 , A61J3/10 , A61J3/07 , A61J3/00 , A61K9/20 , A61K9/16 , A61K9/14
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can he further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
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公开(公告)号：US20180360850A1
公开(公告)日：2018-12-20
申请号：US16012025
申请日：2018-06-19
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61K9/16 , A61K9/20 , A61K9/14 , A61J3/10 , A61K47/32 , A61K31/496 , A61K31/343 , A61J3/00 , A61K47/38 , A61J3/07
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
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公开(公告)号：US20230172949A1
公开(公告)日：2023-06-08
申请号：US17814567
申请日：2022-07-25
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61K9/14 , A61K9/16 , A61K9/20 , A61J3/00 , A61J3/07 , A61J3/10 , A61K31/343 , A61K31/496 , A61K47/32 , A61K47/38
CPC分类号： A61K31/573 , A61K9/146 , A61K9/1694 , A61K9/2077 , A61J3/00 , A61J3/07 , A61J3/10 , A61K31/343 , A61K31/496 , A61K47/32 , A61K47/38
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
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